Lisinopril is a common blood pressure medication that clashes with alcohol. Check out our latest blog for more info on the indirect interactions between the two.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually, with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!
Adding a daily 30-minute walk, swapping out your morning donut for some heart-healthy egg bites, and myriad other tactics to lower your blood pressure just may not do the trick. After another check-up, your may prescribe lisinopril to manage your blood pressure. Now you’re wondering if the occasional glass of wine or bottle of beer fits into the equation.
Mixing medications with alcohol can be like playing with fire. Although the lisinopril label doesn’t clearly state alcohol as a drug interaction, drinking isn’t advised. Drinking while taking lisinopril can open the floodgates to many adverse effects. Let’s explore how alcohol and lisinopril interact to understand why rethinking the drink may be the best move for our health.
Lisinopril is one of the most commonly prescribed FDA-approved medications used to treat high blood pressure. However, it’s also used for many other purposes, including improving symptoms of heart failure, increasing survival rate after a heart attack, and lowering the risk of diabetes. It comes in tablet or solution form and is commonly sold under the brand name Zestril and Prinivil.
The drug is classified as an angiotensin-converting enzyme (ACE) inhibitor. It works by reducing chemicals that tighten our blood vessels. This allows for greater blood flow and, as a result, helps our heart pump more efficiently. Lisinopril is a common medication that can be effective in treating different health concerns, but how safe is it?
Lisinopril is regarded as generally safe, which is why it’s prescribed so frequently. No major adverse effects are associated with it. Although
withdrawal symptoms have been associated with some blood pressure medications but none have been reported with lisinopril. It may cause some mild side effects:
More severe side effects include:
Anyone experiencing any serious side effects after taking lisinopril should immediately stop taking the medication and dial 9-1-1 for emergency medical treatment. Although lisinopril is generally safe, it’s not appropriate for everyone. FDA warnings note that lisinopril shouldn’t be taken by
Lisinopril may be a safe and effective medication, but what about when it’s mixed with alcohol?
Drinking alcohol while taking lisinopril is not recommended. Although no direct interaction with alcohol is listed, mixing the two can cause serious adverse effects.
Alcohol indirectly affects lisinopril in many different ways. When we drink, alcohol can acutely lower our blood pressure — adding to the effects of the medication and increasing the risk of dangerously low blood pressure (hypotension). Over time, alcohol increases our blood pressure, which counteracts the purpose of the medication. This can lead to the ineffectiveness of the medication and other health conditions caused by high blood pressure.
Lisinopril is also used to improve other health issues such as heart failure, recurrence of heart attacks, and risk of diabetes. Drinking has negative impacts on these conditions. Alcohol can trigger atrial fibrillation, or irregular heart rhythm, which increases the risk of heart failure and heart attack. Drinking is also linked to an increased risk of diabetes and kidney damage — counteracting the medication when used for these purposes.
As we can see, although alcohol and lisinopril don’t have any direct interactions, their indirect interactions can be equally as harmful to our health. Lisinopril and alcohol aren’t a good mix, but what about other blood pressure medications?
Drinking while taking any blood pressure medication is not recommended. There are different types of blood pressure medications, including beta blockers, nondihydropyridine calcium channel blockers, angiotensin II blockers (ARBs), and many more that can cause negative effects when mixed with alcohol.
Beta-blockers, a common category of blood pressure medications, work by slowing down our heart rate. When mixed with alcohol, they can cause dangerous side effects such as tachycardia, excess drowsiness, and hypotension. Alcohol also directly interacts with nondihydropyridine calcium channel blockers such as Calan and Cartizem. This can lead to delayed alcohol metabolization — increasing the risk of alcohol poisoning. Other blood pressure medications, such as ARBs and Losartan, don’t interact directly with alcohol, but the combo can lead to increased side effects.
Drinking while taking some blood pressure medications may be more dangerous than others, but should generally be avoided to reduce complications and negative effects. Let’s get a better idea of what these are.
Alcohol can interact differently with different types of blood pressure medications. However, mixing them can lead to general adverse effects from indirect interactions, regardless of the type of blood pressure medication.
Drinking while taking blood pressure medications increases the risk of side effects, but does the amount of alcohol make a difference?
When taking lisinopril, no amount of alcohol is recommended. Although lisinopril interactions with alcohol aren’t direct, indirect interactions can still cause dangerous effects. According to the World Health Organization, no amount of alcohol is safe for our health.
If we do choose to drink, it’s best to consult with our physician, as they have a better idea of our health needs. Being honest with our healthcare provider helps us identify any interactions and helps us adjust our care as needed. Let’s explore some ways to increase our safety when taking lisinopril, drinking, and navigating the two.
If we’ve been prescribed lisinopril, we may feel overwhelmed with all this information. To ensure our health and safety, we can implement mindful consumption strategies:
The only way to eliminate negative effects from mixing alcohol and lisinopril is by avoiding alcohol, but we can reduce the risks using these mindful consumption strategies.
While we often attribute our high blood pressure to certain family members and stressful situations, hypertension can be caused by an interplay of many factors — making management a delicate dance of lifestyle changes and medication. If we’re taking lisinopril for blood pressure or its other uses, drinking alcohol isn’t a good idea. Although there aren’t any direct interactions, alcohol negatively affects our blood pressure and risk of heart issues, which lisinopril is used to treat. By choosing to limit or avoid alcohol, we can manage our hypertension better and take steps towards overall wellness. Cheers to a happy heart!
Adding a daily 30-minute walk, swapping out your morning donut for some heart-healthy egg bites, and myriad other tactics to lower your blood pressure just may not do the trick. After another check-up, your may prescribe lisinopril to manage your blood pressure. Now you’re wondering if the occasional glass of wine or bottle of beer fits into the equation.
Mixing medications with alcohol can be like playing with fire. Although the lisinopril label doesn’t clearly state alcohol as a drug interaction, drinking isn’t advised. Drinking while taking lisinopril can open the floodgates to many adverse effects. Let’s explore how alcohol and lisinopril interact to understand why rethinking the drink may be the best move for our health.
Lisinopril is one of the most commonly prescribed FDA-approved medications used to treat high blood pressure. However, it’s also used for many other purposes, including improving symptoms of heart failure, increasing survival rate after a heart attack, and lowering the risk of diabetes. It comes in tablet or solution form and is commonly sold under the brand name Zestril and Prinivil.
The drug is classified as an angiotensin-converting enzyme (ACE) inhibitor. It works by reducing chemicals that tighten our blood vessels. This allows for greater blood flow and, as a result, helps our heart pump more efficiently. Lisinopril is a common medication that can be effective in treating different health concerns, but how safe is it?
Lisinopril is regarded as generally safe, which is why it’s prescribed so frequently. No major adverse effects are associated with it. Although
withdrawal symptoms have been associated with some blood pressure medications but none have been reported with lisinopril. It may cause some mild side effects:
More severe side effects include:
Anyone experiencing any serious side effects after taking lisinopril should immediately stop taking the medication and dial 9-1-1 for emergency medical treatment. Although lisinopril is generally safe, it’s not appropriate for everyone. FDA warnings note that lisinopril shouldn’t be taken by
Lisinopril may be a safe and effective medication, but what about when it’s mixed with alcohol?
Drinking alcohol while taking lisinopril is not recommended. Although no direct interaction with alcohol is listed, mixing the two can cause serious adverse effects.
Alcohol indirectly affects lisinopril in many different ways. When we drink, alcohol can acutely lower our blood pressure — adding to the effects of the medication and increasing the risk of dangerously low blood pressure (hypotension). Over time, alcohol increases our blood pressure, which counteracts the purpose of the medication. This can lead to the ineffectiveness of the medication and other health conditions caused by high blood pressure.
Lisinopril is also used to improve other health issues such as heart failure, recurrence of heart attacks, and risk of diabetes. Drinking has negative impacts on these conditions. Alcohol can trigger atrial fibrillation, or irregular heart rhythm, which increases the risk of heart failure and heart attack. Drinking is also linked to an increased risk of diabetes and kidney damage — counteracting the medication when used for these purposes.
As we can see, although alcohol and lisinopril don’t have any direct interactions, their indirect interactions can be equally as harmful to our health. Lisinopril and alcohol aren’t a good mix, but what about other blood pressure medications?
Drinking while taking any blood pressure medication is not recommended. There are different types of blood pressure medications, including beta blockers, nondihydropyridine calcium channel blockers, angiotensin II blockers (ARBs), and many more that can cause negative effects when mixed with alcohol.
Beta-blockers, a common category of blood pressure medications, work by slowing down our heart rate. When mixed with alcohol, they can cause dangerous side effects such as tachycardia, excess drowsiness, and hypotension. Alcohol also directly interacts with nondihydropyridine calcium channel blockers such as Calan and Cartizem. This can lead to delayed alcohol metabolization — increasing the risk of alcohol poisoning. Other blood pressure medications, such as ARBs and Losartan, don’t interact directly with alcohol, but the combo can lead to increased side effects.
Drinking while taking some blood pressure medications may be more dangerous than others, but should generally be avoided to reduce complications and negative effects. Let’s get a better idea of what these are.
Alcohol can interact differently with different types of blood pressure medications. However, mixing them can lead to general adverse effects from indirect interactions, regardless of the type of blood pressure medication.
Drinking while taking blood pressure medications increases the risk of side effects, but does the amount of alcohol make a difference?
When taking lisinopril, no amount of alcohol is recommended. Although lisinopril interactions with alcohol aren’t direct, indirect interactions can still cause dangerous effects. According to the World Health Organization, no amount of alcohol is safe for our health.
If we do choose to drink, it’s best to consult with our physician, as they have a better idea of our health needs. Being honest with our healthcare provider helps us identify any interactions and helps us adjust our care as needed. Let’s explore some ways to increase our safety when taking lisinopril, drinking, and navigating the two.
If we’ve been prescribed lisinopril, we may feel overwhelmed with all this information. To ensure our health and safety, we can implement mindful consumption strategies:
The only way to eliminate negative effects from mixing alcohol and lisinopril is by avoiding alcohol, but we can reduce the risks using these mindful consumption strategies.
While we often attribute our high blood pressure to certain family members and stressful situations, hypertension can be caused by an interplay of many factors — making management a delicate dance of lifestyle changes and medication. If we’re taking lisinopril for blood pressure or its other uses, drinking alcohol isn’t a good idea. Although there aren’t any direct interactions, alcohol negatively affects our blood pressure and risk of heart issues, which lisinopril is used to treat. By choosing to limit or avoid alcohol, we can manage our hypertension better and take steps towards overall wellness. Cheers to a happy heart!
Wondering if Xanax and alcohol interactions could be dangerous? Learn why alcohol and Xanax don’t mix in our latest blog. Stay safe while getting relief for anxiety!
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
Panic attacks can be debilitating, like a wave that swallows us whole as we try to find our bearings — and “words of encouragement” tend to make things even worse. As Elyn Saks writes in The Center Cannot Hold: My Journey Through Madness, “In my experience, the words “now just calm down” almost inevitably have the opposite effect on the person you are speaking to.”
While there are many ways to relieve anxiety (more on that later!), for many of us, medications such as Xanax can serve as lifelines. But what about interactions of Xanax and alcohol? In particular, you might be wondering, “If I take Xanax in the morning, can I drink alcohol at night?” The short answer is — not really. It’s best not to risk it. But what are the dangers, exactly? Let’s find out!
Anxiety — when it reaches the level of panic attacks and impacts our daily lives — can be debilitating. It can cause problems at work (especially if our job involves presentations in front of large groups of people, meetings with clients, and even regular huddles with coworkers). It can put a strain on relationships, making us hesitant to accept invitations to weddings or weekend outings. It can steal valuable hours of sleep at night as we toss and turn, unable to get our mind to settle no matter how many sheep we count in our head.
And yet, anxiety is extremely common. In fact, according to the National Institute of Mental Health, over 19% of U.S. adults struggle with it! That’s almost one in five people at that board meeting or at least a couple of members of the wedding party — or a total of about 40 million people around the country. As physician Will Cronenwett tells TODAY.com:
“We live in an unsettled time … There’s inflation. The war. Stuff in the news. And we’re still dealing with COVID and what that did to our baseline anxiety levels … People feel less safe, and feeling unsafe about yourself in the world is similar to the feeling of anxiety disorder.”
For many, medication becomes a lifeline, and benzodiazepines such as lorazepam (Ativan), clonazepam (Klonopin), diazepam (Valium), and alprazolam (Xanax) have historically been some of the most popular. That said, they have their drawbacks — in particular, their sedating side effects and potential for addiction, which we’ll get into a bit later.
Like its benzodiazepine cousins, alprazolam (better known by its brand name Xanax) is frequently prescribed for panic attacks and anxiety disorders. Patented in 1971, Xanax was invented by Jackson Hester Jr. and has been on the medical scene in the U.S. since 1981. In 2021, it ranked 42nd on the “most commonly prescribed medication” list, with more than 15 million prescriptions doled out to (presumably) anxiety sufferers around the country.
Benzodiazepines (affectionately known as “benzos”) work by enhancing the effects of GABA — an inhibitory neurotransmitter in the brain. If this rings a bell, there’s a good reason — alcohol works through a similar mechanism by enhancing GABA and decreasing glutamate, its excitatory counterpart.
As far as benzos are concerned, Xanax is a bit of a “bad boy.” It has stronger effects on some and acts within minutes, with effects lasting between four to six hours. Because it’s more fast-acting than its counterparts, it has more potential for addiction, as well as a heavier presence “on the street.” As Cronenwett explains, “It tends to act quickly and wear off fairly quickly. Often people feel they need to use it more and more frequently. And then the thought of living without it becomes frightening. In some cases, it can begin to look like addiction.” It can also cause severe withdrawal symptoms, such as seizures, especially in those taking a large dose.
There are many slang terms for Xanax in popular culture. Top of the list? “Xannies,” or “Zannies.” Additionally, Xanax is sometimes referred to as “bars,” “ladders,” “footballs,” “planks,” “poles,” “sticks,” “blues,” or “blue footballs.” (All describing the physical shape of the pills, if you haven’t guessed it already.)
A 2022 documentary, Take Your Pills: Xanax, looks deep into the “soul” of this somewhat controversial medicine, describing it as “a cure for some and a curse for others.” Regardless of the path we take when it comes to Xanax alone, however, there’s definite trouble on the horizon when it comes to Xanax and alcohol interactions.
Can you drink on Xanax? Most people know better than to chase a pill with a shot of tequila. But what if we take it in the morning — does it make that margarita or round of beers after work off limits? The truth is, we’re better off staying away from booze for at least 24 hours after taking Xanax. Let’s dive into the reasons why mixing alcohol and Xanax could mean trouble, even with a time gap in between.
Both Xanax and alcohol are depressants that slow down the central nervous system. When we take them together, the depressant effects get amplified and could put us in danger. Here’s why:
In short, mixing two depressants isn’t worth the risk. But that’s not the end of the story!
In addition to excessive sedation, there are other side effects of Xanax that could linger for hours after our dose. Many of them don’t mix with alcohol, so drinking on the same night could be a recipe for trouble.
As we can see, the side effects of Xanax and alcohol together aren’t worth the risk. We’re better off avoiding the combo, and waiting until evening to drink doesn’t necessarily mean we’re in the clear.
When it comes to treating anxiety, Xanax and alcohol are not on the same team (even though they might initially appear to be). While it’s common to think of alcohol as “relaxing,” any relief we feel is the depressant effect at play. However, as the brain attempts to rebalance itself after being flooded with the reward neurotransmitter dopamine and GABA, it releases dynorphin — a neurochemical that is part of our brain's natural way of dampening down the feel-good response. It's like putting on the brakes when things are getting too rowdy. The result? We end up feeling more anxious than we did before.
That flood of dopamine we’ve mentioned a few times? Research shows that Xanax in particular triggers a hefty dose of dopamine to be released in the striatum (part of the reward center of the brain). While all benzodiazepines do so to some degree, alprazolam stands out among the rest. As a result, combining the two substances leads to a more intense dopamine flood — and more potential for dependence, as our brain starts to expect it as the “new normal.”
In fact, Xanax alone should be treated with caution, as far as dependence is concerned. According to NIDA, overdoses on benzos skyrocketed in the last couple of decades, rising from 1,135 in 1999 to 11,537 in 2017. After a brief decline to 9,711 deaths in 2019, overdoses were on the rise again, climbing to 12,499 by 2021. And with more potential for dependence than its chemical cousins, Xanax in particular is responsible for a large chunk of those numbers.
The combination of Xanax and alcohol also increases our chances of having an overdose. With alcohol in our system, the concentration of Xanax in our bloodstream gets higher. As a result, effects (such as sedation) get more pronounced.
Remember how we said it’s best to wait at least 24 hours after taking Xanax before having a drink? That’s because it typically takes about 11.2 hours for half of our Xanax dose to metabolize and leave our body. And given that we’re better off waiting until most of it has left our system, a full day is the way to go.
That said, there are many additional factors at play when it comes to determining the exact timing of when it might be safe to drink after taking Xanax.
All in all, mixing benzos and alcohol is risky business. Most doctors advise against drinking on any benzodiazepines, as the combo can be unpredictable, potentially causing severe side effects and complications.
Finally, here are some tips for reducing anxiety while staying safe when it comes to the Xanax and alcohol combo.
With these tips, you’ll be able to manage your anxiety better. You might find that you’re not even craving that drink at night after all! And remember, Reframe is always here to help if you’re struggling and want support on your alcohol journey.
Panic attacks can be debilitating, like a wave that swallows us whole as we try to find our bearings — and “words of encouragement” tend to make things even worse. As Elyn Saks writes in The Center Cannot Hold: My Journey Through Madness, “In my experience, the words “now just calm down” almost inevitably have the opposite effect on the person you are speaking to.”
While there are many ways to relieve anxiety (more on that later!), for many of us, medications such as Xanax can serve as lifelines. But what about interactions of Xanax and alcohol? In particular, you might be wondering, “If I take Xanax in the morning, can I drink alcohol at night?” The short answer is — not really. It’s best not to risk it. But what are the dangers, exactly? Let’s find out!
Anxiety — when it reaches the level of panic attacks and impacts our daily lives — can be debilitating. It can cause problems at work (especially if our job involves presentations in front of large groups of people, meetings with clients, and even regular huddles with coworkers). It can put a strain on relationships, making us hesitant to accept invitations to weddings or weekend outings. It can steal valuable hours of sleep at night as we toss and turn, unable to get our mind to settle no matter how many sheep we count in our head.
And yet, anxiety is extremely common. In fact, according to the National Institute of Mental Health, over 19% of U.S. adults struggle with it! That’s almost one in five people at that board meeting or at least a couple of members of the wedding party — or a total of about 40 million people around the country. As physician Will Cronenwett tells TODAY.com:
“We live in an unsettled time … There’s inflation. The war. Stuff in the news. And we’re still dealing with COVID and what that did to our baseline anxiety levels … People feel less safe, and feeling unsafe about yourself in the world is similar to the feeling of anxiety disorder.”
For many, medication becomes a lifeline, and benzodiazepines such as lorazepam (Ativan), clonazepam (Klonopin), diazepam (Valium), and alprazolam (Xanax) have historically been some of the most popular. That said, they have their drawbacks — in particular, their sedating side effects and potential for addiction, which we’ll get into a bit later.
Like its benzodiazepine cousins, alprazolam (better known by its brand name Xanax) is frequently prescribed for panic attacks and anxiety disorders. Patented in 1971, Xanax was invented by Jackson Hester Jr. and has been on the medical scene in the U.S. since 1981. In 2021, it ranked 42nd on the “most commonly prescribed medication” list, with more than 15 million prescriptions doled out to (presumably) anxiety sufferers around the country.
Benzodiazepines (affectionately known as “benzos”) work by enhancing the effects of GABA — an inhibitory neurotransmitter in the brain. If this rings a bell, there’s a good reason — alcohol works through a similar mechanism by enhancing GABA and decreasing glutamate, its excitatory counterpart.
As far as benzos are concerned, Xanax is a bit of a “bad boy.” It has stronger effects on some and acts within minutes, with effects lasting between four to six hours. Because it’s more fast-acting than its counterparts, it has more potential for addiction, as well as a heavier presence “on the street.” As Cronenwett explains, “It tends to act quickly and wear off fairly quickly. Often people feel they need to use it more and more frequently. And then the thought of living without it becomes frightening. In some cases, it can begin to look like addiction.” It can also cause severe withdrawal symptoms, such as seizures, especially in those taking a large dose.
There are many slang terms for Xanax in popular culture. Top of the list? “Xannies,” or “Zannies.” Additionally, Xanax is sometimes referred to as “bars,” “ladders,” “footballs,” “planks,” “poles,” “sticks,” “blues,” or “blue footballs.” (All describing the physical shape of the pills, if you haven’t guessed it already.)
A 2022 documentary, Take Your Pills: Xanax, looks deep into the “soul” of this somewhat controversial medicine, describing it as “a cure for some and a curse for others.” Regardless of the path we take when it comes to Xanax alone, however, there’s definite trouble on the horizon when it comes to Xanax and alcohol interactions.
Can you drink on Xanax? Most people know better than to chase a pill with a shot of tequila. But what if we take it in the morning — does it make that margarita or round of beers after work off limits? The truth is, we’re better off staying away from booze for at least 24 hours after taking Xanax. Let’s dive into the reasons why mixing alcohol and Xanax could mean trouble, even with a time gap in between.
Both Xanax and alcohol are depressants that slow down the central nervous system. When we take them together, the depressant effects get amplified and could put us in danger. Here’s why:
In short, mixing two depressants isn’t worth the risk. But that’s not the end of the story!
In addition to excessive sedation, there are other side effects of Xanax that could linger for hours after our dose. Many of them don’t mix with alcohol, so drinking on the same night could be a recipe for trouble.
As we can see, the side effects of Xanax and alcohol together aren’t worth the risk. We’re better off avoiding the combo, and waiting until evening to drink doesn’t necessarily mean we’re in the clear.
When it comes to treating anxiety, Xanax and alcohol are not on the same team (even though they might initially appear to be). While it’s common to think of alcohol as “relaxing,” any relief we feel is the depressant effect at play. However, as the brain attempts to rebalance itself after being flooded with the reward neurotransmitter dopamine and GABA, it releases dynorphin — a neurochemical that is part of our brain's natural way of dampening down the feel-good response. It's like putting on the brakes when things are getting too rowdy. The result? We end up feeling more anxious than we did before.
That flood of dopamine we’ve mentioned a few times? Research shows that Xanax in particular triggers a hefty dose of dopamine to be released in the striatum (part of the reward center of the brain). While all benzodiazepines do so to some degree, alprazolam stands out among the rest. As a result, combining the two substances leads to a more intense dopamine flood — and more potential for dependence, as our brain starts to expect it as the “new normal.”
In fact, Xanax alone should be treated with caution, as far as dependence is concerned. According to NIDA, overdoses on benzos skyrocketed in the last couple of decades, rising from 1,135 in 1999 to 11,537 in 2017. After a brief decline to 9,711 deaths in 2019, overdoses were on the rise again, climbing to 12,499 by 2021. And with more potential for dependence than its chemical cousins, Xanax in particular is responsible for a large chunk of those numbers.
The combination of Xanax and alcohol also increases our chances of having an overdose. With alcohol in our system, the concentration of Xanax in our bloodstream gets higher. As a result, effects (such as sedation) get more pronounced.
Remember how we said it’s best to wait at least 24 hours after taking Xanax before having a drink? That’s because it typically takes about 11.2 hours for half of our Xanax dose to metabolize and leave our body. And given that we’re better off waiting until most of it has left our system, a full day is the way to go.
That said, there are many additional factors at play when it comes to determining the exact timing of when it might be safe to drink after taking Xanax.
All in all, mixing benzos and alcohol is risky business. Most doctors advise against drinking on any benzodiazepines, as the combo can be unpredictable, potentially causing severe side effects and complications.
Finally, here are some tips for reducing anxiety while staying safe when it comes to the Xanax and alcohol combo.
With these tips, you’ll be able to manage your anxiety better. You might find that you’re not even craving that drink at night after all! And remember, Reframe is always here to help if you’re struggling and want support on your alcohol journey.
Tums doesn’t interact with alcohol but together they can still be trouble. Check out our latest blog for more info on why mixing Tums with alcohol is not a good idea.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
“Whenever heartburn strikes, get fast relief with Tums,” a big voice booms in a Tums TV spot as a woman rushes across an airport terminal to fling her arms around ... a gigantic fried chicken nuggets-chili peppers-and onion wrap. “It’s time to Love Food Back!”
But will Tums let you “Love Booze Back”?
Since Tums can aid GI discomfort, many a wishful thinker would like to believe this heartburn remedy can relieve their misery following a lively night at the local bar. But no genie can fulfill that wish for the simple reason that alcohol works against Tums! Let’s learn why.
An over-the-counter (OTC) medication, Tums is used to treat indigestion, upset stomach, and heartburn. The active ingredient in Tums is calcium carbonate, which is a basic compound that works by neutralizing excess stomach acid. Excess stomach acid can cause GI discomfort such as nausea, pain, bloating, and heartburn. Tums is most commonly used as an antacid, but, as a mined calcium supplement, it’s also used to treat conditions such as hypocalcemia, gastroesophageal reflux disease (GERD), chronic kidney disease, and preeclampsia.
The medication is associated with a few common but not serious side effects.
Antacids like Tums are meant to relieve uncomfortable symptoms, but they may not address the root cause. Tums is effective for the tummy, but does it still work if we have a drink or two?
Tums and alcohol don’t have any known interactions. However, Tums and alcohol still have indirect interactions that can lead to adverse effects. Both substances pass through our GI system, which can impact absorption and metabolism and lead to negative effects.
Tums and alcohol don’t interact directly. However, they still have many potential indirect interactions that have negative consequences. If we’ve already had a drink, is it a good idea to take Tums?
There are no immediate dangers or direct interactions between alcohol and Tums. However, if we need to take Tums after drinking, we may be ignoring the bigger issue at hand.
Alcohol can promote increased stomach acid production. This can irritate the lining of the stomach and cause inflammation. Inflammation of the stomach can cause GI symptoms such as bloating, pain, and nausea. Excess gastric acid can also increase the risk of acid traveling up into our esophagus, which causes heartburn. Over time, alcohol can cause permanent damage to our GI system, which leads to long-term health conditions.
Taking Tums after drinking may temporarily relieve some GI discomfort. However, even though Tums may mitigate some uncomfortable symptoms, alcohol continues to damage our cells and tissues within our digestive tract, which can lead to long-term damage and GI conditions. It’s similar to using a band-aid to cover a wound that needs stitches. Taking Tums after drinking can provide a false sense that alcohol isn’t wreaking havoc on our GI system just because we may not be feeling discomfort at the moment.
If we’re trying to prevent GI discomfort, there is no set amount of alcohol that is confirmed not to cause any adverse effects. We’re all different and may respond differently to alcohol. Any amount of alcohol can disrupt our GI function, as alcohol passes through our digestive tract.
If we have additional risk factors, we may be more susceptible to GI distress from alcohol. Prolonged and excessive drinking can also have permanent effects on our gut microbiome. For this reason, excessive drinking is associated with conditions such as irritable bowel syndrome (IBS) and GERD.
No exact amount of alcohol is recommended when trying to prevent negative health effects. However, if we’re choosing to drink, it's best to follow moderate consumption guidelines to minimize any risks.
Since there are no direct interactions between alcohol and Tums, there is no specific time frame after taking Tums that makes alcohol safer to drink. If we’re taking Tums for GI discomfort or associated conditions unrelated to alcohol, drinking can negatively affect us no matter when we consume alcohol.
The half-life of Tums ranges from 6 to 9 hours. That means half of the medication is eliminated in that period. Therefore, it’s best to wait at least 18 hours after taking Tums to drink alcohol. While there aren’t any adverse effects from mixing the two, waiting to drink ensures that our GI discomfort isn’t being masked by the medication.
GI symptoms that Tums is used to relieve often can be recurring and caused by underlying conditions. Drinking alcohol while taking Tums and after the medication is eliminated may exacerbate symptoms and create greater complications and discomfort. If we experience regular GI discomfort, it may be best to avoid alcohol (with or without Tums in the equation). Tums doesn’t directly interact with alcohol, but what about other antacids?
Although other antacids may work like Tums, they may have different active ingredients that can negatively interact with alcohol. Since antacids relieve symptoms of GI discomfort, they’re often perceived to be solutions for side effects of drinking. However, antacids and alcohol aren’t always a good mix. Let’s take a look at how alcohol interacts with other common antacids.
Pepto-Bismol is another OTC medication used to treat diarrhea, heartburn, indigestion, and upset stomach. The active ingredient in Pepto-Bismol is bismuth subsalicylate, which has anti-inflammatory properties that reduce gastric irritation and diarrhea.
The medication works by coating the stomach lining, which acts as a barrier between our stomach and irritating substances. It also has antimicrobial effects — making it commonly prescribed for GI infections such as H. pylori.
Although Pepto-Bismol is used to treat symptoms similar to those Tums addresses, Pepto works differently and increases the risk of GI bleeding. Pepto-Bismol and alcohol are both metabolized by our liver, which can prioritize breaking down one toxic substance at a time.
Pepcid is a medication used to treat conditions caused by excess stomach acid and to prevent stomach ulcers. The medication is categorized as an H2 antagonist. H2 blockers bind to our histamine receptors and suppress the production of stomach acid-reducing histamine actions.
There are minimally reported interactions between alcohol and Pepcid. However, some studies have found that the medication may slightly increase the absorption of alcohol — increasing our blood alcohol concentration (BAC).
Despite the potential dangers, Pepcid and alcohol are often combined to reduce symptoms of alcohol flush. As an H2 blocker, Pepcid may reduce alcohol intolerance symptoms by suppressing histamine function. But, because Pepcid may reduce these important warning signs, it may open the door to more long-term effects of alcohol.
Alka-Seltzer Original is a combination of citric acid, aspirin, and sodium bicarbonate. The medication is used to treat GI symptoms that are accompanied by headaches or body aches.
There are many different forms of Alka-Seltzer, including an antacid variation, which is composed of anhydrous citric acid and sodium bicarbonate. Since the different types of Alka-Seltzer have different active ingredients, it’s important to check the medication for specific interactions with alcohol.
Alcohol directly interacts with aspirin, which is found in the Original form of Alka-Seltzer. It also can interact indirectly with sodium bicarbonate and lead to adverse effects. Drinking while taking Alka-Seltzer, no matter the type, isn’t recommended as it can increase the risk of complications and negative side effects.
Whichever antacid we may be taking, individual factors may make combining antacids with alcohol more dangerous. What are some risk factors to keep in mind?
Although Tums and alcohol don’t interact directly, their indirect interactions can still be harmful. On top of that, individual factors may make mixing the two more dangerous for us in comparison to others. Certain considerations can help us rethink the drink when taking Tums.
Generally speaking, Tums and alcohol aren’t a dangerous duo. However, individual risk factors and alcohol’s indirect effects on the symptoms Tums is used to treat can still cause adverse effects. How can we prevent or limit these effects?
Heartburn and other GI symptoms caused by excess stomach acid can be extremely uncomfortable. Tums can aid in relieving symptoms, but addressing the root causes may require a more comprehensive approach.
Antacids like Tums can manage heartburn and GI symptoms in the short term. However, other strategies may be needed to address long-term issues. Quitting or cutting back on alcohol helps limit exacerbating symptoms.
Tums is an antacid for treating conditions related to excess gastric acid and several other conditions. Although Tums and alcohol don’t have any direct interactions, drinking can still lead to negative health effects. Alcohol can exacerbate symptoms that Tums is used to treat and damage our digestive system in the long term. Antacids like Tums are sometimes used to relieve unpleasant symptoms of drinking. However, they can mask the detrimental effects of alcohol — leading to increased risk of health conditions.
“Whenever heartburn strikes, get fast relief with Tums,” a big voice booms in a Tums TV spot as a woman rushes across an airport terminal to fling her arms around ... a gigantic fried chicken nuggets-chili peppers-and onion wrap. “It’s time to Love Food Back!”
But will Tums let you “Love Booze Back”?
Since Tums can aid GI discomfort, many a wishful thinker would like to believe this heartburn remedy can relieve their misery following a lively night at the local bar. But no genie can fulfill that wish for the simple reason that alcohol works against Tums! Let’s learn why.
An over-the-counter (OTC) medication, Tums is used to treat indigestion, upset stomach, and heartburn. The active ingredient in Tums is calcium carbonate, which is a basic compound that works by neutralizing excess stomach acid. Excess stomach acid can cause GI discomfort such as nausea, pain, bloating, and heartburn. Tums is most commonly used as an antacid, but, as a mined calcium supplement, it’s also used to treat conditions such as hypocalcemia, gastroesophageal reflux disease (GERD), chronic kidney disease, and preeclampsia.
The medication is associated with a few common but not serious side effects.
Antacids like Tums are meant to relieve uncomfortable symptoms, but they may not address the root cause. Tums is effective for the tummy, but does it still work if we have a drink or two?
Tums and alcohol don’t have any known interactions. However, Tums and alcohol still have indirect interactions that can lead to adverse effects. Both substances pass through our GI system, which can impact absorption and metabolism and lead to negative effects.
Tums and alcohol don’t interact directly. However, they still have many potential indirect interactions that have negative consequences. If we’ve already had a drink, is it a good idea to take Tums?
There are no immediate dangers or direct interactions between alcohol and Tums. However, if we need to take Tums after drinking, we may be ignoring the bigger issue at hand.
Alcohol can promote increased stomach acid production. This can irritate the lining of the stomach and cause inflammation. Inflammation of the stomach can cause GI symptoms such as bloating, pain, and nausea. Excess gastric acid can also increase the risk of acid traveling up into our esophagus, which causes heartburn. Over time, alcohol can cause permanent damage to our GI system, which leads to long-term health conditions.
Taking Tums after drinking may temporarily relieve some GI discomfort. However, even though Tums may mitigate some uncomfortable symptoms, alcohol continues to damage our cells and tissues within our digestive tract, which can lead to long-term damage and GI conditions. It’s similar to using a band-aid to cover a wound that needs stitches. Taking Tums after drinking can provide a false sense that alcohol isn’t wreaking havoc on our GI system just because we may not be feeling discomfort at the moment.
If we’re trying to prevent GI discomfort, there is no set amount of alcohol that is confirmed not to cause any adverse effects. We’re all different and may respond differently to alcohol. Any amount of alcohol can disrupt our GI function, as alcohol passes through our digestive tract.
If we have additional risk factors, we may be more susceptible to GI distress from alcohol. Prolonged and excessive drinking can also have permanent effects on our gut microbiome. For this reason, excessive drinking is associated with conditions such as irritable bowel syndrome (IBS) and GERD.
No exact amount of alcohol is recommended when trying to prevent negative health effects. However, if we’re choosing to drink, it's best to follow moderate consumption guidelines to minimize any risks.
Since there are no direct interactions between alcohol and Tums, there is no specific time frame after taking Tums that makes alcohol safer to drink. If we’re taking Tums for GI discomfort or associated conditions unrelated to alcohol, drinking can negatively affect us no matter when we consume alcohol.
The half-life of Tums ranges from 6 to 9 hours. That means half of the medication is eliminated in that period. Therefore, it’s best to wait at least 18 hours after taking Tums to drink alcohol. While there aren’t any adverse effects from mixing the two, waiting to drink ensures that our GI discomfort isn’t being masked by the medication.
GI symptoms that Tums is used to relieve often can be recurring and caused by underlying conditions. Drinking alcohol while taking Tums and after the medication is eliminated may exacerbate symptoms and create greater complications and discomfort. If we experience regular GI discomfort, it may be best to avoid alcohol (with or without Tums in the equation). Tums doesn’t directly interact with alcohol, but what about other antacids?
Although other antacids may work like Tums, they may have different active ingredients that can negatively interact with alcohol. Since antacids relieve symptoms of GI discomfort, they’re often perceived to be solutions for side effects of drinking. However, antacids and alcohol aren’t always a good mix. Let’s take a look at how alcohol interacts with other common antacids.
Pepto-Bismol is another OTC medication used to treat diarrhea, heartburn, indigestion, and upset stomach. The active ingredient in Pepto-Bismol is bismuth subsalicylate, which has anti-inflammatory properties that reduce gastric irritation and diarrhea.
The medication works by coating the stomach lining, which acts as a barrier between our stomach and irritating substances. It also has antimicrobial effects — making it commonly prescribed for GI infections such as H. pylori.
Although Pepto-Bismol is used to treat symptoms similar to those Tums addresses, Pepto works differently and increases the risk of GI bleeding. Pepto-Bismol and alcohol are both metabolized by our liver, which can prioritize breaking down one toxic substance at a time.
Pepcid is a medication used to treat conditions caused by excess stomach acid and to prevent stomach ulcers. The medication is categorized as an H2 antagonist. H2 blockers bind to our histamine receptors and suppress the production of stomach acid-reducing histamine actions.
There are minimally reported interactions between alcohol and Pepcid. However, some studies have found that the medication may slightly increase the absorption of alcohol — increasing our blood alcohol concentration (BAC).
Despite the potential dangers, Pepcid and alcohol are often combined to reduce symptoms of alcohol flush. As an H2 blocker, Pepcid may reduce alcohol intolerance symptoms by suppressing histamine function. But, because Pepcid may reduce these important warning signs, it may open the door to more long-term effects of alcohol.
Alka-Seltzer Original is a combination of citric acid, aspirin, and sodium bicarbonate. The medication is used to treat GI symptoms that are accompanied by headaches or body aches.
There are many different forms of Alka-Seltzer, including an antacid variation, which is composed of anhydrous citric acid and sodium bicarbonate. Since the different types of Alka-Seltzer have different active ingredients, it’s important to check the medication for specific interactions with alcohol.
Alcohol directly interacts with aspirin, which is found in the Original form of Alka-Seltzer. It also can interact indirectly with sodium bicarbonate and lead to adverse effects. Drinking while taking Alka-Seltzer, no matter the type, isn’t recommended as it can increase the risk of complications and negative side effects.
Whichever antacid we may be taking, individual factors may make combining antacids with alcohol more dangerous. What are some risk factors to keep in mind?
Although Tums and alcohol don’t interact directly, their indirect interactions can still be harmful. On top of that, individual factors may make mixing the two more dangerous for us in comparison to others. Certain considerations can help us rethink the drink when taking Tums.
Generally speaking, Tums and alcohol aren’t a dangerous duo. However, individual risk factors and alcohol’s indirect effects on the symptoms Tums is used to treat can still cause adverse effects. How can we prevent or limit these effects?
Heartburn and other GI symptoms caused by excess stomach acid can be extremely uncomfortable. Tums can aid in relieving symptoms, but addressing the root causes may require a more comprehensive approach.
Antacids like Tums can manage heartburn and GI symptoms in the short term. However, other strategies may be needed to address long-term issues. Quitting or cutting back on alcohol helps limit exacerbating symptoms.
Tums is an antacid for treating conditions related to excess gastric acid and several other conditions. Although Tums and alcohol don’t have any direct interactions, drinking can still lead to negative health effects. Alcohol can exacerbate symptoms that Tums is used to treat and damage our digestive system in the long term. Antacids like Tums are sometimes used to relieve unpleasant symptoms of drinking. However, they can mask the detrimental effects of alcohol — leading to increased risk of health conditions.
Explore the efficacy and considerations of using phenobarbital in medication-assisted treatment for alcohol withdrawal, including its mechanism, benefits, and potential risks.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!
Alcohol withdrawal can be a severe and potentially life-threatening condition for individuals with chronic alcohol use disorder. Medication-assisted treatment (MAT) is a critical component in managing withdrawal symptoms and ensuring patient safety. Among the medications used, phenobarbital has garnered attention for its efficacy in treating alcohol withdrawal. This article explores the role of phenobarbital in MAT, its effectiveness, and important considerations for its use.
When a person with a history of heavy alcohol use suddenly stops drinking, their body can experience a range of withdrawal symptoms. These symptoms can vary from mild to severe and may include:
Severe withdrawal symptoms, particularly seizures and delirium tremens, can be life-threatening and require immediate medical intervention.
Phenobarbital is a barbiturate that has been used for decades to manage seizures and sedate patients. Its application in alcohol withdrawal treatment is based on its ability to enhance the inhibitory effects of gamma-aminobutyric acid (GABA) in the brain, which helps to counteract the hyperexcitability caused by alcohol withdrawal.
Phenobarbital works by increasing the activity of GABA, a neurotransmitter that inhibits nerve transmission in the brain, leading to a calming effect. During alcohol withdrawal, the brain is in a hyperexcitable state due to the sudden absence of alcohol, which previously enhanced GABA activity. By enhancing GABA activity, phenobarbital helps to stabilize the nervous system and reduce withdrawal symptoms.
Several studies have demonstrated the effectiveness of phenobarbital in managing alcohol withdrawal symptoms. It is particularly useful in preventing seizures and managing severe withdrawal symptoms such as delirium tremens. Phenobarbital's long half-life allows for less frequent dosing compared to other medications, which can improve patient compliance and reduce the risk of rebound symptoms.
A study conducted at a psychiatric hospital compared the use of phenobarbital to benzodiazepines for alcohol withdrawal management. The results indicated that phenobarbital was effective in reducing withdrawal symptoms and preventing seizures, with a similar safety profile to benzodiazepines.
Another study focused on outpatient treatment found that phenobarbital was effective in reducing withdrawal symptoms and preventing complications in patients with mild to moderate withdrawal. The study concluded that phenobarbital could be a viable alternative to benzodiazepines, particularly in settings where benzodiazepine use is contraindicated.
Phenobarbital dosage must be carefully titrated based on the severity of withdrawal symptoms and the patient's medical history. It is typically administered in a hospital or clinical setting where patients can be closely monitored. The initial dose is usually higher to rapidly control symptoms, followed by tapering doses to prevent rebound withdrawal.
While phenobarbital is effective, it is not without risks. Common side effects include drowsiness, dizziness, and ataxia. More severe side effects can include respiratory depression, especially when used in high doses or in combination with other sedatives. Therefore, it is crucial to monitor patients for signs of respiratory distress and other adverse effects.
Phenobarbital should be used with caution in patients with a history of substance abuse, respiratory disorders, or liver disease. It is also contraindicated in patients with a history of hypersensitivity to barbiturates. Due to its potential for dependence and abuse, phenobarbital should be prescribed and monitored by healthcare professionals experienced in managing alcohol withdrawal.
While phenobarbital is an effective option, it is not the only medication used for alcohol withdrawal. Benzodiazepines, such as diazepam and lorazepam, are commonly used and have a well-established safety profile. However, benzodiazepines carry a risk of dependence and may not be suitable for all patients.
Gabapentin, an anticonvulsant, has also been explored as a treatment for alcohol withdrawal. Studies have shown that gabapentin can be effective in reducing withdrawal symptoms, particularly in outpatient settings. It has a lower risk of dependence compared to benzodiazepines and phenobarbital, making it a suitable option for some patients. For more information, you can read about Gabapentin for Alcohol Withdrawal.
Phenobarbital plays a significant role in the medication-assisted treatment of alcohol withdrawal, particularly for managing severe symptoms and preventing seizures. Its efficacy, coupled with its long half-life, makes it a valuable option for both inpatient and outpatient settings. However, careful consideration must be given to its dosage, potential side effects, and patient-specific factors to ensure safe and effective treatment.
For individuals seeking to build healthier drinking habits and reframe their relationship with alcohol, understanding the options available for managing withdrawal is crucial. If you or a loved one is struggling with alcohol withdrawal, it is essential to seek professional medical advice to determine the most appropriate treatment plan.
Alcohol withdrawal can be a severe and potentially life-threatening condition for individuals with chronic alcohol use disorder. Medication-assisted treatment (MAT) is a critical component in managing withdrawal symptoms and ensuring patient safety. Among the medications used, phenobarbital has garnered attention for its efficacy in treating alcohol withdrawal. This article explores the role of phenobarbital in MAT, its effectiveness, and important considerations for its use.
When a person with a history of heavy alcohol use suddenly stops drinking, their body can experience a range of withdrawal symptoms. These symptoms can vary from mild to severe and may include:
Severe withdrawal symptoms, particularly seizures and delirium tremens, can be life-threatening and require immediate medical intervention.
Phenobarbital is a barbiturate that has been used for decades to manage seizures and sedate patients. Its application in alcohol withdrawal treatment is based on its ability to enhance the inhibitory effects of gamma-aminobutyric acid (GABA) in the brain, which helps to counteract the hyperexcitability caused by alcohol withdrawal.
Phenobarbital works by increasing the activity of GABA, a neurotransmitter that inhibits nerve transmission in the brain, leading to a calming effect. During alcohol withdrawal, the brain is in a hyperexcitable state due to the sudden absence of alcohol, which previously enhanced GABA activity. By enhancing GABA activity, phenobarbital helps to stabilize the nervous system and reduce withdrawal symptoms.
Several studies have demonstrated the effectiveness of phenobarbital in managing alcohol withdrawal symptoms. It is particularly useful in preventing seizures and managing severe withdrawal symptoms such as delirium tremens. Phenobarbital's long half-life allows for less frequent dosing compared to other medications, which can improve patient compliance and reduce the risk of rebound symptoms.
A study conducted at a psychiatric hospital compared the use of phenobarbital to benzodiazepines for alcohol withdrawal management. The results indicated that phenobarbital was effective in reducing withdrawal symptoms and preventing seizures, with a similar safety profile to benzodiazepines.
Another study focused on outpatient treatment found that phenobarbital was effective in reducing withdrawal symptoms and preventing complications in patients with mild to moderate withdrawal. The study concluded that phenobarbital could be a viable alternative to benzodiazepines, particularly in settings where benzodiazepine use is contraindicated.
Phenobarbital dosage must be carefully titrated based on the severity of withdrawal symptoms and the patient's medical history. It is typically administered in a hospital or clinical setting where patients can be closely monitored. The initial dose is usually higher to rapidly control symptoms, followed by tapering doses to prevent rebound withdrawal.
While phenobarbital is effective, it is not without risks. Common side effects include drowsiness, dizziness, and ataxia. More severe side effects can include respiratory depression, especially when used in high doses or in combination with other sedatives. Therefore, it is crucial to monitor patients for signs of respiratory distress and other adverse effects.
Phenobarbital should be used with caution in patients with a history of substance abuse, respiratory disorders, or liver disease. It is also contraindicated in patients with a history of hypersensitivity to barbiturates. Due to its potential for dependence and abuse, phenobarbital should be prescribed and monitored by healthcare professionals experienced in managing alcohol withdrawal.
While phenobarbital is an effective option, it is not the only medication used for alcohol withdrawal. Benzodiazepines, such as diazepam and lorazepam, are commonly used and have a well-established safety profile. However, benzodiazepines carry a risk of dependence and may not be suitable for all patients.
Gabapentin, an anticonvulsant, has also been explored as a treatment for alcohol withdrawal. Studies have shown that gabapentin can be effective in reducing withdrawal symptoms, particularly in outpatient settings. It has a lower risk of dependence compared to benzodiazepines and phenobarbital, making it a suitable option for some patients. For more information, you can read about Gabapentin for Alcohol Withdrawal.
Phenobarbital plays a significant role in the medication-assisted treatment of alcohol withdrawal, particularly for managing severe symptoms and preventing seizures. Its efficacy, coupled with its long half-life, makes it a valuable option for both inpatient and outpatient settings. However, careful consideration must be given to its dosage, potential side effects, and patient-specific factors to ensure safe and effective treatment.
For individuals seeking to build healthier drinking habits and reframe their relationship with alcohol, understanding the options available for managing withdrawal is crucial. If you or a loved one is struggling with alcohol withdrawal, it is essential to seek professional medical advice to determine the most appropriate treatment plan.
Have you heard that drinking while on lithium is strongly discouraged? Check out our latest blog to learn more about the dangerous effects of mixing alcohol and lithium.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
After reading the pamphlet with the paragraphs of tiny text that the pharmacist handed you with your lithium prescription, you may still be scratching your head. While the warnings do advise against drinking alcohol, they’re not exactly clear. Can you still drink alcohol while taking lithium?
Let’s take a closer look at the interactions between alcohol and lithium.
Lithium compounds such as lithium carbonate and lithium citrate are approved by the Federal Drug Administration (FDA) as prescription medications to treat bipolar disorder and other mood disorders. They act as mood stabilizers, which can help regulate changes between high mood (mania) and low mood (depression).
While most commonly used to treat bipolar disorder, lithium also hasbeen used off-label for neutropenia, depression, vascular headaches, Huntington’s disease, and more.
Despite its various uses, all forms of lithium are known for their delayed initial onset. According to the National Health Service (NHS), lithium can take anywhere from a week to months to take effect when it is taken initially.
Once lithium takes effect, its half-life ranges from 18-36 hours, implying that a single dose can stay in our system for up to 72 hours. However, we don’t see the peak effects of lithium until about five hours after ingestion, depending on the form and dosage. To maintain consistent efficacy throughout the day, doctors prescribe lithium to be taken at regular intervals.
This means that our first dose will still be lingering in our system when it’s time to take the second dose, which is why it’s difficult to pinpoint exactly how long it takes our body to eliminate lithium. It may take a week or more to be eliminated. So, is it okay to drink after a week of not taking lithium?
Before we’re able to determine if we can drink during and after taking lithium, let’s first understand how alcohol can interfere with our mood, which lithium is commonly prescribed to help regulate.
Alcohol affects our mood through chemical messengers in our brain known as neurotransmitters. Serotonin and dopamine are two of the main neurotransmitters that affect our mood.
After drinking, as our body metabolizes and eliminates alcohol, our serotonin and dopamine levels dip, causing more drastic fluctuations in our mood.
Over time, excessive and prolonged drinking can lead to permanent changes in our brain chemistry. Our brain will produce less serotonin and dopamine, which can prolong periods of low mood. Long-term alcohol use is also connected to impairments in our hypothalamic-pituitary-adrenal (HPA) axis, which can decrease our stress tolerance — increasing the risk of more drastic fluctuations in our mood.
These changes in our brain chemistry explain why long-term drinking is associated with mental health conditions such as anxiety, depression, and more. Alcohol and lithium both impact our mood, but how do they interact with each other?
Alcohol interacts with many drugs, including lithium. To determine if we can drink alcohol while taking lithium, let’s better understand the direct interactions between the two.
Alcohol and lithium interact in many different ways, so is it still okay to drink?
Drinking alcohol while taking lithium can be extremely dangerous. This is largely because lithium has a narrow therapeutic index, meaning there’s a small window between an effective dose and a toxic dose of lithium. Even subtle changes in fluid levels caused by drinking alcohol can lead to lithium toxicity — a life-threatening condition.
A study reviewing patients who were admitted to a psychiatric hospital found that 6.8% of patients being administered lithium had toxic levels of lithium at some point during their treatment. This is without any alcohol and in a highly controlled hospital setting. Adding alcohol into the equation (even one drink) can greatly increase the risk of lithium toxicity or other adverse effects.
But what if it’s just one drink? Since alcohol affects each of us differently, it’s difficult to determine a safe amount of alcohol that can be consumed without experiencing any negative effects. It’s best to avoid drinking altogether. Let’s take a closer look at the associated risks.
When alcohol interacts with lithium, our body can experience varying adverse effects. There are four direct consequences of drinking while taking lithium.
While taking lithium, alcohol can lead to many complications, but what about after discontinuing the medication?
The dangers of drinking after discontinuing lithium are less clear than while taking the medication. However, due to alcohol’s negative effects on our mood, it’s not advisable to drink even after discontinuing lithium.
If we choose to drink, it’s best to first consult with a physician. After discontinuing lithium, it may take some time before it’s completely eliminated from our system — making us susceptible to lithium toxicity. Depending on individual circumstances, other medications may also be prescribed — opening the door to other drug interactions. Drinking after taking lithium and while on the medication is not recommended, so how should we go about it?
Lithium and alcohol go together like oil and water. However, with alcohol being such a large aspect of our social culture, we may be faced with the choice of whether or not we should drink when taking lithium. If the situation does arise, there are ways we can prioritize our health and safety.
By following these tips, we can navigate lithium and alcohol consumption safely.
Warning labels on lithium medication may not be entirely clear on whether or not drinking is okay while taking these medications. However, a closer look at the interaction between lithium and alcohol reveals that drinking while taking lithium can lead to serious adverse effects — even in minimal amounts. Fortunately, healthy alternatives and support when needed can help us approach lithium and alcohol safely.
After reading the pamphlet with the paragraphs of tiny text that the pharmacist handed you with your lithium prescription, you may still be scratching your head. While the warnings do advise against drinking alcohol, they’re not exactly clear. Can you still drink alcohol while taking lithium?
Let’s take a closer look at the interactions between alcohol and lithium.
Lithium compounds such as lithium carbonate and lithium citrate are approved by the Federal Drug Administration (FDA) as prescription medications to treat bipolar disorder and other mood disorders. They act as mood stabilizers, which can help regulate changes between high mood (mania) and low mood (depression).
While most commonly used to treat bipolar disorder, lithium also hasbeen used off-label for neutropenia, depression, vascular headaches, Huntington’s disease, and more.
Despite its various uses, all forms of lithium are known for their delayed initial onset. According to the National Health Service (NHS), lithium can take anywhere from a week to months to take effect when it is taken initially.
Once lithium takes effect, its half-life ranges from 18-36 hours, implying that a single dose can stay in our system for up to 72 hours. However, we don’t see the peak effects of lithium until about five hours after ingestion, depending on the form and dosage. To maintain consistent efficacy throughout the day, doctors prescribe lithium to be taken at regular intervals.
This means that our first dose will still be lingering in our system when it’s time to take the second dose, which is why it’s difficult to pinpoint exactly how long it takes our body to eliminate lithium. It may take a week or more to be eliminated. So, is it okay to drink after a week of not taking lithium?
Before we’re able to determine if we can drink during and after taking lithium, let’s first understand how alcohol can interfere with our mood, which lithium is commonly prescribed to help regulate.
Alcohol affects our mood through chemical messengers in our brain known as neurotransmitters. Serotonin and dopamine are two of the main neurotransmitters that affect our mood.
After drinking, as our body metabolizes and eliminates alcohol, our serotonin and dopamine levels dip, causing more drastic fluctuations in our mood.
Over time, excessive and prolonged drinking can lead to permanent changes in our brain chemistry. Our brain will produce less serotonin and dopamine, which can prolong periods of low mood. Long-term alcohol use is also connected to impairments in our hypothalamic-pituitary-adrenal (HPA) axis, which can decrease our stress tolerance — increasing the risk of more drastic fluctuations in our mood.
These changes in our brain chemistry explain why long-term drinking is associated with mental health conditions such as anxiety, depression, and more. Alcohol and lithium both impact our mood, but how do they interact with each other?
Alcohol interacts with many drugs, including lithium. To determine if we can drink alcohol while taking lithium, let’s better understand the direct interactions between the two.
Alcohol and lithium interact in many different ways, so is it still okay to drink?
Drinking alcohol while taking lithium can be extremely dangerous. This is largely because lithium has a narrow therapeutic index, meaning there’s a small window between an effective dose and a toxic dose of lithium. Even subtle changes in fluid levels caused by drinking alcohol can lead to lithium toxicity — a life-threatening condition.
A study reviewing patients who were admitted to a psychiatric hospital found that 6.8% of patients being administered lithium had toxic levels of lithium at some point during their treatment. This is without any alcohol and in a highly controlled hospital setting. Adding alcohol into the equation (even one drink) can greatly increase the risk of lithium toxicity or other adverse effects.
But what if it’s just one drink? Since alcohol affects each of us differently, it’s difficult to determine a safe amount of alcohol that can be consumed without experiencing any negative effects. It’s best to avoid drinking altogether. Let’s take a closer look at the associated risks.
When alcohol interacts with lithium, our body can experience varying adverse effects. There are four direct consequences of drinking while taking lithium.
While taking lithium, alcohol can lead to many complications, but what about after discontinuing the medication?
The dangers of drinking after discontinuing lithium are less clear than while taking the medication. However, due to alcohol’s negative effects on our mood, it’s not advisable to drink even after discontinuing lithium.
If we choose to drink, it’s best to first consult with a physician. After discontinuing lithium, it may take some time before it’s completely eliminated from our system — making us susceptible to lithium toxicity. Depending on individual circumstances, other medications may also be prescribed — opening the door to other drug interactions. Drinking after taking lithium and while on the medication is not recommended, so how should we go about it?
Lithium and alcohol go together like oil and water. However, with alcohol being such a large aspect of our social culture, we may be faced with the choice of whether or not we should drink when taking lithium. If the situation does arise, there are ways we can prioritize our health and safety.
By following these tips, we can navigate lithium and alcohol consumption safely.
Warning labels on lithium medication may not be entirely clear on whether or not drinking is okay while taking these medications. However, a closer look at the interaction between lithium and alcohol reveals that drinking while taking lithium can lead to serious adverse effects — even in minimal amounts. Fortunately, healthy alternatives and support when needed can help us approach lithium and alcohol safely.
Nortriptyline treats both depression and chronic pain. Alcohol makes both these conditions worse, so mixing it with nortriptyline is a bad idea. Read our latest blog to find out more!
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
Raise your hand if you’ve ever taken a shot of whiskey to fix that toothache or chronic pain in your foot. Or turned to a fruity cocktail to bring you up when you’re feeling down. Sound familiar? Well, you’re not alone. Depression and chronic pain are common conditions, and they have some things in common: they’re persistent, and they’re both associated with alcohol use as a relief (it’s not actually a true or sustainable relief, but rather an illusion that results in greater pain in the long run). There is one particular medication that handles both of these conditions: nortriptyline.
Nortriptyline (or Pamelor) is a medication used primarily to treat depression and pain (especially nerve pain). It can also be used for anxiety, ADHD, and smoking cessation. When taken for depression, it’s typically taken for months or years until the depression is under control, depending on the person. Let’s take a look at some side effects of Pamelor.
Like any other medication, nortriptyline comes with side effects.
More serious side effects are quite rare but do happen.
If you experience any of the more serious ones, tell your doctor right away. A change in dose might be necessary to get relief.
That’s all good to know, but for our purposes, we’re wondering if we can drink on nortriptyline. In fact, this particular combination, while not lethal, still poses a risk to our body.
Nortriptyline doesn’t start working right away. If we’re taking it for pain relief, it can take a week or so to kick in. For depression, nortriptyline can take up to 6 weeks to see results. For this reason, it’s best to avoid alcohol for at least 6 weeks to make sure the medication is working and the dose is right. If we do drink while taking nortriptyline, we should only drink in moderation. This means women shouldn’t have more than 1 drink on any given day or more than 8 per week while men should consume no more than 2 drinks per day or 15 per week.
Mixing alcohol with any medication is dangerous. That said, mixing nortriptyline with alcohol is less dangerous than many other combinations, but should still be avoided because of its potential to increase the side effects of both substances, as well as make nortriptyline’s benefits less effective.
Mixing nortriptyline with alcohol can worsen its side effects, ranging from fatigue to liver damage.
Another reason to avoid alcohol use while taking nortriptyline, particularly if we’re taking it for depression, is because alcohol by itself can cause depression. Remember how we said alcohol affects our brain chemistry? Well, that’s where the depression comes in. If we’re already depressed, alcohol can worsen depression because it alters the way our brain produces chemicals such as dopamine and serotonin (our “feel-good” chemicals). In fact, people with alcohol use disorder (AUD) often have a depression disorder as well, although it’s often hard to tell which came first once we get into a cycle of drinking when we’re depressed. Even if we don’t already have depression, drinking regularly, especially heavy drinking, affects our brain chemistry in a way that makes us feel depressed because alcohol affects our mood, memory, and decision-making ability.
One study revealed that if we have either AUD or a depression disorder, our risk for developing the other one is doubled. They also found that AUD increases our risk of depression more than the other way around, as most of the study participants already had AUD before they noticed depression symptoms.
Discover more about the connection between alcohol and depression in our blog “Alcohol Misuse and Depression: What’s the Connection?”
Besides depression, nortriptyline is also used to treat nerve pain. While many people use alcohol to numb physical pain, this actually doesn’t work the way we think it does. Chronic alcohol consumption can result in alcoholic neuropathy — or nerve damage that causes chronic pain. The condition is reversible in some cases, but better to not let it get out of hand. And alcohol can even alter the way the brain processes pain signals. In some cases, people with AUD develop allodynia, a type of nerve pain many describe as sharp, stinging, or burning. Alcohol withdrawal can also cause allodynia, as well as other pain sensitivity.
Since nortriptyline treats multiple conditions, bringing alcohol into the mix affects our treatment in more ways than one. Mixing alcohol with nortriptyline makes both depression and pain worse. By cutting back or quitting our alcohol consumption, we can tackle both problems naturally at the same time.
Let’s say we’re feeling great and decide to stop taking nortriptyline. Can we drink right away? It turns out, we can’t just stop taking nortriptyline all of a sudden. Typically, we need to gradually decrease our dosage to prevent withdrawal symptoms such as muscle pain or fatigue. Consuming alcohol right after stopping nortriptyline is still not a good idea because we have it in our system for about a week after our last dose. Also, it increases our risk of redeveloping the conditions of depression and chronic pain that we were trying to treat in the first place. For more information about alcohol and antidepressants, check out our blog “Alcohol and Antidepressants: A Dangerous Combo”.
There are several things we can do while taking nortriptyline to manage both pain and depression.
Depression and chronic pain may seem like insurmountable conditions to live with, but remember, you can find healthy ways to cope with these conditions. Your brain is capable of incredible change, and you can harness its power to improve both your physical and mental well-being. With positive lifestyle changes and an open mind, you can live the happy, pain-free life you’ve always wanted, and you won’t need booze to get there! Whether you’re on medication or not, by avoiding alcohol you’re setting yourself up for success in managing many conditions, and why not give yourself that chance? The team here at Reframe is ready to help you every step of the way!
Raise your hand if you’ve ever taken a shot of whiskey to fix that toothache or chronic pain in your foot. Or turned to a fruity cocktail to bring you up when you’re feeling down. Sound familiar? Well, you’re not alone. Depression and chronic pain are common conditions, and they have some things in common: they’re persistent, and they’re both associated with alcohol use as a relief (it’s not actually a true or sustainable relief, but rather an illusion that results in greater pain in the long run). There is one particular medication that handles both of these conditions: nortriptyline.
Nortriptyline (or Pamelor) is a medication used primarily to treat depression and pain (especially nerve pain). It can also be used for anxiety, ADHD, and smoking cessation. When taken for depression, it’s typically taken for months or years until the depression is under control, depending on the person. Let’s take a look at some side effects of Pamelor.
Like any other medication, nortriptyline comes with side effects.
More serious side effects are quite rare but do happen.
If you experience any of the more serious ones, tell your doctor right away. A change in dose might be necessary to get relief.
That’s all good to know, but for our purposes, we’re wondering if we can drink on nortriptyline. In fact, this particular combination, while not lethal, still poses a risk to our body.
Nortriptyline doesn’t start working right away. If we’re taking it for pain relief, it can take a week or so to kick in. For depression, nortriptyline can take up to 6 weeks to see results. For this reason, it’s best to avoid alcohol for at least 6 weeks to make sure the medication is working and the dose is right. If we do drink while taking nortriptyline, we should only drink in moderation. This means women shouldn’t have more than 1 drink on any given day or more than 8 per week while men should consume no more than 2 drinks per day or 15 per week.
Mixing alcohol with any medication is dangerous. That said, mixing nortriptyline with alcohol is less dangerous than many other combinations, but should still be avoided because of its potential to increase the side effects of both substances, as well as make nortriptyline’s benefits less effective.
Mixing nortriptyline with alcohol can worsen its side effects, ranging from fatigue to liver damage.
Another reason to avoid alcohol use while taking nortriptyline, particularly if we’re taking it for depression, is because alcohol by itself can cause depression. Remember how we said alcohol affects our brain chemistry? Well, that’s where the depression comes in. If we’re already depressed, alcohol can worsen depression because it alters the way our brain produces chemicals such as dopamine and serotonin (our “feel-good” chemicals). In fact, people with alcohol use disorder (AUD) often have a depression disorder as well, although it’s often hard to tell which came first once we get into a cycle of drinking when we’re depressed. Even if we don’t already have depression, drinking regularly, especially heavy drinking, affects our brain chemistry in a way that makes us feel depressed because alcohol affects our mood, memory, and decision-making ability.
One study revealed that if we have either AUD or a depression disorder, our risk for developing the other one is doubled. They also found that AUD increases our risk of depression more than the other way around, as most of the study participants already had AUD before they noticed depression symptoms.
Discover more about the connection between alcohol and depression in our blog “Alcohol Misuse and Depression: What’s the Connection?”
Besides depression, nortriptyline is also used to treat nerve pain. While many people use alcohol to numb physical pain, this actually doesn’t work the way we think it does. Chronic alcohol consumption can result in alcoholic neuropathy — or nerve damage that causes chronic pain. The condition is reversible in some cases, but better to not let it get out of hand. And alcohol can even alter the way the brain processes pain signals. In some cases, people with AUD develop allodynia, a type of nerve pain many describe as sharp, stinging, or burning. Alcohol withdrawal can also cause allodynia, as well as other pain sensitivity.
Since nortriptyline treats multiple conditions, bringing alcohol into the mix affects our treatment in more ways than one. Mixing alcohol with nortriptyline makes both depression and pain worse. By cutting back or quitting our alcohol consumption, we can tackle both problems naturally at the same time.
Let’s say we’re feeling great and decide to stop taking nortriptyline. Can we drink right away? It turns out, we can’t just stop taking nortriptyline all of a sudden. Typically, we need to gradually decrease our dosage to prevent withdrawal symptoms such as muscle pain or fatigue. Consuming alcohol right after stopping nortriptyline is still not a good idea because we have it in our system for about a week after our last dose. Also, it increases our risk of redeveloping the conditions of depression and chronic pain that we were trying to treat in the first place. For more information about alcohol and antidepressants, check out our blog “Alcohol and Antidepressants: A Dangerous Combo”.
There are several things we can do while taking nortriptyline to manage both pain and depression.
Depression and chronic pain may seem like insurmountable conditions to live with, but remember, you can find healthy ways to cope with these conditions. Your brain is capable of incredible change, and you can harness its power to improve both your physical and mental well-being. With positive lifestyle changes and an open mind, you can live the happy, pain-free life you’ve always wanted, and you won’t need booze to get there! Whether you’re on medication or not, by avoiding alcohol you’re setting yourself up for success in managing many conditions, and why not give yourself that chance? The team here at Reframe is ready to help you every step of the way!
Is it safe to take melatonin when you’re drinking alcohol? Learn the risks of mixing alcohol and melatonin.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
It’s already late, and you’ve been out drinking with friends. The night’s winding down, and you opt to crash at your friend’s place. After taking a last sip of red wine, she offers you a melatonin. She takes one, too, and you say goodnight. You don’t think much of it — it’s just a supplement, right?
However, as you crawl into bed and lie down, you start to feel strange. The next morning you feel nauseous, too. Is it a hangover, or more? Is it safe to mix melatonin with alcohol? Find out the facts as we explore this common question together.
First off, what exactly is melatonin? Most of us are familiar with melatonin supplements, but melatonin is actually a hormone our brain produces in response to darkness. Melatonin helps with the timing of our circadian rhythm (our body’s internal clock) and with our sleep pattern. Ever wondered why it can be so difficult to fall asleep when there’s a bright light shining through the curtains? Being exposed to light or brightness at night can block our natural melatonin production, which is why blackout curtains are so necessary for many of us.
Melatonin is produced by our pineal gland, which is located in the middle of our brain. This gland is controlled by the suprachiasmatic nucleus (SCN). The SCN is a group of neurons, or nerve cells, that control our body’s clock by sending signals to each other.
During the day, the retina in our eyes absorbs light and sends signals to the SCN. Then, the SCN tells our pineal gland to stop making melatonin. This helps us to stay awake and alert. The opposite happens at night. When we’re exposed to darkness, our SCN activates the pineal gland, which then releases melatonin. Because the hormone melatonin helps us fall asleep, melatonin supplements are commonly recommended for those of us who struggle to sleep for a variety of reasons:
Basically, if our body struggles to produce enough melatonin to fall asleep, the supplements can help fill in the gap so we can get our much-needed Zs.
Melatonin is associated with many risks and potential side effects even without adding alcohol into the mix:
To prevent daytime sleepiness, grogginess, or other potential side effects, be sure to take melatonin in the early evening or hours before bed, and only take the recommended dosage on the label. If you’re unsure, talk with your healthcare provider about the dosage. Melatonin can stay in our system for up to 4-5 hours, so we should plan ahead when taking it.
Alcohol is a depressant drug that reduces communication between our brain and body, leading to impaired coordination and slowed reaction time. Taken in excess, it can lead to numerous negative health effects, including depression, coma, and even death.
Considering the multitude of potential risks associated with taking melatonin and those associated with drinking alcohol, it should come as no surprise that mixing alcohol with melatonin is dangerous.
Taking melatonin with alcohol presents many problems, both short term and long term:
If the goal of taking melatonin is to get better sleep and feel more rested, it’s worth noting that many of these side effects would defeat the purpose of taking melatonin in the first place.
But perhaps more worrisome are the effects on our liver. The combination of melatonin and alcohol is especially hard on our liver, which presents its own set of complications:
The bottom line is that the effects of alcohol can be amplified by melatonin and vice versa. If you experience any of these more serious side effects, see your doctor or seek emergency help.
But despite these potential side effects, some of us are still probably wondering: Can I take melatonin after having just one glass of wine or a beer?
The answer is you can, but we still don’t recommend it. If you do choose to have one drink before taking melatonin, use caution.
Keep in mind that many melatonin supplements are time-released. This means they can take some time to begin working. Many of them begin working about 30 minutes after you’ve taken them. Having an alcoholic drink interrupts this process and can make the supplement not work as well and lead to a host of potential negative side effects.
In addition to the side effects of melatonin listed above, there are other health risks to keep in mind:
In summary, it’s best to skip the booze when you know you’re going to be taking melatonin to sleep. We hope you feel extra informed and aware now when it comes to melatonin in general and the next time you’re thinking about taking it with a drink, we hope you grab a mocktail or other non-alcoholic drink instead.
It’s already late, and you’ve been out drinking with friends. The night’s winding down, and you opt to crash at your friend’s place. After taking a last sip of red wine, she offers you a melatonin. She takes one, too, and you say goodnight. You don’t think much of it — it’s just a supplement, right?
However, as you crawl into bed and lie down, you start to feel strange. The next morning you feel nauseous, too. Is it a hangover, or more? Is it safe to mix melatonin with alcohol? Find out the facts as we explore this common question together.
First off, what exactly is melatonin? Most of us are familiar with melatonin supplements, but melatonin is actually a hormone our brain produces in response to darkness. Melatonin helps with the timing of our circadian rhythm (our body’s internal clock) and with our sleep pattern. Ever wondered why it can be so difficult to fall asleep when there’s a bright light shining through the curtains? Being exposed to light or brightness at night can block our natural melatonin production, which is why blackout curtains are so necessary for many of us.
Melatonin is produced by our pineal gland, which is located in the middle of our brain. This gland is controlled by the suprachiasmatic nucleus (SCN). The SCN is a group of neurons, or nerve cells, that control our body’s clock by sending signals to each other.
During the day, the retina in our eyes absorbs light and sends signals to the SCN. Then, the SCN tells our pineal gland to stop making melatonin. This helps us to stay awake and alert. The opposite happens at night. When we’re exposed to darkness, our SCN activates the pineal gland, which then releases melatonin. Because the hormone melatonin helps us fall asleep, melatonin supplements are commonly recommended for those of us who struggle to sleep for a variety of reasons:
Basically, if our body struggles to produce enough melatonin to fall asleep, the supplements can help fill in the gap so we can get our much-needed Zs.
Melatonin is associated with many risks and potential side effects even without adding alcohol into the mix:
To prevent daytime sleepiness, grogginess, or other potential side effects, be sure to take melatonin in the early evening or hours before bed, and only take the recommended dosage on the label. If you’re unsure, talk with your healthcare provider about the dosage. Melatonin can stay in our system for up to 4-5 hours, so we should plan ahead when taking it.
Alcohol is a depressant drug that reduces communication between our brain and body, leading to impaired coordination and slowed reaction time. Taken in excess, it can lead to numerous negative health effects, including depression, coma, and even death.
Considering the multitude of potential risks associated with taking melatonin and those associated with drinking alcohol, it should come as no surprise that mixing alcohol with melatonin is dangerous.
Taking melatonin with alcohol presents many problems, both short term and long term:
If the goal of taking melatonin is to get better sleep and feel more rested, it’s worth noting that many of these side effects would defeat the purpose of taking melatonin in the first place.
But perhaps more worrisome are the effects on our liver. The combination of melatonin and alcohol is especially hard on our liver, which presents its own set of complications:
The bottom line is that the effects of alcohol can be amplified by melatonin and vice versa. If you experience any of these more serious side effects, see your doctor or seek emergency help.
But despite these potential side effects, some of us are still probably wondering: Can I take melatonin after having just one glass of wine or a beer?
The answer is you can, but we still don’t recommend it. If you do choose to have one drink before taking melatonin, use caution.
Keep in mind that many melatonin supplements are time-released. This means they can take some time to begin working. Many of them begin working about 30 minutes after you’ve taken them. Having an alcoholic drink interrupts this process and can make the supplement not work as well and lead to a host of potential negative side effects.
In addition to the side effects of melatonin listed above, there are other health risks to keep in mind:
In summary, it’s best to skip the booze when you know you’re going to be taking melatonin to sleep. We hope you feel extra informed and aware now when it comes to melatonin in general and the next time you’re thinking about taking it with a drink, we hope you grab a mocktail or other non-alcoholic drink instead.
Should you stay away from alcohol while taking Sudafed? Find out why combining the two can amp up the side effects and create a gnarly mix.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
There’s a meme that describes the problem of sinus infections to a T: “You just don’t appreciate breathing out of both nostrils until one suddenly is taken away from you.” And boy, does that ring true!
Many of us find that Sudafed can be a godsend when it comes to clearing up congestion. But what happens if we add alcohol to the mix? Can you drink on Sudafed? What are the interactions between the active ingredient, pseudoephedrine, and alcohol? Let’s find out!
The active ingredient in Sudafed — pseudoephedrine — has raised some eyebrows over the years, but remains an effective way to clear up that pesky sinus congestion. Structurally similar to the more potent ephedrine, it’s a stimulant from the phenethylamine and amphetamine chemical classes.
Both pseudoephedrine and ephedrine are found naturally in the ephedra plant, which has a long history of medicinal use in Eastern traditions. It works by shrinking swollen mucous membranes in the nose, reducing congestion that often comes with colds or allergies. While it is widely used and generally safe (when used correctly), it can also have some gnarly side effects:
Some folks misuse the drug for its stimulant properties, which can cause even more side effects. Even worse, some will use it to “cook” methamphetamines. This is why you have to show an ID to get it at the drugstore.
Now that we have a better idea of what Sudafed is and how it works, we can see why mixing it with booze is asking for trouble. The combination can cause many problems, mentally and physically.
Since alcohol is a depressant and Sudafed is a stimulant, the combination of the two confuses our central nervous system and cardiovascular system, compounding symptoms:
While a single drink taken with Sudafed probably won’t harm you, it’s never a good idea to mix the two, since we don’t know exactly where the line between safety and harm is. There are lots of factors involved, such as age, metabolism, genetics, what you’ve eaten that day, and what other medications you might be taking. It’s always best to stay on the safe side! Besides, the side effects of the mix, as well as the fact that your symptoms might get worse, would probably make the experience pretty unpleasant.
Finally, here’s a bit of advice for taking Sudafed and staying away from booze in the meantime (or even longer!).
Life has its ups and downs, but adding artificial ones by mixing Sudafed and alcohol can spell trouble. Instead, let’s focus on taking care of our mind and body and discover healthier ways to manage our mood and relax, especially as we heal from an illness. There’s plenty of booze-free fun to be had whether we’re currently taking Sudafed or we reach the other side of whatever has us taking it in the first place.
There’s a meme that describes the problem of sinus infections to a T: “You just don’t appreciate breathing out of both nostrils until one suddenly is taken away from you.” And boy, does that ring true!
Many of us find that Sudafed can be a godsend when it comes to clearing up congestion. But what happens if we add alcohol to the mix? Can you drink on Sudafed? What are the interactions between the active ingredient, pseudoephedrine, and alcohol? Let’s find out!
The active ingredient in Sudafed — pseudoephedrine — has raised some eyebrows over the years, but remains an effective way to clear up that pesky sinus congestion. Structurally similar to the more potent ephedrine, it’s a stimulant from the phenethylamine and amphetamine chemical classes.
Both pseudoephedrine and ephedrine are found naturally in the ephedra plant, which has a long history of medicinal use in Eastern traditions. It works by shrinking swollen mucous membranes in the nose, reducing congestion that often comes with colds or allergies. While it is widely used and generally safe (when used correctly), it can also have some gnarly side effects:
Some folks misuse the drug for its stimulant properties, which can cause even more side effects. Even worse, some will use it to “cook” methamphetamines. This is why you have to show an ID to get it at the drugstore.
Now that we have a better idea of what Sudafed is and how it works, we can see why mixing it with booze is asking for trouble. The combination can cause many problems, mentally and physically.
Since alcohol is a depressant and Sudafed is a stimulant, the combination of the two confuses our central nervous system and cardiovascular system, compounding symptoms:
While a single drink taken with Sudafed probably won’t harm you, it’s never a good idea to mix the two, since we don’t know exactly where the line between safety and harm is. There are lots of factors involved, such as age, metabolism, genetics, what you’ve eaten that day, and what other medications you might be taking. It’s always best to stay on the safe side! Besides, the side effects of the mix, as well as the fact that your symptoms might get worse, would probably make the experience pretty unpleasant.
Finally, here’s a bit of advice for taking Sudafed and staying away from booze in the meantime (or even longer!).
Life has its ups and downs, but adding artificial ones by mixing Sudafed and alcohol can spell trouble. Instead, let’s focus on taking care of our mind and body and discover healthier ways to manage our mood and relax, especially as we heal from an illness. There’s plenty of booze-free fun to be had whether we’re currently taking Sudafed or we reach the other side of whatever has us taking it in the first place.
Antihistamines and alcohol are not a great mix, and hydroxyzine is no exception. Find out why in our latest blog!
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
Maybe those seasonal allergies have you sneezing and rubbing your eyes. For some reason, Benadryl just doesn’t cut it, and neither do its second-generation, over-the-counter cousins. Commuters in the train slide away from you thinking you must have a cold, while coworkers give you looks of concern (were you just crying in our morning meeting?).
Or, maybe, life has been stressful lately and you find yourself binge- watching YouTube videos night after night, unable to go to sleep. You know antidepressants and prescription sleep meds are an option, but you’re hesitant to go that route yet.
Is there anything that could help? For many people, it’s hydroxyzine (better known as Vistaril). Developed as an antihistamine, it has gained a reputation as a fairly mild and “user-friendly” antianxiety and insomnia aid. It’s also fairly common for doctors to prescribe hydroxyzine for alcohol withdrawal symptoms. But what about combining hydroxyzine with alcohol? Let’s find out!
Hydroxyzine (Vistaril) is a prescription antihistamine that works by blocking histamine — a substance produced by the body during allergic reactions.
The side effects tend to be pretty mild:
Like many other sedating antihistamines (think Benadryl or Dramamine), hydroxyzine inhibits the action of a neurotransmitter called acetylcholine, which is responsible for memory, learning, motivation, stimulation, and motor control. As a drug class, these anticholinergic medications can cause blurry vision, confusion, urinary retention, and constipation. For that reason, hydroxyzine is generally not prescribed to folks over 65, who might be more sensitive to these effects.
Despite being developed as an antihistamine, hydroxyzine has a couple of other tricks up its sleeve: in addition to blocking histamine, hydroxyzine is a bronchodilator (it opens up our airways) and an antiemetic (keeps us from throwing up), and it’s sometimes used as a mild, fast-acting, antianxiety medication. Because of its versatility, it’s one of the most commonly prescribed drugs in the United States, with nearly 3.4 million Americans taking it as of 2021.
As a result of its somewhat unusual chemical profile and relatively mild side effects, hydroxyzine is a bit more sophisticated than your run-of-the-mill antihistamine. As mentioned earlier, it’s a triple-tasker in the medical arena:
So how does this versatile medication act differently when alcohol is in the mix?
In general, combining alcohol and antihistamines isn’t a good idea, mainly since alcohol enhances the sedative effects while boosting some of the chemical processes that cause allergic reactions in the first place. (For an in-depth look, check out our blog “Can I Drink Alcohol While Taking Allergy Medication?”)
It’s important to note just how impairing some sedating antihistamines truly are. A study in the Annals of Internal Medicine compared driving performance of people taking Benadryl (a first-generation antihistamine) or Allegra (its second-generation cousin) for hay fever with those who had alcohol or a placebo. The subjects were sent off on a pretend road trip in the Iowa Driving Simulator. The result? Those on Benadryl did worse than the subjects who were legally drunk!
Talking about the study, author John Weiler explains, “First-generation antihistamines, such as diphenhydramine, are known to affect driving performance. However, we were surprised to find that this antihistamine has more impact on driving performance than alcohol does.” He goes on to say that "drowsiness was only weakly associated with minimum following distance, steering instability and crossing into the left lane … These results suggest that people should carefully read warning labels on all medications. Even if you do not feel drowsy after taking an antihistamine or alcohol, you may be impaired."
As with other antihistamines, mixing hydroxyzine with alcohol is not a good idea. There are three big reasons for this:
Probably nothing too drastic, but we never know where that line is, so it’s best to err on the side of safety and stay away from booze if you’re taking hydroxyzine.
If you’ve already combined the two and you’re here after a panicked web search, fear not. Start by taking a deep breath (that’s important!). If you’ve had only a couple drinks, took a normal dose of hydroxyzine, and have no known heart issues, you aren’t in serious danger. Rest, take it easy, and stay in bed or on the couch — now isn’t the time to cook a meal, rearrange furniture, or go for a drive.
Stay aware of your body. Notice if you feel like you’re having trouble breathing or if your heart rate starts feeling like it’s playing jazz instead of beating regularly. You’re likely going to be very tired, so it may be best to ask a family member or partner to check in on you for a few hours. If anything feels troubling, seek immediate medical care.
If you’ve had a lot to drink and you took a hydroxyzine dose higher than normal, or if you have a heart rhythm disorder that prolongs your QT interval, seek immediate medical care.
Combining small amounts of alcohol and hydroxyzine isn’t likely to kill us, but it’s definitely not good for us. It increases the chance of something dangerous happening, and when we do this regularly, it can cause chronic damage to our body.
Whatever condition we’re taking hydroxyzine for, chances are alcohol isn’t doing us any favors when it comes to getting relief. There’s scientific evidence proving that booze has a negative impact on all three conditions we might be taking hydroxyzine for: allergies, anxiety, and insomnia.
Finally, what about using hydroxyzine for alcohol withdrawal? Indeed, it’s one of the ways doctors help patients reduce anxiety and tremors associated with suddenly stopping alcohol use. The neurochemical trainwreck alcohol leaves in its wake manifests as intense anxiety and the notorious “shakes” that sometimes escalate into full-blown seizures. To make this period a bit more comfortable, benzodiazepines are often the go-to form of treatment. One major problem? They’re just as addictive as alcohol itself.
Antihistamines, on the other hand, offer a safer alternative. An article from the Encyclopedia of Sleep explains, “Antihistamines are commonly used in alleviation of insomnia in drug and alcohol withdrawal where traditional GABA-acting hypnotics are less suitable due to the risk of cross-dependence, although there have been no controlled trials in this setting.”
Finally, here are a few tips for staying safe when it comes to alcohol and hydroxyzine.
All in all, dealing with allergies, anxiety, and insomnia alike is no picnic — and there are plenty of people who share your struggles and sympathize. But adding alcohol to the mix is bound to make things even tougher in the long run. Instead, try to see this situation as an opportunity to explore what true wellness is all about. As A.J. Jacobs writes in Drop Dead Healthy: One Man's Humble Quest for Bodily Perfection, “The key to making healthy decisions is to respect your future self. Honor him or her. Treat him or her like you would treat a friend or a loved one.”
Maybe those seasonal allergies have you sneezing and rubbing your eyes. For some reason, Benadryl just doesn’t cut it, and neither do its second-generation, over-the-counter cousins. Commuters in the train slide away from you thinking you must have a cold, while coworkers give you looks of concern (were you just crying in our morning meeting?).
Or, maybe, life has been stressful lately and you find yourself binge- watching YouTube videos night after night, unable to go to sleep. You know antidepressants and prescription sleep meds are an option, but you’re hesitant to go that route yet.
Is there anything that could help? For many people, it’s hydroxyzine (better known as Vistaril). Developed as an antihistamine, it has gained a reputation as a fairly mild and “user-friendly” antianxiety and insomnia aid. It’s also fairly common for doctors to prescribe hydroxyzine for alcohol withdrawal symptoms. But what about combining hydroxyzine with alcohol? Let’s find out!
Hydroxyzine (Vistaril) is a prescription antihistamine that works by blocking histamine — a substance produced by the body during allergic reactions.
The side effects tend to be pretty mild:
Like many other sedating antihistamines (think Benadryl or Dramamine), hydroxyzine inhibits the action of a neurotransmitter called acetylcholine, which is responsible for memory, learning, motivation, stimulation, and motor control. As a drug class, these anticholinergic medications can cause blurry vision, confusion, urinary retention, and constipation. For that reason, hydroxyzine is generally not prescribed to folks over 65, who might be more sensitive to these effects.
Despite being developed as an antihistamine, hydroxyzine has a couple of other tricks up its sleeve: in addition to blocking histamine, hydroxyzine is a bronchodilator (it opens up our airways) and an antiemetic (keeps us from throwing up), and it’s sometimes used as a mild, fast-acting, antianxiety medication. Because of its versatility, it’s one of the most commonly prescribed drugs in the United States, with nearly 3.4 million Americans taking it as of 2021.
As a result of its somewhat unusual chemical profile and relatively mild side effects, hydroxyzine is a bit more sophisticated than your run-of-the-mill antihistamine. As mentioned earlier, it’s a triple-tasker in the medical arena:
So how does this versatile medication act differently when alcohol is in the mix?
In general, combining alcohol and antihistamines isn’t a good idea, mainly since alcohol enhances the sedative effects while boosting some of the chemical processes that cause allergic reactions in the first place. (For an in-depth look, check out our blog “Can I Drink Alcohol While Taking Allergy Medication?”)
It’s important to note just how impairing some sedating antihistamines truly are. A study in the Annals of Internal Medicine compared driving performance of people taking Benadryl (a first-generation antihistamine) or Allegra (its second-generation cousin) for hay fever with those who had alcohol or a placebo. The subjects were sent off on a pretend road trip in the Iowa Driving Simulator. The result? Those on Benadryl did worse than the subjects who were legally drunk!
Talking about the study, author John Weiler explains, “First-generation antihistamines, such as diphenhydramine, are known to affect driving performance. However, we were surprised to find that this antihistamine has more impact on driving performance than alcohol does.” He goes on to say that "drowsiness was only weakly associated with minimum following distance, steering instability and crossing into the left lane … These results suggest that people should carefully read warning labels on all medications. Even if you do not feel drowsy after taking an antihistamine or alcohol, you may be impaired."
As with other antihistamines, mixing hydroxyzine with alcohol is not a good idea. There are three big reasons for this:
Probably nothing too drastic, but we never know where that line is, so it’s best to err on the side of safety and stay away from booze if you’re taking hydroxyzine.
If you’ve already combined the two and you’re here after a panicked web search, fear not. Start by taking a deep breath (that’s important!). If you’ve had only a couple drinks, took a normal dose of hydroxyzine, and have no known heart issues, you aren’t in serious danger. Rest, take it easy, and stay in bed or on the couch — now isn’t the time to cook a meal, rearrange furniture, or go for a drive.
Stay aware of your body. Notice if you feel like you’re having trouble breathing or if your heart rate starts feeling like it’s playing jazz instead of beating regularly. You’re likely going to be very tired, so it may be best to ask a family member or partner to check in on you for a few hours. If anything feels troubling, seek immediate medical care.
If you’ve had a lot to drink and you took a hydroxyzine dose higher than normal, or if you have a heart rhythm disorder that prolongs your QT interval, seek immediate medical care.
Combining small amounts of alcohol and hydroxyzine isn’t likely to kill us, but it’s definitely not good for us. It increases the chance of something dangerous happening, and when we do this regularly, it can cause chronic damage to our body.
Whatever condition we’re taking hydroxyzine for, chances are alcohol isn’t doing us any favors when it comes to getting relief. There’s scientific evidence proving that booze has a negative impact on all three conditions we might be taking hydroxyzine for: allergies, anxiety, and insomnia.
Finally, what about using hydroxyzine for alcohol withdrawal? Indeed, it’s one of the ways doctors help patients reduce anxiety and tremors associated with suddenly stopping alcohol use. The neurochemical trainwreck alcohol leaves in its wake manifests as intense anxiety and the notorious “shakes” that sometimes escalate into full-blown seizures. To make this period a bit more comfortable, benzodiazepines are often the go-to form of treatment. One major problem? They’re just as addictive as alcohol itself.
Antihistamines, on the other hand, offer a safer alternative. An article from the Encyclopedia of Sleep explains, “Antihistamines are commonly used in alleviation of insomnia in drug and alcohol withdrawal where traditional GABA-acting hypnotics are less suitable due to the risk of cross-dependence, although there have been no controlled trials in this setting.”
Finally, here are a few tips for staying safe when it comes to alcohol and hydroxyzine.
All in all, dealing with allergies, anxiety, and insomnia alike is no picnic — and there are plenty of people who share your struggles and sympathize. But adding alcohol to the mix is bound to make things even tougher in the long run. Instead, try to see this situation as an opportunity to explore what true wellness is all about. As A.J. Jacobs writes in Drop Dead Healthy: One Man's Humble Quest for Bodily Perfection, “The key to making healthy decisions is to respect your future self. Honor him or her. Treat him or her like you would treat a friend or a loved one.”
