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2024-05-30 9:00
Alcohol and Medications
Can You Drink Alcohol on Epclusa?
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Alcohol doesn’t have any direct interactions with Epclusa but can still have negative effects. Check out our latest blog for more info on mixing the two.

16 min read

Maintain a Healthy Liver With Help From Reframe!

Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually, with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!

The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.

You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.

Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol. 

And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).

The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!

Read Full Article  →

We commonly hear that alcohol can be harmful to our liver, which is why those of us with hepatitis C are advised to avoid alcohol. But what about during the treatment of hepatitis C?

Epclusa, a medication frequently prescribed for hepatitis C surprisingly doesn’t state any direct interactions with alcohol. Does this mean it’s ok to drink while taking Epclusa? Not quite. Let’s examine how Epclusa’s mechanism works and how it can indirectly interact with alcohol.

What Is Epclusa?

A woman holding a glass of alcohol with pills on the table

Epclusa is the brand name medication for the combination of the drugs sofosbuvir and velpatasvir. The combination of drugs that make up Epclusa is FDA-approved to treat all six hepatitis genotypes. 

Sofosbuvir, one of the components of Epclusa, blocks the enzyme NS5B, which interferes with the reproduction of the virus within our genetic material. Velpatasvir, the other component in Epclusa, blocks the protein NS5A that prevents the virus from replicating. Together, they’re categorized as a direct-acting antiviral that stops hepatitis C from multiplying and infecting new cells. 

The medication is commonly prescribed for chronic hepatitis C and can be used for patients with or without cirrhosis (liver damage). Epclusa is a daily medication that is prescribed for a 12-week period to help treat hepatitis C.

Epclusa Side Effects

Epclusa, like most medications, is associated with a range of side effects. Common side effects of Epclusa include the following:

  • Fatigue
  • Headache
  • Nausea
  • Insomnia
  • Muscle weakness
  • Irritability

Less common and more severe side effects include the following:

  • Hepatitis B reactivation
  • Allergic reaction
  • Depression
  • Jaundice
  • Stomach pain

To determine if drinking on Epclusa is a good idea, let’s first get a better understanding of the condition the medication is used to treat — hepatitis C.

Understanding Hepatitis C 

Hepatitis C is a viral infection that causes liver inflammation and infection. Untreated, hepatitis C can lead to liver damage (cirrhosis) and liver cancer. According to the Centers for Disease Control and Prevention (CDC), chronic hepatitis C is the leading cause of liver transplants.

The hepatitis C virus is spread through the blood and can cause both acute and chronic illness. Common symptoms of hepatitis C include the following:

  • Fever
  • Fatigue
  • Loss of appetite
  • Nausea and vomiting
  • Abdominal pain
  • Dark urine
  • Jaundice

Unlike hepatitis A and B which can be prevented through vaccines, hepatitis C doesn’t have a vaccine and is treated through antivirals. Treatment is crucial, as the CDC reported 15,713 hepatitis C-related deaths in 2018, which is believed to be an underestimate. Epclusa reports a 98% cure rate, but can drinking while taking the medication affect it?

The Interaction Between Alcohol and Epclusa

No direct interactions between alcohol and Epclusa have been reported. This means that alcohol won’t directly change Epclusa’s mechanisms in how it prevents the hepatitis C virus from multiplying. 

Studies have found, however, that alcohol worsens hepatitis C. Furthermore, a study on hepatitis C and alcohol concluded that alcohol consumption can increase the risk of developing fibrosis and cirrhosis in hepatitis C patients. A different study reported similar findings and also found that heavy alcohol use impeded patients’ responses to treatment for hepatitis C.

Since Epclusa treats hepatitis C, could it block the damage that alcohol causes to the virus? 

Can You Drink Alcohol While on Epclusa?

While alcohol and Epclusa don’t have strict contraindications or direct interactions, it still isn’t a good idea to drink while taking the medication. 

Although alcohol may not directly impact the effectiveness of Epclusa, alcohol’s effects on the systems in our body can indirectly impact the medication and treatment of hepatitis C. That being said, is one drink ok while taking Epclusa?

How Much Alcohol Is Too Much?

Since alcohol affects each of us differently depending on individual factors, it’s impossible to determine a safe amount that won’t interfere with hepatitis C treatment. 

Most studies review the effects of heavy drinking on hepatitis C, but this analysis of findings from multiple studies shows that moderate drinking can also cause the progression of the disease. Let’s further examine the potential risks of mixing alcohol and Epclusa. 

Consequences of Drinking While on Epclusa

Negative Effects of Drinking on Epclusa

Alcohol’s toxic effects on our organs and systems can indirectly affect Epclusa. Some negative effects of drinking while taking Epclusa include the following:

  • Increased side effects. Side effects from drinking and Epclusa can overlap — causing exacerbated symptoms. This may include pounding headaches, nausea, diarrhea, and fatigue.

  • Increase the risk of liver damage. Hepatitis C and alcohol use are associated with liver inflammation. Excessive drinking and ineffective treatment for hepatitis C can increase liver damage and scarring, which can lead to liver failure.
  • Interfere with treatment regimen. Alcohol can also affect our inhibitions and judgment — interfering with our ability to adhere to the medication regimen of Epclusa. Taking the medication daily is crucial in ensuring the virus isn’t able to multiply and affect new cells.

Drinking while taking Epclusa isn’t recommended, but what about after discontinuing the medication? 

Can You Drink After Taking Epclusa?

Although drinking after stopping Epclusa does not impact hepatitis C treatment and may have fewer side effects, it is still not advisable.

Since alcohol is linked to lowered inhibitions and decreased judgment, it increases the chance of participating in risky behaviors like sharing needles and participating in unsafe sex. Given that the hepatitis C virus is transmitted through contaminated blood, individuals engaging in these activities may likely be at a greater risk of contracting and transmitting hepatitis C.

Alcohol not only increases the risk of contracting hepatitis C, it can also continue to worsen our liver function. Although Epclusa may treat hepatitis C and prevent further damage to our liver from the virus, alcohol also directly harms the liver — increasing the risk of liver disease and liver cancer. Drinking while taking Epclusa and after stopping Epclusa can both have adverse effects. That being said, should we panic if we’ve already had a drink?

What To Do if You Drink on Epclusa

If we’ve already unknowingly had a drink, there’s no reason to panic. In fact, panicking will increase our stress levels, which can aggravate many diseases and pathological conditions. There are five simple steps we can take if we’ve had a drink while taking Epclusa:

  1. Stop drinking. One drink may not have immediate harm, but if we continue to drink, it opens the door to increased complications and potential consequences. To prevent any further harm, it's best to stop drinking now that we better understand the consequences. 
  2. Monitor symptoms. Intoxication and Epclusa can cause side effects. Although we may not always experience side effects, it can be a good idea to look out for them and keep track. This way we can watch out for any dangerous symptoms and consult with a physician if needed. 
  3. Consult with a physician. Since many individual factors can impact the way alcohol and Epclusa affect us, consulting with a physician can give us more personalized medical advice. Some of us may be at higher risk or be taking other medications that can directly interact with alcohol. Consulting with a physician is our safest bet.
  4. Continue medication. It’s important to continue taking Epclusa as it’s prescribed. This helps to maximize the effectiveness of the medication and stop the hepatitis C virus from multiplying and spreading. 

  5. Seek emergency treatment. Dangerous symptoms aren’t commonly reported but can still happen. If you experience any severe symptoms from drinking, taking Epclusa, or both, it's best to seek emergency medical treatment. In the US, call 911 for medical/safety emergencies.

It’s important to remember that not all harmful effects will be visible to us. Although we may not always experience immediate effects, alcohol is a toxic substance that can affect our body in ways we can’t see. To prevent the risk of complications, let’s review some ways we can navigate Epculsa and alcohol more intentionally.

Approaching Epclusa and Alcohol Consumption Safely

Although Epclusa and alcohol don’t have any direct interactions, mixing the two can open the door to increased complications and potential risks. Some ways we can prioritize our health and safety include the following mindful drinking practices:

  • Find alternatives. Alcohol-free alternatives can be a great option for those of us who may want to continue participating in the social aspect of drinking. Try a new mocktail recipe or explore non-alcoholic options at the bar to stay on track with Epclusa treatment. 
  • Be mindful of other interactions. Epclusa has direct interactions with other medications and so does alcohol. If we take any other prescription or over-the-counter medications, it’s important to check for interactions.
  • Prioritize liver health. Hepatitis C and alcohol can be extremely damaging to our liver. Taking care of our liver health through quitting or cutting back on alcohol and other toxic substances can help prevent further liver damage. 
  • Consult with a physician. We may have individual risk factors and reach Epclusa or alcohol differently. Consulting with a doctor regarding our personal needs can help us get personalized treatment to ensure our safety and well-being.

Hepatitis C is unpleasant but can be effectively treated with Epclusa. To give us the best chance to fight back against the virus, quitting or cutting back on alcohol is the best course of action.

To Sum it Up

Epclusa is an effective treatment for chronic hepatitis C that can be affected by alcohol, although indirectly. Drinking may not change the way Epclusa inhibits the spreading of the hepatitis C virus, but it can add to the progression of the condition and negatively affect treatment. To set us up for success, it’s best to quit or cut back on alcohol while taking Epclusa. Give hepatitis C the boot by avoiding mixing alcohol and Epclusa.

We commonly hear that alcohol can be harmful to our liver, which is why those of us with hepatitis C are advised to avoid alcohol. But what about during the treatment of hepatitis C?

Epclusa, a medication frequently prescribed for hepatitis C surprisingly doesn’t state any direct interactions with alcohol. Does this mean it’s ok to drink while taking Epclusa? Not quite. Let’s examine how Epclusa’s mechanism works and how it can indirectly interact with alcohol.

What Is Epclusa?

A woman holding a glass of alcohol with pills on the table

Epclusa is the brand name medication for the combination of the drugs sofosbuvir and velpatasvir. The combination of drugs that make up Epclusa is FDA-approved to treat all six hepatitis genotypes. 

Sofosbuvir, one of the components of Epclusa, blocks the enzyme NS5B, which interferes with the reproduction of the virus within our genetic material. Velpatasvir, the other component in Epclusa, blocks the protein NS5A that prevents the virus from replicating. Together, they’re categorized as a direct-acting antiviral that stops hepatitis C from multiplying and infecting new cells. 

The medication is commonly prescribed for chronic hepatitis C and can be used for patients with or without cirrhosis (liver damage). Epclusa is a daily medication that is prescribed for a 12-week period to help treat hepatitis C.

Epclusa Side Effects

Epclusa, like most medications, is associated with a range of side effects. Common side effects of Epclusa include the following:

  • Fatigue
  • Headache
  • Nausea
  • Insomnia
  • Muscle weakness
  • Irritability

Less common and more severe side effects include the following:

  • Hepatitis B reactivation
  • Allergic reaction
  • Depression
  • Jaundice
  • Stomach pain

To determine if drinking on Epclusa is a good idea, let’s first get a better understanding of the condition the medication is used to treat — hepatitis C.

Understanding Hepatitis C 

Hepatitis C is a viral infection that causes liver inflammation and infection. Untreated, hepatitis C can lead to liver damage (cirrhosis) and liver cancer. According to the Centers for Disease Control and Prevention (CDC), chronic hepatitis C is the leading cause of liver transplants.

The hepatitis C virus is spread through the blood and can cause both acute and chronic illness. Common symptoms of hepatitis C include the following:

  • Fever
  • Fatigue
  • Loss of appetite
  • Nausea and vomiting
  • Abdominal pain
  • Dark urine
  • Jaundice

Unlike hepatitis A and B which can be prevented through vaccines, hepatitis C doesn’t have a vaccine and is treated through antivirals. Treatment is crucial, as the CDC reported 15,713 hepatitis C-related deaths in 2018, which is believed to be an underestimate. Epclusa reports a 98% cure rate, but can drinking while taking the medication affect it?

The Interaction Between Alcohol and Epclusa

No direct interactions between alcohol and Epclusa have been reported. This means that alcohol won’t directly change Epclusa’s mechanisms in how it prevents the hepatitis C virus from multiplying. 

Studies have found, however, that alcohol worsens hepatitis C. Furthermore, a study on hepatitis C and alcohol concluded that alcohol consumption can increase the risk of developing fibrosis and cirrhosis in hepatitis C patients. A different study reported similar findings and also found that heavy alcohol use impeded patients’ responses to treatment for hepatitis C.

Since Epclusa treats hepatitis C, could it block the damage that alcohol causes to the virus? 

Can You Drink Alcohol While on Epclusa?

While alcohol and Epclusa don’t have strict contraindications or direct interactions, it still isn’t a good idea to drink while taking the medication. 

Although alcohol may not directly impact the effectiveness of Epclusa, alcohol’s effects on the systems in our body can indirectly impact the medication and treatment of hepatitis C. That being said, is one drink ok while taking Epclusa?

How Much Alcohol Is Too Much?

Since alcohol affects each of us differently depending on individual factors, it’s impossible to determine a safe amount that won’t interfere with hepatitis C treatment. 

Most studies review the effects of heavy drinking on hepatitis C, but this analysis of findings from multiple studies shows that moderate drinking can also cause the progression of the disease. Let’s further examine the potential risks of mixing alcohol and Epclusa. 

Consequences of Drinking While on Epclusa

Negative Effects of Drinking on Epclusa

Alcohol’s toxic effects on our organs and systems can indirectly affect Epclusa. Some negative effects of drinking while taking Epclusa include the following:

  • Increased side effects. Side effects from drinking and Epclusa can overlap — causing exacerbated symptoms. This may include pounding headaches, nausea, diarrhea, and fatigue.

  • Increase the risk of liver damage. Hepatitis C and alcohol use are associated with liver inflammation. Excessive drinking and ineffective treatment for hepatitis C can increase liver damage and scarring, which can lead to liver failure.
  • Interfere with treatment regimen. Alcohol can also affect our inhibitions and judgment — interfering with our ability to adhere to the medication regimen of Epclusa. Taking the medication daily is crucial in ensuring the virus isn’t able to multiply and affect new cells.

Drinking while taking Epclusa isn’t recommended, but what about after discontinuing the medication? 

Can You Drink After Taking Epclusa?

Although drinking after stopping Epclusa does not impact hepatitis C treatment and may have fewer side effects, it is still not advisable.

Since alcohol is linked to lowered inhibitions and decreased judgment, it increases the chance of participating in risky behaviors like sharing needles and participating in unsafe sex. Given that the hepatitis C virus is transmitted through contaminated blood, individuals engaging in these activities may likely be at a greater risk of contracting and transmitting hepatitis C.

Alcohol not only increases the risk of contracting hepatitis C, it can also continue to worsen our liver function. Although Epclusa may treat hepatitis C and prevent further damage to our liver from the virus, alcohol also directly harms the liver — increasing the risk of liver disease and liver cancer. Drinking while taking Epclusa and after stopping Epclusa can both have adverse effects. That being said, should we panic if we’ve already had a drink?

What To Do if You Drink on Epclusa

If we’ve already unknowingly had a drink, there’s no reason to panic. In fact, panicking will increase our stress levels, which can aggravate many diseases and pathological conditions. There are five simple steps we can take if we’ve had a drink while taking Epclusa:

  1. Stop drinking. One drink may not have immediate harm, but if we continue to drink, it opens the door to increased complications and potential consequences. To prevent any further harm, it's best to stop drinking now that we better understand the consequences. 
  2. Monitor symptoms. Intoxication and Epclusa can cause side effects. Although we may not always experience side effects, it can be a good idea to look out for them and keep track. This way we can watch out for any dangerous symptoms and consult with a physician if needed. 
  3. Consult with a physician. Since many individual factors can impact the way alcohol and Epclusa affect us, consulting with a physician can give us more personalized medical advice. Some of us may be at higher risk or be taking other medications that can directly interact with alcohol. Consulting with a physician is our safest bet.
  4. Continue medication. It’s important to continue taking Epclusa as it’s prescribed. This helps to maximize the effectiveness of the medication and stop the hepatitis C virus from multiplying and spreading. 

  5. Seek emergency treatment. Dangerous symptoms aren’t commonly reported but can still happen. If you experience any severe symptoms from drinking, taking Epclusa, or both, it's best to seek emergency medical treatment. In the US, call 911 for medical/safety emergencies.

It’s important to remember that not all harmful effects will be visible to us. Although we may not always experience immediate effects, alcohol is a toxic substance that can affect our body in ways we can’t see. To prevent the risk of complications, let’s review some ways we can navigate Epculsa and alcohol more intentionally.

Approaching Epclusa and Alcohol Consumption Safely

Although Epclusa and alcohol don’t have any direct interactions, mixing the two can open the door to increased complications and potential risks. Some ways we can prioritize our health and safety include the following mindful drinking practices:

  • Find alternatives. Alcohol-free alternatives can be a great option for those of us who may want to continue participating in the social aspect of drinking. Try a new mocktail recipe or explore non-alcoholic options at the bar to stay on track with Epclusa treatment. 
  • Be mindful of other interactions. Epclusa has direct interactions with other medications and so does alcohol. If we take any other prescription or over-the-counter medications, it’s important to check for interactions.
  • Prioritize liver health. Hepatitis C and alcohol can be extremely damaging to our liver. Taking care of our liver health through quitting or cutting back on alcohol and other toxic substances can help prevent further liver damage. 
  • Consult with a physician. We may have individual risk factors and reach Epclusa or alcohol differently. Consulting with a doctor regarding our personal needs can help us get personalized treatment to ensure our safety and well-being.

Hepatitis C is unpleasant but can be effectively treated with Epclusa. To give us the best chance to fight back against the virus, quitting or cutting back on alcohol is the best course of action.

To Sum it Up

Epclusa is an effective treatment for chronic hepatitis C that can be affected by alcohol, although indirectly. Drinking may not change the way Epclusa inhibits the spreading of the hepatitis C virus, but it can add to the progression of the condition and negatively affect treatment. To set us up for success, it’s best to quit or cut back on alcohol while taking Epclusa. Give hepatitis C the boot by avoiding mixing alcohol and Epclusa.

Alcohol and Medications
2024-05-27 9:00
Alcohol and Medications
What Happens If You Mix Phentermine and Alcohol?
This is some text inside of a div block.

Can you drink alcohol while taking phentermine? Science says it’s not the best idea. Find out why in our latest blog!

20 min read

Ready To Power Your Weight Loss Journey by Drinking Less? Reframe Can Help!

Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!

The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.

You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.

Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol. 

And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).

The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today! 

Read Full Article  →

When it comes to losing weight, there are all types of solutions out there. And while it’s not for everyone, medication can help. Among the many options, phentermine (known by the brand name Adipex) is a favorite for some thanks to its powerful hunger-blocking cues. That muffin in the bakery shop window? No longer enticing. Extra helping of mashed potatoes at Thanksgiving? No thanks.

But what about that glass of wine? Can you drink on phentermine? What are the dangers of combining Adipex and alcohol? Let’s find out!

What Is Phentermine?

A glass of whiskey and pills

Phentermine acts like a sort of neurological amp, increasing the signals of fullness in the brain and dialing down the hunger cues. 

According to Drugbank.com, phentermine came onto the scene in 1959 as an anti-obesity drug and became widely used in the ‘60s and beyond. If the “phen” part brings back the memory of lawsuits and long-term health effects, there’s a reason: originally, phentermine was part of a combo that also included fenfluramine and dexfenfluramine. The notorious “fen-phen” did, indeed, cause serious heart damage and was discontinued after creating a media stir in the ‘90s. Phentermine eventually came back onto the scene, making a solo re-entrance in 2012.

What’s the Science Behind Phentermine?

Phentermine works by causing a release of norepinephrine. This neurotransmitter is known for its role in the fight-or-flight response, which evolved to help us drop everything and jump into necessary action. (With a buffalo chasing us, who has time to finish carving that pineapple?!)

In addition to triggering norepinephrine, phentermine also boosts our dopamine levels. This neurotransmitter is part of the so-called “reward pathway” and is in charge of motivating us to do things that feel good. (So, in addition to getting the boost of alertness we feel from the norepinephrine surge, we also get a motivation kick and feel eager to run from that metaphorical buffalo.)

Is Phentermine Safe?

For those with lingering doubts about phentermine’s safety — yes, it is. Kind of. Needless to say, phentermine is not a “forever” solution and is only prescribed when the dangers of excessive weight outweigh the potential strain on our body if we use it for a longer period of time than recommended. 

That said, we should be vigilant and tell our doctor about anything else we’re taking in order to avoid potentially dangerous interactions. For example, phentermine doesn’t mix well with many antidepressants and shouldn’t be taken by anyone with a heart condition as it can increase blood pressure. Pregnant women and folks over the age of 65 should also avoid this medication. It can be habit forming because its stimulant properties and dopamine-boosting effect can have a mood-altering effect for some of us who are particularly sensitive to psychoactive substances.

Finally, phentermine works best if it’s combined with a diet and exercise program to create a solid foundation for sustainable weight loss. As much as some of us would like to have a “magic pill” to shed pounds for good, it simply doesn’t exist.

Can You Drink Alcohol While Taking Phentermine?

Drinking on phentermine is not a good idea for several reasons. Let’s dig deeper and find out why.

Heart Trouble 

Phentermine doesn’t just decrease our appetite — it also increases our heart rate and blood pressure. (Remember about norepinephrine and running from the buffalo? In addition to putting our hunger cues on hold, a situation that demands our energy in an instant also calls for a cardiovascular spike to give our muscles and sensory organs all the resources we’ve got)

At the same time, alcohol itself isn’t as heart-friendly as the media sometimes leads us to believe. (Many of the “heart benefits” in wine, for instance, come from antioxidants that are easily found in grapes or pomegranate — without the dangerous add-ons of booze.) In fact, alcohol can cause heart palpitations and sometimes lead to the so-called “holiday heart syndrome” if we overdo it. Alcohol also tends to lower our blood pressure at first due to vasodilation before leading to a rebound spike later on. (For more information, check out “How Does Alcohol Affect the Heart?”)

The combination of alcohol and phentermine can lead to dangerous cardiovascular side effects, such as blood pressure fluctuations and increased heart rate. Since both substances alone are hard on the heart, combining them ups the risk even more.

The Stimulant-Depressant Seesaw

Moreover, mixing stimulants (such as phentermine) and depressants (alcohol) can cause unpredictable cognitive effects. In addition to taxing our cardiovascular system, the combination can lead to neurological effects such as memory glitches, disruptions in normal thinking and decision-making processes, and increased drug-seeking behavior. (To learn more, take a look at “The Side Effects of Mixing Alcohol and Caffeine.”)

The Dehydration Dilemma

Both alcohol and phentermine can lead to dehydration. According to NIAAA, alcohol suppresses vasopressin, a hormone that tells the kidneys to hold on to fluids. The result? Those incessant trips to the bathroom throughout the evening (and night) and a nasty hangover headache the morning after. (For an in-depth look, check out “Breaking the Seal: Why Does Alcohol Make You Pee So Much?”)

Phentermine is known to cause dehydration and dry mouth as well, so combining it with alcohol can leave us feeling extra parched.

Phentermine and Alcohol: Long-Term Risks

Over time, combining phentermine with alcohol can lead to more serious problems.

Weight in Limbo: A Counterproductive Combo

Combining alcohol and phentermine is counterproductive in the long run. Why? If our goal is to lose weight, alcohol is not our friend. Let’s take a deeper look.

  • Filling up on empty calories. First and foremost, alcoholic drinks tend to be a diet disaster. One margarita packs about 168 calories, while a piña colada is a veritable diet disaster with as many as 526 calories.
  • Revving up hunger hormones. Alcohol stimulates ghrelin — the hunger hormone that drives us toward that late-night slice of pizza (or three). It also suppresses the satiety hormone, leptin — a double whammy, as far as our diet plans are concerned.
  • Hitting the metabolism brakes. Because the body sees alcohol as a poison, it prioritizes its metabolism above everything else. The result? The liver puts other metabolic processes on hold, making it more likely that anything else we eat will get stored as fat. This shift leads to an initial drop in blood sugar levels, followed by a rebound spike as the body struggles to process sugar. In the long term, heavy drinking can even lead to alcohol-related diabetes.

Want more information? Check out “The Link Between Alcohol and Unwanted Weight Gain.”

Potential for Dependence: Phentermine and Alcohol Misuse

Finally, there’s a slippery slope when relying on substances for mood regulation or weight loss, leading to potential dependence or misuse. Remember dopamine, the reward neurotransmitter? Both alcohol and phentermine boost dopamine levels in a way that leads to a higher surge of motivation and pleasure than our brain is naturally designed for. 

This is another reason why phentermine shouldn’t be used on a long-term basis: the brain gets used to a “free” boost of dopamine on demand and starts “demanding” more, sometimes with devastating effects such as dependence, overdose, and the possibility of transfer addictions. We’re likely to start using the substance that’s causing the dopamine rush just to feel normal, and we might even increase our dose over time. This potential for dependence is something to keep in mind when considering phentermine as a treatment option, especially if we have a history of substance misuse, including alcohol. It’s crucial to be honest with our healthcare provider about this part of our history to avoid serious problems down the road.

While both phentermine and alcohol alone can lead to dependence, combining the two ups our risk even more. With dopamine flooding our brain from two sources, it can be that much easier to get stuck in a dangerous cycle of potential addiction and misuse.

How Long Should I Wait To Drink After Taking Phentermine?

If drinking on phentermine isn’t recommended, when is it safe? For example, you might be wondering, “If I take phentermine in the morning, can I drink at night?” 

It’s not a good idea. 

Phentermine has a half life of about 20 hours, but stays in your system for as long as 4 days. So it’s better to wait at least a few days.

Tips for a Safe Alcohol and Weight Loss Journey

Tips for a Safe Alcohol and Weight Loss Journey

Finally, here are some tips to help you along the way.

  1. Steer clear of the combo. Avoid drinking while taking phentermine. In addition to preventing potentially dangerous effects, cutting back on booze will also help you on your weight loss journey!
  2. Always check with your doctor. Follow the advice of your physician about how to take phentermine and what other interactions to avoid. Make sure they have a full picture of everything you’re taking, including any supplements or herbal drugs. When it comes to phentermine, it might make a difference, so it’s always best to be as thorough as possible!
  3. Ask for help when you need to. If you’re having trouble with alcohol, phentermine, or the combination of both, don’t hesitate to ask for help. There are plenty of folks who’ve been in your shoes and are ready to help, as well as professionals who’ve seen it all before and know what to do. Even if you find yourself starting to misuse either substance, don’t be afraid to admit it — asking for help is a sign of strength!
  4. Don’t think of phentermine as a “forever” solution. While it might help in the short term when you most need it, phentermine isn’t “forever,” so don’t get too attached. The potential side effects and risk of dependency aren’t worth it in the long run, so stick with your doctor’s recommendations when it comes to the time limit of using the medication as part of your weight management plan.
  5. Nourish your body. If you can, work with a nutritionist to carve out a customized meal plan for your weight loss goals. If it’s not an option, use the many resources available online to create your plan. Make sure to include plenty of nutrient-rich fruits and vegetables, lean proteins, and omega-3 fatty acids. The goal is to lose weight slowly and consistently, creating sustainable habits.
  6. Watch your sugar intake. In addition to potentially derailing your weight loss efforts, sugar increases alcohol cravings. In the long run, lowering your sugar intake is a great overall step in a healthier direction.
  7. Stay active. And, of course, let’s not forget physical activity! These days there are plenty of options beyond riding the exercise bike at the gym or running laps around the track — unless that’s your thing! Don’t want to leave the house? No problem! There are lots of great exercise routines for every level on YouTube. Try Popsugar Fitness or Fitness Blender to start with — they have a bit of everything.
  8. Try mindfulness. Mindfulness can work wonders for both alcohol and food cravings alike, so it can be a great tool to take your journey to the next level.
  9. Get support. Finally, everything is easier with a great support team at your side, and the same is true for the alcohol and weight loss journeys alike!

With these tips, you can stay on track in your weight loss journey and make sure that alcohol doesn’t derail your efforts.

Summing Up

While changing our eating habits (with or without phentermine) and our alcohol habits alike can feel challenging, it’s important to keep the long-term goal in mind: you’re on the way to a happier and healthier version of yourself! There are bound to be ups and downs along the way, but it will be worth it. 

In the end, it’s all about perspective. Looking at weight loss (and alcohol reduction) as an active choice we’re making to improve our lives can make the road that much easier. As Linda Spangle writes in 100 Days of Weight Loss: The Secret to Being Successful on Any Diet Plan, “Starting today, instead of saying ‘I have to’ when discussing your actions or goals, substitute the words ‘I choose to’ … ‘I have to lose weight’ becomes ‘I choose to lose weight.’ Saying ‘I choose to’ puts you in charge and affirms that you want to see results.”

When it comes to losing weight, there are all types of solutions out there. And while it’s not for everyone, medication can help. Among the many options, phentermine (known by the brand name Adipex) is a favorite for some thanks to its powerful hunger-blocking cues. That muffin in the bakery shop window? No longer enticing. Extra helping of mashed potatoes at Thanksgiving? No thanks.

But what about that glass of wine? Can you drink on phentermine? What are the dangers of combining Adipex and alcohol? Let’s find out!

What Is Phentermine?

A glass of whiskey and pills

Phentermine acts like a sort of neurological amp, increasing the signals of fullness in the brain and dialing down the hunger cues. 

According to Drugbank.com, phentermine came onto the scene in 1959 as an anti-obesity drug and became widely used in the ‘60s and beyond. If the “phen” part brings back the memory of lawsuits and long-term health effects, there’s a reason: originally, phentermine was part of a combo that also included fenfluramine and dexfenfluramine. The notorious “fen-phen” did, indeed, cause serious heart damage and was discontinued after creating a media stir in the ‘90s. Phentermine eventually came back onto the scene, making a solo re-entrance in 2012.

What’s the Science Behind Phentermine?

Phentermine works by causing a release of norepinephrine. This neurotransmitter is known for its role in the fight-or-flight response, which evolved to help us drop everything and jump into necessary action. (With a buffalo chasing us, who has time to finish carving that pineapple?!)

In addition to triggering norepinephrine, phentermine also boosts our dopamine levels. This neurotransmitter is part of the so-called “reward pathway” and is in charge of motivating us to do things that feel good. (So, in addition to getting the boost of alertness we feel from the norepinephrine surge, we also get a motivation kick and feel eager to run from that metaphorical buffalo.)

Is Phentermine Safe?

For those with lingering doubts about phentermine’s safety — yes, it is. Kind of. Needless to say, phentermine is not a “forever” solution and is only prescribed when the dangers of excessive weight outweigh the potential strain on our body if we use it for a longer period of time than recommended. 

That said, we should be vigilant and tell our doctor about anything else we’re taking in order to avoid potentially dangerous interactions. For example, phentermine doesn’t mix well with many antidepressants and shouldn’t be taken by anyone with a heart condition as it can increase blood pressure. Pregnant women and folks over the age of 65 should also avoid this medication. It can be habit forming because its stimulant properties and dopamine-boosting effect can have a mood-altering effect for some of us who are particularly sensitive to psychoactive substances.

Finally, phentermine works best if it’s combined with a diet and exercise program to create a solid foundation for sustainable weight loss. As much as some of us would like to have a “magic pill” to shed pounds for good, it simply doesn’t exist.

Can You Drink Alcohol While Taking Phentermine?

Drinking on phentermine is not a good idea for several reasons. Let’s dig deeper and find out why.

Heart Trouble 

Phentermine doesn’t just decrease our appetite — it also increases our heart rate and blood pressure. (Remember about norepinephrine and running from the buffalo? In addition to putting our hunger cues on hold, a situation that demands our energy in an instant also calls for a cardiovascular spike to give our muscles and sensory organs all the resources we’ve got)

At the same time, alcohol itself isn’t as heart-friendly as the media sometimes leads us to believe. (Many of the “heart benefits” in wine, for instance, come from antioxidants that are easily found in grapes or pomegranate — without the dangerous add-ons of booze.) In fact, alcohol can cause heart palpitations and sometimes lead to the so-called “holiday heart syndrome” if we overdo it. Alcohol also tends to lower our blood pressure at first due to vasodilation before leading to a rebound spike later on. (For more information, check out “How Does Alcohol Affect the Heart?”)

The combination of alcohol and phentermine can lead to dangerous cardiovascular side effects, such as blood pressure fluctuations and increased heart rate. Since both substances alone are hard on the heart, combining them ups the risk even more.

The Stimulant-Depressant Seesaw

Moreover, mixing stimulants (such as phentermine) and depressants (alcohol) can cause unpredictable cognitive effects. In addition to taxing our cardiovascular system, the combination can lead to neurological effects such as memory glitches, disruptions in normal thinking and decision-making processes, and increased drug-seeking behavior. (To learn more, take a look at “The Side Effects of Mixing Alcohol and Caffeine.”)

The Dehydration Dilemma

Both alcohol and phentermine can lead to dehydration. According to NIAAA, alcohol suppresses vasopressin, a hormone that tells the kidneys to hold on to fluids. The result? Those incessant trips to the bathroom throughout the evening (and night) and a nasty hangover headache the morning after. (For an in-depth look, check out “Breaking the Seal: Why Does Alcohol Make You Pee So Much?”)

Phentermine is known to cause dehydration and dry mouth as well, so combining it with alcohol can leave us feeling extra parched.

Phentermine and Alcohol: Long-Term Risks

Over time, combining phentermine with alcohol can lead to more serious problems.

Weight in Limbo: A Counterproductive Combo

Combining alcohol and phentermine is counterproductive in the long run. Why? If our goal is to lose weight, alcohol is not our friend. Let’s take a deeper look.

  • Filling up on empty calories. First and foremost, alcoholic drinks tend to be a diet disaster. One margarita packs about 168 calories, while a piña colada is a veritable diet disaster with as many as 526 calories.
  • Revving up hunger hormones. Alcohol stimulates ghrelin — the hunger hormone that drives us toward that late-night slice of pizza (or three). It also suppresses the satiety hormone, leptin — a double whammy, as far as our diet plans are concerned.
  • Hitting the metabolism brakes. Because the body sees alcohol as a poison, it prioritizes its metabolism above everything else. The result? The liver puts other metabolic processes on hold, making it more likely that anything else we eat will get stored as fat. This shift leads to an initial drop in blood sugar levels, followed by a rebound spike as the body struggles to process sugar. In the long term, heavy drinking can even lead to alcohol-related diabetes.

Want more information? Check out “The Link Between Alcohol and Unwanted Weight Gain.”

Potential for Dependence: Phentermine and Alcohol Misuse

Finally, there’s a slippery slope when relying on substances for mood regulation or weight loss, leading to potential dependence or misuse. Remember dopamine, the reward neurotransmitter? Both alcohol and phentermine boost dopamine levels in a way that leads to a higher surge of motivation and pleasure than our brain is naturally designed for. 

This is another reason why phentermine shouldn’t be used on a long-term basis: the brain gets used to a “free” boost of dopamine on demand and starts “demanding” more, sometimes with devastating effects such as dependence, overdose, and the possibility of transfer addictions. We’re likely to start using the substance that’s causing the dopamine rush just to feel normal, and we might even increase our dose over time. This potential for dependence is something to keep in mind when considering phentermine as a treatment option, especially if we have a history of substance misuse, including alcohol. It’s crucial to be honest with our healthcare provider about this part of our history to avoid serious problems down the road.

While both phentermine and alcohol alone can lead to dependence, combining the two ups our risk even more. With dopamine flooding our brain from two sources, it can be that much easier to get stuck in a dangerous cycle of potential addiction and misuse.

How Long Should I Wait To Drink After Taking Phentermine?

If drinking on phentermine isn’t recommended, when is it safe? For example, you might be wondering, “If I take phentermine in the morning, can I drink at night?” 

It’s not a good idea. 

Phentermine has a half life of about 20 hours, but stays in your system for as long as 4 days. So it’s better to wait at least a few days.

Tips for a Safe Alcohol and Weight Loss Journey

Tips for a Safe Alcohol and Weight Loss Journey

Finally, here are some tips to help you along the way.

  1. Steer clear of the combo. Avoid drinking while taking phentermine. In addition to preventing potentially dangerous effects, cutting back on booze will also help you on your weight loss journey!
  2. Always check with your doctor. Follow the advice of your physician about how to take phentermine and what other interactions to avoid. Make sure they have a full picture of everything you’re taking, including any supplements or herbal drugs. When it comes to phentermine, it might make a difference, so it’s always best to be as thorough as possible!
  3. Ask for help when you need to. If you’re having trouble with alcohol, phentermine, or the combination of both, don’t hesitate to ask for help. There are plenty of folks who’ve been in your shoes and are ready to help, as well as professionals who’ve seen it all before and know what to do. Even if you find yourself starting to misuse either substance, don’t be afraid to admit it — asking for help is a sign of strength!
  4. Don’t think of phentermine as a “forever” solution. While it might help in the short term when you most need it, phentermine isn’t “forever,” so don’t get too attached. The potential side effects and risk of dependency aren’t worth it in the long run, so stick with your doctor’s recommendations when it comes to the time limit of using the medication as part of your weight management plan.
  5. Nourish your body. If you can, work with a nutritionist to carve out a customized meal plan for your weight loss goals. If it’s not an option, use the many resources available online to create your plan. Make sure to include plenty of nutrient-rich fruits and vegetables, lean proteins, and omega-3 fatty acids. The goal is to lose weight slowly and consistently, creating sustainable habits.
  6. Watch your sugar intake. In addition to potentially derailing your weight loss efforts, sugar increases alcohol cravings. In the long run, lowering your sugar intake is a great overall step in a healthier direction.
  7. Stay active. And, of course, let’s not forget physical activity! These days there are plenty of options beyond riding the exercise bike at the gym or running laps around the track — unless that’s your thing! Don’t want to leave the house? No problem! There are lots of great exercise routines for every level on YouTube. Try Popsugar Fitness or Fitness Blender to start with — they have a bit of everything.
  8. Try mindfulness. Mindfulness can work wonders for both alcohol and food cravings alike, so it can be a great tool to take your journey to the next level.
  9. Get support. Finally, everything is easier with a great support team at your side, and the same is true for the alcohol and weight loss journeys alike!

With these tips, you can stay on track in your weight loss journey and make sure that alcohol doesn’t derail your efforts.

Summing Up

While changing our eating habits (with or without phentermine) and our alcohol habits alike can feel challenging, it’s important to keep the long-term goal in mind: you’re on the way to a happier and healthier version of yourself! There are bound to be ups and downs along the way, but it will be worth it. 

In the end, it’s all about perspective. Looking at weight loss (and alcohol reduction) as an active choice we’re making to improve our lives can make the road that much easier. As Linda Spangle writes in 100 Days of Weight Loss: The Secret to Being Successful on Any Diet Plan, “Starting today, instead of saying ‘I have to’ when discussing your actions or goals, substitute the words ‘I choose to’ … ‘I have to lose weight’ becomes ‘I choose to lose weight.’ Saying ‘I choose to’ puts you in charge and affirms that you want to see results.”

Alcohol and Medications
2024-05-27 9:00
Alcohol and Medications
Alcohol’s Interaction With Phenylephrine
This is some text inside of a div block.

Feeling congested and reaching for something to help? Phenylephrine is an over-the-counter decongestant that can help, but should it be mixed with alcohol?

16 min read

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In the complex landscape of medication usage and lifestyle choices, understanding the interactions between substances is paramount for ensuring optimal health and well-being. Among these interactions, the interplay between alcohol consumption and certain medications has garnered significant attention due to its potential implications. One such medication of interest is phenylephrine, a commonly used decongestant found in various over-the-counter cold and flu remedies. Yet, while phenylephrine serves as a remedy for nasal congestion, its interaction with alcohol remains relatively understudied and poorly understood. 

Let’s unpack the intricate relationship between alcohol and phenylephrine, and shed some light on the potential risks and consequences that may arise from their co-administration. We’ll navigate through the science and learn about the implications behind this often-overlooked interaction. 

What Is Phenylephrine? 

A glass of alcohol and pills on a yellow background

Phenylephrine, also known by the brand name Sudafed PE, is in a class of medications called decongestants. Phenylephrine is an over-the-counter medicine used to relieve nasal discomfort from colds or allergies. It often has HCl added to it to increase the absorption (known as phenylephrine HCl), kind of the way vitamin D is added to milk to increase the absorption of calcium. 

The medication works by reducing swelling in the nose and relieving congestion, making it easier to breathe. Phenylephrine, however, is not to be confused with pseudoephedrine (Sudafed), which is sold behind the counter at pharmacies. Pseudoephedrine and phenylephrine are two different medications: phenylephrine (Sudafed PE) is a medication you can get over-the-counter without going to the pharmacy counter, while you have to go to the pharmacy counter with a valid ID to get pseudoephedrine (Sudafed). 

Phenylephrine has a chemical structure that resembles epinephrine (adrenaline), which is a hormone and neurotransmitter in the body. Specifically, phenylephrine targets a specific receptor of epinephrine called the alpha-adrenergic receptor, which is basically a fancy term for a receptor that regulates blood pressure. When activated, this receptor leads to vasoconstriction of blood vessels, which decreases blood flow to areas such as the skin, gastrointestinal system, kidneys, and brain. In the case of phenylephrine, the blood vessels in the nasal passages constrict, which decreases the swelling and congestion, giving us relief. 

As is normal when taking medications, there are side effects associated with phenylephrine. Let’s review some common ones:

  • High blood pressure
  • Headache
  • Dizziness
  • Lightheadedness
  • Nausea
  • Nervousness
  • Difficulty sleeping 
  • Upset stomach
  • Shakiness 

In some cases, as the medication wears off, there is a rebound effect, in which the congestion becomes worse than it was before taking the medication. Serious side effects are rare but do occur:

  • Severe allergic reaction
  • Irregular heartbeat
  • Difficulty breathing 
  • Uncontrolled shaking
  • Seizures

If you’re taking phenylephrine and experience any of these serious side effects, seek medical attention and stop taking the medication immediately. 

Phenylephrine and Alcohol: How Do They Interact?

Before we talk about the interactions of phenylephrine with alcohol, let’s look at how our body responds to alcohol.

Alcohol and Our Body

We know that alcohol affects many aspects of our body. It is also psychoactive, meaning it impacts our brain. Notoriously, alcohol is a depressant and slows down our central nervous system. One of the neurotransmitters affected by alcohol is epinephrine, which is increased during acute alcohol consumption. This increase in epinephrine can increase our heart rate and cause sleep disruption. 

Alcohol also impacts our blood and blood vessels. Alcohol acts as a vasodilator, meaning it expands our blood vessels throughout the body. Vasodilation can lead us to feeling warm, but the dilation also means our heart has to pump harder to push blood throughout our body, which decreases our blood pressure in the short term yet increases it in the long term. The lower blood pressure may cause an altered mental state, decrease the rate of breathing, and cause fainting or feelings of dizziness.

The heart is also affected by alcohol. When we start consuming alcohol, our heart rate can increase, and long-term alcohol use can weaken our heart and increase our chances of developing cardiovascular disease and having a stroke or heart attack.

So how does this change if we consume both alcohol and phenylephrine HCl at the same time? Let’s review the interaction between phenylephrine HCl and alcohol. 

Side Effects of Mixing Alcohol and Phenylephrine

Alcohol and Phenylephrine Interactions

The interaction between alcohol and phenylephrine can intensify the side effects of each. Here are some of the effects of this interaction on the body:

  • Increased blood pressure. The vasoconstriction effect of phenylephrine can increase our blood pressure. Large amounts of alcohol can temporarily raise our blood pressure, so consuming both can elevate our blood pressure to the point of getting hypertension. 
  • Rise in heart rate. Both alcohol and phenylephrine increase our heart rate. Consuming both at the same time can substantially raise our heart rate and lead to irregular heart rhythms or palpitations. 
  • Gastrointestinal problems. The gastrointestinal tract can be impacted by alcohol and phenylephrine. Phenylephrine can cause nausea or upset our stomach. Alcohol irritates the lining of the stomach, which can cause acid reflux, nausea, and stomach pain, so the combination of alcohol and phenylephrine could result in digestive disturbances and discomfort. 
  • Effects on the central nervous system. The interaction of phenylephrine and alcohol impacts our central nervous system. As we learned above, phenylephrine can make us feel more nervous and restless, and can induce insomnia. Alcohol can intensify these side effects while also causing us to feel drowsy and dizzy, as well as impairing our coordination. 

As we can see, drinking alcohol while taking phenylephrine can intensify our reaction to the medication and cause additional unpleasant side effects. These effects are more than just unpleasant, however — they are downright dangerous to our health. 

Risks of Drinking Alcohol While Taking Phenylephrine

Aside from intensifying the symptoms of both alcohol and phenylephrine, mixing the two substances comes with its own risks. Let’s review some of them: 

  • Extreme drowsiness. Drinking alcohol while taking phenylephrine can cause extreme depression of the central nervous system and lead to extreme drowsiness. 
  • Extreme dizziness or lightheadedness. Side effects of both alcohol and phenylephrine include feeling dizzy or lightheaded. Combining the two substances can compound this effect and result in extreme dizziness, which can ultimately lead to injury or harm. 
  • Cardiovascular effects. Alcohol and phenylephrine both cause increased heart rate, so the combination can wreak havoc on the heart and cause irregular heart rhythms or palpitations. 
  • Effects on the liver. Both phenylephrine and alcohol are processed by the liver, so combining them could put additional stress on it.
  • Increased risk of overdose. A regular dose of phenylephrine and a sip of alcohol will likely not lead to death. However, alcohol impairs our judgment and may lead to inadvertently taking higher doses of phenylephrine (or more alcohol) than recommended. Mixing alcohol and taking too much phenylephrine is dangerous and can lead to increased blood pressure, rapid heart rate, or unconsciousness. 

The risks associated with drinking alcohol while taking phenylephrine can be severe, especially if we’re taking more phenylephrine than we’re supposed to or drinking a lot while taking it. But how much is “a lot”? Can you drink on phenylephrine? 

Can You Drink Alcohol While Taking Phenylephrine?

Most medical professionals advise against drinking alcohol while taking phenylephrine, especially since we shouldn’t be taking phenylephrine long term. If we’re taking phenylephrine to ward off symptoms of the cold or flu, drinking alcohol can delay our recovery, as alcohol impairs our immune system. Avoiding alcohol while we’re sick is the best way to recover more quickly. 

Having one drink while taking phenylephrine will likely not end in immediate harm. Nevertheless, alcohol is still toxic to the body, and we should consult a medical professional before drinking while on phenylephrine.

Let’s say we recovered from our cold and are ready to have alcohol again. You may be wondering how long after taking phenylephrine you can drink alcohol. The half-life of phenylephrine is between 2 and 3 hours but will take about 5 to 6 hours to be eliminated completely from the body. It’s best to wait between 12 to 24 hours after taking your last dose of phenylephrine if you plan to start drinking alcohol again. 

Alternatives to Alcohol When Taking Phenylephrine

We’ve learned that when we have a cold or are fighting off seasonal allergies with phenylephrine, it’s best to avoid alcohol. That’s true if we’re sick in general. So, let’s explore some alternatives to alcohol that we can indulge in.

  • Non-alcoholic beverages. Alcohol-free cocktails or non-alcoholic beers are great alternatives to alcohol when we want to relax or socialize with a drink. (For some fun recipes, check out our blog “Alcohol-Free Drinks: 10 DIY Mocktail Recipes”).
  • Cooking or baking. Trying out some new recipes or baking a sweet treat to share with friends or family can be a fun alternative activity to drinking alcohol. 
  • Outdoor activities. Head to the outdoors for a hike or bike ride. Being outside and exercising helps to reduce stress and anxiety.
  • Movie or game night. Invite friends or family for some alcohol-free fun with your favorite movie or to enjoy a little healthy competition at a game night. 

This nonexhaustive list presents just a few of the many alcohol-free alternatives there are to enjoy while taking phenylephrine — or if you’re simply looking to quit or cut back on alcohol.

Key Takeaways

Mixing phenylephrine and alcohol can result in increased side effects of both substances. Although drinking alcohol while on phenylephrine will likely not end in death, it’s still hazardous to your health and not recommended.

In the complex landscape of medication usage and lifestyle choices, understanding the interactions between substances is paramount for ensuring optimal health and well-being. Among these interactions, the interplay between alcohol consumption and certain medications has garnered significant attention due to its potential implications. One such medication of interest is phenylephrine, a commonly used decongestant found in various over-the-counter cold and flu remedies. Yet, while phenylephrine serves as a remedy for nasal congestion, its interaction with alcohol remains relatively understudied and poorly understood. 

Let’s unpack the intricate relationship between alcohol and phenylephrine, and shed some light on the potential risks and consequences that may arise from their co-administration. We’ll navigate through the science and learn about the implications behind this often-overlooked interaction. 

What Is Phenylephrine? 

A glass of alcohol and pills on a yellow background

Phenylephrine, also known by the brand name Sudafed PE, is in a class of medications called decongestants. Phenylephrine is an over-the-counter medicine used to relieve nasal discomfort from colds or allergies. It often has HCl added to it to increase the absorption (known as phenylephrine HCl), kind of the way vitamin D is added to milk to increase the absorption of calcium. 

The medication works by reducing swelling in the nose and relieving congestion, making it easier to breathe. Phenylephrine, however, is not to be confused with pseudoephedrine (Sudafed), which is sold behind the counter at pharmacies. Pseudoephedrine and phenylephrine are two different medications: phenylephrine (Sudafed PE) is a medication you can get over-the-counter without going to the pharmacy counter, while you have to go to the pharmacy counter with a valid ID to get pseudoephedrine (Sudafed). 

Phenylephrine has a chemical structure that resembles epinephrine (adrenaline), which is a hormone and neurotransmitter in the body. Specifically, phenylephrine targets a specific receptor of epinephrine called the alpha-adrenergic receptor, which is basically a fancy term for a receptor that regulates blood pressure. When activated, this receptor leads to vasoconstriction of blood vessels, which decreases blood flow to areas such as the skin, gastrointestinal system, kidneys, and brain. In the case of phenylephrine, the blood vessels in the nasal passages constrict, which decreases the swelling and congestion, giving us relief. 

As is normal when taking medications, there are side effects associated with phenylephrine. Let’s review some common ones:

  • High blood pressure
  • Headache
  • Dizziness
  • Lightheadedness
  • Nausea
  • Nervousness
  • Difficulty sleeping 
  • Upset stomach
  • Shakiness 

In some cases, as the medication wears off, there is a rebound effect, in which the congestion becomes worse than it was before taking the medication. Serious side effects are rare but do occur:

  • Severe allergic reaction
  • Irregular heartbeat
  • Difficulty breathing 
  • Uncontrolled shaking
  • Seizures

If you’re taking phenylephrine and experience any of these serious side effects, seek medical attention and stop taking the medication immediately. 

Phenylephrine and Alcohol: How Do They Interact?

Before we talk about the interactions of phenylephrine with alcohol, let’s look at how our body responds to alcohol.

Alcohol and Our Body

We know that alcohol affects many aspects of our body. It is also psychoactive, meaning it impacts our brain. Notoriously, alcohol is a depressant and slows down our central nervous system. One of the neurotransmitters affected by alcohol is epinephrine, which is increased during acute alcohol consumption. This increase in epinephrine can increase our heart rate and cause sleep disruption. 

Alcohol also impacts our blood and blood vessels. Alcohol acts as a vasodilator, meaning it expands our blood vessels throughout the body. Vasodilation can lead us to feeling warm, but the dilation also means our heart has to pump harder to push blood throughout our body, which decreases our blood pressure in the short term yet increases it in the long term. The lower blood pressure may cause an altered mental state, decrease the rate of breathing, and cause fainting or feelings of dizziness.

The heart is also affected by alcohol. When we start consuming alcohol, our heart rate can increase, and long-term alcohol use can weaken our heart and increase our chances of developing cardiovascular disease and having a stroke or heart attack.

So how does this change if we consume both alcohol and phenylephrine HCl at the same time? Let’s review the interaction between phenylephrine HCl and alcohol. 

Side Effects of Mixing Alcohol and Phenylephrine

Alcohol and Phenylephrine Interactions

The interaction between alcohol and phenylephrine can intensify the side effects of each. Here are some of the effects of this interaction on the body:

  • Increased blood pressure. The vasoconstriction effect of phenylephrine can increase our blood pressure. Large amounts of alcohol can temporarily raise our blood pressure, so consuming both can elevate our blood pressure to the point of getting hypertension. 
  • Rise in heart rate. Both alcohol and phenylephrine increase our heart rate. Consuming both at the same time can substantially raise our heart rate and lead to irregular heart rhythms or palpitations. 
  • Gastrointestinal problems. The gastrointestinal tract can be impacted by alcohol and phenylephrine. Phenylephrine can cause nausea or upset our stomach. Alcohol irritates the lining of the stomach, which can cause acid reflux, nausea, and stomach pain, so the combination of alcohol and phenylephrine could result in digestive disturbances and discomfort. 
  • Effects on the central nervous system. The interaction of phenylephrine and alcohol impacts our central nervous system. As we learned above, phenylephrine can make us feel more nervous and restless, and can induce insomnia. Alcohol can intensify these side effects while also causing us to feel drowsy and dizzy, as well as impairing our coordination. 

As we can see, drinking alcohol while taking phenylephrine can intensify our reaction to the medication and cause additional unpleasant side effects. These effects are more than just unpleasant, however — they are downright dangerous to our health. 

Risks of Drinking Alcohol While Taking Phenylephrine

Aside from intensifying the symptoms of both alcohol and phenylephrine, mixing the two substances comes with its own risks. Let’s review some of them: 

  • Extreme drowsiness. Drinking alcohol while taking phenylephrine can cause extreme depression of the central nervous system and lead to extreme drowsiness. 
  • Extreme dizziness or lightheadedness. Side effects of both alcohol and phenylephrine include feeling dizzy or lightheaded. Combining the two substances can compound this effect and result in extreme dizziness, which can ultimately lead to injury or harm. 
  • Cardiovascular effects. Alcohol and phenylephrine both cause increased heart rate, so the combination can wreak havoc on the heart and cause irregular heart rhythms or palpitations. 
  • Effects on the liver. Both phenylephrine and alcohol are processed by the liver, so combining them could put additional stress on it.
  • Increased risk of overdose. A regular dose of phenylephrine and a sip of alcohol will likely not lead to death. However, alcohol impairs our judgment and may lead to inadvertently taking higher doses of phenylephrine (or more alcohol) than recommended. Mixing alcohol and taking too much phenylephrine is dangerous and can lead to increased blood pressure, rapid heart rate, or unconsciousness. 

The risks associated with drinking alcohol while taking phenylephrine can be severe, especially if we’re taking more phenylephrine than we’re supposed to or drinking a lot while taking it. But how much is “a lot”? Can you drink on phenylephrine? 

Can You Drink Alcohol While Taking Phenylephrine?

Most medical professionals advise against drinking alcohol while taking phenylephrine, especially since we shouldn’t be taking phenylephrine long term. If we’re taking phenylephrine to ward off symptoms of the cold or flu, drinking alcohol can delay our recovery, as alcohol impairs our immune system. Avoiding alcohol while we’re sick is the best way to recover more quickly. 

Having one drink while taking phenylephrine will likely not end in immediate harm. Nevertheless, alcohol is still toxic to the body, and we should consult a medical professional before drinking while on phenylephrine.

Let’s say we recovered from our cold and are ready to have alcohol again. You may be wondering how long after taking phenylephrine you can drink alcohol. The half-life of phenylephrine is between 2 and 3 hours but will take about 5 to 6 hours to be eliminated completely from the body. It’s best to wait between 12 to 24 hours after taking your last dose of phenylephrine if you plan to start drinking alcohol again. 

Alternatives to Alcohol When Taking Phenylephrine

We’ve learned that when we have a cold or are fighting off seasonal allergies with phenylephrine, it’s best to avoid alcohol. That’s true if we’re sick in general. So, let’s explore some alternatives to alcohol that we can indulge in.

  • Non-alcoholic beverages. Alcohol-free cocktails or non-alcoholic beers are great alternatives to alcohol when we want to relax or socialize with a drink. (For some fun recipes, check out our blog “Alcohol-Free Drinks: 10 DIY Mocktail Recipes”).
  • Cooking or baking. Trying out some new recipes or baking a sweet treat to share with friends or family can be a fun alternative activity to drinking alcohol. 
  • Outdoor activities. Head to the outdoors for a hike or bike ride. Being outside and exercising helps to reduce stress and anxiety.
  • Movie or game night. Invite friends or family for some alcohol-free fun with your favorite movie or to enjoy a little healthy competition at a game night. 

This nonexhaustive list presents just a few of the many alcohol-free alternatives there are to enjoy while taking phenylephrine — or if you’re simply looking to quit or cut back on alcohol.

Key Takeaways

Mixing phenylephrine and alcohol can result in increased side effects of both substances. Although drinking alcohol while on phenylephrine will likely not end in death, it’s still hazardous to your health and not recommended.

Alcohol and Medications
2024-05-07 9:00
Alcohol and Medications
Can You Drink Alcohol While Taking Keppra?
This is some text inside of a div block.

Keppra is an anti-epileptic medication used to treat seizures in people with epilepsy. Check out our latest blog for more information about Keppra’s interactions with alcohol.

16 min read

Ready To Give Your Brain Some Love? Quit or Cut Back on Alcohol With Reframe!

Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!

The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.

You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.

Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol. 

And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).

The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today! 

Read Full Article  →

Having a seizure can be an unpleasant experience, especially for those with epilepsy. Keppra (known by the generic name levetiracetam) is commonly prescribed to treat seizures in epilepsy patients. But what about mixing Keppra and alcohol? How does Keppra affect us, and can we drink alcohol while taking it? Let’s learn more about levetiracetam and alcohol, and what happens if we mix the two.

Keppra may be prescribed to control various types of seizures, but it is not a cure for epilepsy. Therefore, most patients who are prescribed Keppra need to be on it for a long time and require a doctor’s supervision when they stop taking it.

What Is Keppra and How Does it Work?

A woman holding pills and a glass of wine

Keppra is part of a class of medications known as “anticonvulsants,” that are used to treat seizures in people with epilepsy. The exact dosage depends on the patient but is typically taken daily. The amount of time someone stays on Keppra also varies depending on the patient, but some take it for up to five years. If you stop taking it, it must be done slowly and under the guidance of a doctor.

There are few Keppra uses beyond treating epilepsy, but it is sometimes used to treat seizures during alcohol withdrawal.

But what causes a seizure? Seizures are caused by too much “excitatory” activity in the brain. Anticonvulsant drugs, in general, alter electrical activity in the brain’s neurons and increase GABA, which calms this excitatory activity. Keppra works by decreasing the excess excitation in the brain and increasing inhibition. 

Side Effects of Keppra

The side effects of Keppra vary depending on the type of seizure being treated, but they can all be pretty worrisome:

  • Aggression
  • Anxiety
  • Personality changes and mood swings
  • Drowsiness
  • Delusions
  • Uncontrolled anger (known as “Keppra rage”)
  • Feeling disconnected from reality
  • Depression and suicidal thoughts

If you are experiencing thoughts of suicide, please seek medical attention. In the United States, you can reach your local crisis hotline by dialing 988. Click here for a list of mental crisis phone numbers by country

Is There an Interaction Between Keppra and Alcohol?

So, we know what Keppra is and what it does, but what does the Keppra alcohol interaction do to us? Well, not only does it affect our brain, but it affects other parts of our body as well. Let’s examine each of these in more detail.

Effects on Our Brain

Remember those nasty side effects of Keppra we talked about earlier? Well, bringing alcohol into the mix can exacerbate them. Since alcohol affects the brain, it can interfere with the work that Keppra is trying to do to treat the brain. The combination can cause a range of reactions from increased drowsiness to extreme sedation to mood swings to depression to suicidal thoughts.

The use of alcohol on its own can induce a seizure in some people with epilepsy. Combine that with making Keppra less effective, and you have a recipe for trouble.

The bottom line is that it’s best to avoid alcohol while taking Keppra, and definitely not to have more than 14 units of alcohol per week if you do plan to drink.

Even if we’re not taking Keppra, alcohol is bad news for those of us with epilepsy. Consuming more than two drinks per day puts epileptics at risk for seizures, so it’s best to avoid it if you have epilepsy. Alcohol is actually one of the most common triggers for epileptic seizures.

While most alcohol-related seizures occur as a result of withdrawal, heavy alcohol use can increase the risk of developing seizures in people who don’t have epilepsy. One study shows that a person’s seizure threshold — meaning how likely the brain is to have a seizure — increases after heavy alcohol use (particularly three drinks or more per day).

Effects on the Central Nervous System

Both alcohol and Keppra depress the central nervous system (CNS), slowing down the body’s functions. When we combine multiple substances that depress the central nervous system, we set ourselves up for a major imbalance of chemicals in the brain that can lead to severe sedation and even a coma. Not only that, combining alcohol and Keppra can heighten each other’s side effects of dizziness or fatigue, both of which are symptoms of CNS depression. 

Effects on Our Liver

We know alcohol damages the liver, but what about Keppra? As it turns out, Keppra has been linked to liver damage in some rare cases. While the research on this is minimal, it’s not worth the risk of further damaging the liver by adding alcohol to the mix.

Effects on Our Kidneys

Alcohol damages the kidneys by disrupting the hormones that regulate kidney function. Keppra is mainly processed and eliminated by the kidneys, so any damage to the kidneys from alcohol means that the kidneys can’t eliminate as much Keppra from the body. This means our dosage of Keppra needs to be reduced, which gives us less protection against seizures.

Effects on Our Mood

We’ve talked about the side effects of Keppra and how mood swings and depression are among those. But did you know that alcohol also has a negative effect on our mood? While that first sip may make us feel relaxed and ready to socialize, alcohol can conjure up a whole lot of negative emotions. Once the alcohol has left our body, we experience a sudden decrease in GABA, the calming inhibitory neurotransmitter, which leads to feelings of restlessness, anxiety, and irritability (For more information, check out our blog “Why Does Alcohol Make Me Moody the Next Day?”). If we combine these negative effects of alcohol with the side effects of Keppra, we have a much higher risk of severe mood swings and suicidal thoughts.

How Long After Stopping Keppra Can I Drink Alcohol?

Say we’re ready to get off Keppra and have been slowly doing so under the supervision of our doctor, now what? How long do we need to wait if we plan to consume alcohol? It can take up to 44 hours for Keppra to be completely out of our system after the last dose, so it’s best to wait at least that long before consuming any alcohol. But just because our seizures are under control doesn’t mean we’re in the clear. Keep in mind that consuming more than two drinks per day puts epileptics at risk for seizures, so it’s best for anyone who has epilepsy to avoid alcohol. And since there is limited research on Keppra, and the dosage varies so widely among patients, it’s best to talk to your doctor before consuming any alcohol.

Tips for Taking Keppra Safely — Without Alcohol

Tips To Stay Safe While Taking Keppra

Mixing alcohol with Keppra has some pretty nasty effects, but luckily there are plenty of things we can do to stay safe and prioritize our health. Keep these tips in mind:

  1. Know your triggers. Flashing lights aren’t the only thing to watch out for when avoiding seizures. Alcohol is a common trigger for epileptic seizures, and so is lack of sleep. And since alcohol contributes to a lack of sleep, this effect is compounded. Not only that, hormone changes and dehydration are also linked to epileptic seizures, which alcohol also contributes to.
  2. Stick to non-alcoholic beverages during treatment. Mocktails are a safe alternative to alcohol as long as they are truly alcohol-free. Keep in mind that non-alcoholic beer still contains trace amounts of alcohol and may still interact with certain medications, so be sure to talk to your healthcare provider if you plan to drink it while taking Keppra.
  3. Seek support. Support from loved ones or a community can help tremendously during any treatment. We can also talk to our loved ones about our condition so we won’t feel put on the spot during activities that involve drinking.
  4. Practice brain-healthy activities. Activities such as yoga and meditation as well as practicing mindfulness can calm the brain, so instead of turning to that evening glass of wine to calm down, we can calm both our body and our mind in a healthy way. Studies show that meditation and practicing mindfulness can work wonders for epilepsy patients, so it won’t hurt to add some yoga or meditation to your daily routine (For some ideas for mindful activities to try out, check out our blog “11 Mindfulness Exercises and Activities for Adults”).

All of these activities will lead you down the road to better health and safety while taking Keppra.

A Bit of Brainy Inspiration

Undergoing treatment for epilepsy can be a lot to think about, and since the brain is such a complex piece of equipment, there are still many mechanisms to its interactions that we don’t fully understand (ironic, isn’t it, since we use our brains to study other brains.) Keppra in particular is understudied, which is even more reason to leave the booze behind when taking it. And just remember that we’re not only doing our brains a favor by cutting out the booze, we’re opening up our lives to a whole world of happier, healthier habits.

Having a seizure can be an unpleasant experience, especially for those with epilepsy. Keppra (known by the generic name levetiracetam) is commonly prescribed to treat seizures in epilepsy patients. But what about mixing Keppra and alcohol? How does Keppra affect us, and can we drink alcohol while taking it? Let’s learn more about levetiracetam and alcohol, and what happens if we mix the two.

Keppra may be prescribed to control various types of seizures, but it is not a cure for epilepsy. Therefore, most patients who are prescribed Keppra need to be on it for a long time and require a doctor’s supervision when they stop taking it.

What Is Keppra and How Does it Work?

A woman holding pills and a glass of wine

Keppra is part of a class of medications known as “anticonvulsants,” that are used to treat seizures in people with epilepsy. The exact dosage depends on the patient but is typically taken daily. The amount of time someone stays on Keppra also varies depending on the patient, but some take it for up to five years. If you stop taking it, it must be done slowly and under the guidance of a doctor.

There are few Keppra uses beyond treating epilepsy, but it is sometimes used to treat seizures during alcohol withdrawal.

But what causes a seizure? Seizures are caused by too much “excitatory” activity in the brain. Anticonvulsant drugs, in general, alter electrical activity in the brain’s neurons and increase GABA, which calms this excitatory activity. Keppra works by decreasing the excess excitation in the brain and increasing inhibition. 

Side Effects of Keppra

The side effects of Keppra vary depending on the type of seizure being treated, but they can all be pretty worrisome:

  • Aggression
  • Anxiety
  • Personality changes and mood swings
  • Drowsiness
  • Delusions
  • Uncontrolled anger (known as “Keppra rage”)
  • Feeling disconnected from reality
  • Depression and suicidal thoughts

If you are experiencing thoughts of suicide, please seek medical attention. In the United States, you can reach your local crisis hotline by dialing 988. Click here for a list of mental crisis phone numbers by country

Is There an Interaction Between Keppra and Alcohol?

So, we know what Keppra is and what it does, but what does the Keppra alcohol interaction do to us? Well, not only does it affect our brain, but it affects other parts of our body as well. Let’s examine each of these in more detail.

Effects on Our Brain

Remember those nasty side effects of Keppra we talked about earlier? Well, bringing alcohol into the mix can exacerbate them. Since alcohol affects the brain, it can interfere with the work that Keppra is trying to do to treat the brain. The combination can cause a range of reactions from increased drowsiness to extreme sedation to mood swings to depression to suicidal thoughts.

The use of alcohol on its own can induce a seizure in some people with epilepsy. Combine that with making Keppra less effective, and you have a recipe for trouble.

The bottom line is that it’s best to avoid alcohol while taking Keppra, and definitely not to have more than 14 units of alcohol per week if you do plan to drink.

Even if we’re not taking Keppra, alcohol is bad news for those of us with epilepsy. Consuming more than two drinks per day puts epileptics at risk for seizures, so it’s best to avoid it if you have epilepsy. Alcohol is actually one of the most common triggers for epileptic seizures.

While most alcohol-related seizures occur as a result of withdrawal, heavy alcohol use can increase the risk of developing seizures in people who don’t have epilepsy. One study shows that a person’s seizure threshold — meaning how likely the brain is to have a seizure — increases after heavy alcohol use (particularly three drinks or more per day).

Effects on the Central Nervous System

Both alcohol and Keppra depress the central nervous system (CNS), slowing down the body’s functions. When we combine multiple substances that depress the central nervous system, we set ourselves up for a major imbalance of chemicals in the brain that can lead to severe sedation and even a coma. Not only that, combining alcohol and Keppra can heighten each other’s side effects of dizziness or fatigue, both of which are symptoms of CNS depression. 

Effects on Our Liver

We know alcohol damages the liver, but what about Keppra? As it turns out, Keppra has been linked to liver damage in some rare cases. While the research on this is minimal, it’s not worth the risk of further damaging the liver by adding alcohol to the mix.

Effects on Our Kidneys

Alcohol damages the kidneys by disrupting the hormones that regulate kidney function. Keppra is mainly processed and eliminated by the kidneys, so any damage to the kidneys from alcohol means that the kidneys can’t eliminate as much Keppra from the body. This means our dosage of Keppra needs to be reduced, which gives us less protection against seizures.

Effects on Our Mood

We’ve talked about the side effects of Keppra and how mood swings and depression are among those. But did you know that alcohol also has a negative effect on our mood? While that first sip may make us feel relaxed and ready to socialize, alcohol can conjure up a whole lot of negative emotions. Once the alcohol has left our body, we experience a sudden decrease in GABA, the calming inhibitory neurotransmitter, which leads to feelings of restlessness, anxiety, and irritability (For more information, check out our blog “Why Does Alcohol Make Me Moody the Next Day?”). If we combine these negative effects of alcohol with the side effects of Keppra, we have a much higher risk of severe mood swings and suicidal thoughts.

How Long After Stopping Keppra Can I Drink Alcohol?

Say we’re ready to get off Keppra and have been slowly doing so under the supervision of our doctor, now what? How long do we need to wait if we plan to consume alcohol? It can take up to 44 hours for Keppra to be completely out of our system after the last dose, so it’s best to wait at least that long before consuming any alcohol. But just because our seizures are under control doesn’t mean we’re in the clear. Keep in mind that consuming more than two drinks per day puts epileptics at risk for seizures, so it’s best for anyone who has epilepsy to avoid alcohol. And since there is limited research on Keppra, and the dosage varies so widely among patients, it’s best to talk to your doctor before consuming any alcohol.

Tips for Taking Keppra Safely — Without Alcohol

Tips To Stay Safe While Taking Keppra

Mixing alcohol with Keppra has some pretty nasty effects, but luckily there are plenty of things we can do to stay safe and prioritize our health. Keep these tips in mind:

  1. Know your triggers. Flashing lights aren’t the only thing to watch out for when avoiding seizures. Alcohol is a common trigger for epileptic seizures, and so is lack of sleep. And since alcohol contributes to a lack of sleep, this effect is compounded. Not only that, hormone changes and dehydration are also linked to epileptic seizures, which alcohol also contributes to.
  2. Stick to non-alcoholic beverages during treatment. Mocktails are a safe alternative to alcohol as long as they are truly alcohol-free. Keep in mind that non-alcoholic beer still contains trace amounts of alcohol and may still interact with certain medications, so be sure to talk to your healthcare provider if you plan to drink it while taking Keppra.
  3. Seek support. Support from loved ones or a community can help tremendously during any treatment. We can also talk to our loved ones about our condition so we won’t feel put on the spot during activities that involve drinking.
  4. Practice brain-healthy activities. Activities such as yoga and meditation as well as practicing mindfulness can calm the brain, so instead of turning to that evening glass of wine to calm down, we can calm both our body and our mind in a healthy way. Studies show that meditation and practicing mindfulness can work wonders for epilepsy patients, so it won’t hurt to add some yoga or meditation to your daily routine (For some ideas for mindful activities to try out, check out our blog “11 Mindfulness Exercises and Activities for Adults”).

All of these activities will lead you down the road to better health and safety while taking Keppra.

A Bit of Brainy Inspiration

Undergoing treatment for epilepsy can be a lot to think about, and since the brain is such a complex piece of equipment, there are still many mechanisms to its interactions that we don’t fully understand (ironic, isn’t it, since we use our brains to study other brains.) Keppra in particular is understudied, which is even more reason to leave the booze behind when taking it. And just remember that we’re not only doing our brains a favor by cutting out the booze, we’re opening up our lives to a whole world of happier, healthier habits.

Alcohol and Medications
2024-05-06 9:00
Alcohol and Medications
Beta-Blockers and Alcohol: Interactions and Risks
This is some text inside of a div block.

Alcohol + Beta-blockers = a risky pair ⚠️ Mixing these can mess with your heart rate and blood pressure, leading to serious health risks. Learn more on today’s blog.

13 min read

On Beta-Blockers? Cutback or Quit Alcohol With Reframe!

Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!

The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.

You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.

Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol. 

And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).

The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today! 

Read Full Article  →

Picture this: you're enjoying a night out with friends, ready to unwind and let loose, but suddenly you remember you just started a new medication this week — propranolol. Is it still safe to throw back a few drinks?

In this post, you will learn how beta-blockers like propranolol work, how alcohol affects our cardiovascular health, how alcohol interacts with beta-blockers, and how to manage your relationship with alcohol while on beta-blockers. 

What Are Beta-Blockers?

a person pouring pills from a bottle into their other hand

Beta-blockers are a class of medication typically used to treat heart- and circulatory-related problems. However, because beta receptors are found in multiple locations throughout the body, beta-blockers can treat a wide range of problems: 

  • Heart arrhythmias
  • Chest pain (angina) 
  • Coronary artery disease
  • Heart attack or congestive heart failure
  • High blood pressure (hypertension)
  • Enlarged heart
  • Migraines
  • Glaucoma
  • Overactive thyroid (hyperthyroidism) 
  • Anxiety 

These are just some conditions that beta-blockers are used for. But how do beta-blockers work? 

How Do Beta-Blockers Work?

Beta-blockers work by blocking certain hormones from activating beta receptors, also called adrenergic receptors. There are three types of beta receptors: 

  • Beta-1 receptors. When activated, these receptors increase cardiac activity and activate the release of an enzyme found in our kidneys called renin. 
  • Beta-2 receptors. When activated, these relax our airways and lower blood pressure, but they may also cause muscle tremors.
  • Beta-3 receptors. When these are activated, they cause fat cells to break down, increase bladder capacity, and cause tremors. 

Since there are different beta receptors, beta-blockers often selectively target a specific type of beta receptor. Generally, beta-blockers fall into two categories based on whether they are cardioselective (beta-1 receptors) or not. Common cardioselective beta-blockers are atenolol, betaxolol, bisoprolol, esmolol, acebutolol, metoprolol, and nebivolol. Popular nonselective beta-blockers include propranolol, nadolol, pindolol, labetalol, trandate, penbutolol, or sotalol. 

Someone struggling with high blood pressure or anxiety, for example, might be prescribed propranolol, which blocks adrenaline (a stress hormone) from beta-1 receptors. The result is a decreased heart rate, making it easier for the heart to pump blood throughout your body.

While they are usually short-lived and mild, there are some side effects to be aware of: 

  • Feeling tired, dizzy, or lightheaded
  • Having cold fingers or toes 
  • Weight gain
  • Depression
  • Shortness of breath 
  • Difficulties sleeping or having nightmares

Not everyone will experience all the side effects associated with beta-blockers, but it’s good to be aware of them in case you do.

Alcohol’s Effects on the Heart

As we drink alcohol, it gets absorbed through the small intestines to the bloodstream. Once in our bloodstream, it has multiple effects on our cardiovascular system. Let’s take a look at how alcohol consumption affects our heart in the short and long term. 

In the short term, alcohol increases our heart rate and blood pressure and potentially leads to heart palpitations. Heart palpitations are a feeling of having a fast-beating, fluttering, or pounding heart that can feel worrisome, but they are harmless most of the time. After we are done drinking and the alcohol leaves our bloodstream, our blood pressure and heart rate go back to normal. 

When we drink heavily for a long time, we can damage our heart. Heavy drinking can result in tachycardia (when the heart beats too fast), high blood pressure, weakened heart muscles, irregular heartbeat, atrial fibrillation (the heart quivers instead of beats), or an enlarged heart. Many of these long-term effects on the heart can increase the chances of having a heart attack or stroke. Research shows us that heavy drinkers have more strokes and a greater chance of dying from strokes.

Side Effects of Mixing Alcohol and Beta-Blockers

Alcohol and Beta-Blockers

Interactions

Alcohol’s impact on beta-blockers ranges based on the type of beta-blocker. Alcohol and beta-blockers can be a dangerous mix. Alcohol may decrease the effectiveness of beta-blockers by changing how they are released into the body or the speed at which the body metabolizes them. Mixing metoprolol and alcohol, for example, can speed up the release of the drug into our body and decrease its effectiveness. On the other hand, mixing propranolol and alcohol or flecainide and alcohol might not reduce the effectiveness of the drugs but may enhance the effects of alcohol. 

Side Effects

In general, drinking while on beta-blockers can enhance the side effects associated with both alcohol and beta-blockers. Let’s review some side effects associated with drinking alcohol while on beta-blockers: 

  • Excessive sedation and dizziness. Alcohol use and beta-blockers can both cause dizziness and drowsiness. Combining the two can intensify the feelings and lead to more accidents and injuries. 
  • Hypotension. Hypotension is when our blood pressure gets below the normal level. When our blood pressure is too low, we don’t get enough blood to essential areas in our body such as the heart and brain. Beta-blockers and alcohol can lower blood pressure, so having them both can excessively lower our blood pressure and lead to fainting, dizziness, or shock. 
  • Tachycardia. Tachycardia is when our heart rate exceeds 100 beats per minute. Beta-blockers tend to slow our heart rate, and alcohol has the opposite effect. These conflicting actions can lead to tachycardia, irregular heartbeat, or heart palpitations. 
  • Worsened heart conditions. If we are on beta-blockers, we are likely prescribed them to manage issues of the heart. Alcohol consumption can make our heart conditions worse and interferes with the progress we made with the medication. 
  • Liver function. Alcohol is toxic to our liver and can cause long-term damage. Beta-blockers can also negatively impact our liver function, so mixing the two can compound the risks. 

If the associated risks haven’t deterred you, the question remains: can you drink on beta-blockers? While it is likely not life-threatening, most physicians won’t recommend it; however, it will largely depend on the type of beta-blocker in question. If we are using it for heart-related problems, alcohol probably isn’t safe. It’s always best to seek medical advice before we drink alcohol while on beta-blockers. 

Managing Our Relationship With Alcohol While on Beta-Blockers

Even if we know the associated risks, it may be hard to quit our current drinking habits. Let’s go through some tips on how we can have a healthy relationship with alcohol while we are on beta-blockers: 

  • Drink in moderation. Having one or two drinks while on beta-blockers is likely not life-threatening. However, make sure you consult with your prescribing physician before you drink any alcohol. 
  • Don’t skip your beta-blocker! You should never skip a dose of your beta-blocker to drink alcohol. Abruptly stopping beta-blockers can result in a thyroid storm, heart attack, anxiety, or hypertension. A thyroid storm can increase your heart rate, blood pressure, and body temperature to abnormally high levels and be life-threatening. 
  • Skip the alcohol. Instead of drinking alcohol, try alcohol-free alternatives such as mocktails or non-alcoholic beer
  • Plan ahead. If you are going to drink while on beta-blockers, make sure you prepare in advance. You can expect a stronger reaction to alcohol and may become extremely dizzy or drowsy. Make sure you have a trusted person to help you if you need it. 

Remember to consult your doctor before you drink alcohol while on beta-blockers.

The Bottom Line

Although not immediately life-threatening, it’s safest not to drink alcohol while taking beta-blockers. The mix of beta-blockers and alcohol can enhance the effects of alcohol and the side effects of the medication. Never skip a dose of your beta-blockers to drink alcohol, but drink in moderation if you want to drink while on beta-blockers.

Picture this: you're enjoying a night out with friends, ready to unwind and let loose, but suddenly you remember you just started a new medication this week — propranolol. Is it still safe to throw back a few drinks?

In this post, you will learn how beta-blockers like propranolol work, how alcohol affects our cardiovascular health, how alcohol interacts with beta-blockers, and how to manage your relationship with alcohol while on beta-blockers. 

What Are Beta-Blockers?

a person pouring pills from a bottle into their other hand

Beta-blockers are a class of medication typically used to treat heart- and circulatory-related problems. However, because beta receptors are found in multiple locations throughout the body, beta-blockers can treat a wide range of problems: 

  • Heart arrhythmias
  • Chest pain (angina) 
  • Coronary artery disease
  • Heart attack or congestive heart failure
  • High blood pressure (hypertension)
  • Enlarged heart
  • Migraines
  • Glaucoma
  • Overactive thyroid (hyperthyroidism) 
  • Anxiety 

These are just some conditions that beta-blockers are used for. But how do beta-blockers work? 

How Do Beta-Blockers Work?

Beta-blockers work by blocking certain hormones from activating beta receptors, also called adrenergic receptors. There are three types of beta receptors: 

  • Beta-1 receptors. When activated, these receptors increase cardiac activity and activate the release of an enzyme found in our kidneys called renin. 
  • Beta-2 receptors. When activated, these relax our airways and lower blood pressure, but they may also cause muscle tremors.
  • Beta-3 receptors. When these are activated, they cause fat cells to break down, increase bladder capacity, and cause tremors. 

Since there are different beta receptors, beta-blockers often selectively target a specific type of beta receptor. Generally, beta-blockers fall into two categories based on whether they are cardioselective (beta-1 receptors) or not. Common cardioselective beta-blockers are atenolol, betaxolol, bisoprolol, esmolol, acebutolol, metoprolol, and nebivolol. Popular nonselective beta-blockers include propranolol, nadolol, pindolol, labetalol, trandate, penbutolol, or sotalol. 

Someone struggling with high blood pressure or anxiety, for example, might be prescribed propranolol, which blocks adrenaline (a stress hormone) from beta-1 receptors. The result is a decreased heart rate, making it easier for the heart to pump blood throughout your body.

While they are usually short-lived and mild, there are some side effects to be aware of: 

  • Feeling tired, dizzy, or lightheaded
  • Having cold fingers or toes 
  • Weight gain
  • Depression
  • Shortness of breath 
  • Difficulties sleeping or having nightmares

Not everyone will experience all the side effects associated with beta-blockers, but it’s good to be aware of them in case you do.

Alcohol’s Effects on the Heart

As we drink alcohol, it gets absorbed through the small intestines to the bloodstream. Once in our bloodstream, it has multiple effects on our cardiovascular system. Let’s take a look at how alcohol consumption affects our heart in the short and long term. 

In the short term, alcohol increases our heart rate and blood pressure and potentially leads to heart palpitations. Heart palpitations are a feeling of having a fast-beating, fluttering, or pounding heart that can feel worrisome, but they are harmless most of the time. After we are done drinking and the alcohol leaves our bloodstream, our blood pressure and heart rate go back to normal. 

When we drink heavily for a long time, we can damage our heart. Heavy drinking can result in tachycardia (when the heart beats too fast), high blood pressure, weakened heart muscles, irregular heartbeat, atrial fibrillation (the heart quivers instead of beats), or an enlarged heart. Many of these long-term effects on the heart can increase the chances of having a heart attack or stroke. Research shows us that heavy drinkers have more strokes and a greater chance of dying from strokes.

Side Effects of Mixing Alcohol and Beta-Blockers

Alcohol and Beta-Blockers

Interactions

Alcohol’s impact on beta-blockers ranges based on the type of beta-blocker. Alcohol and beta-blockers can be a dangerous mix. Alcohol may decrease the effectiveness of beta-blockers by changing how they are released into the body or the speed at which the body metabolizes them. Mixing metoprolol and alcohol, for example, can speed up the release of the drug into our body and decrease its effectiveness. On the other hand, mixing propranolol and alcohol or flecainide and alcohol might not reduce the effectiveness of the drugs but may enhance the effects of alcohol. 

Side Effects

In general, drinking while on beta-blockers can enhance the side effects associated with both alcohol and beta-blockers. Let’s review some side effects associated with drinking alcohol while on beta-blockers: 

  • Excessive sedation and dizziness. Alcohol use and beta-blockers can both cause dizziness and drowsiness. Combining the two can intensify the feelings and lead to more accidents and injuries. 
  • Hypotension. Hypotension is when our blood pressure gets below the normal level. When our blood pressure is too low, we don’t get enough blood to essential areas in our body such as the heart and brain. Beta-blockers and alcohol can lower blood pressure, so having them both can excessively lower our blood pressure and lead to fainting, dizziness, or shock. 
  • Tachycardia. Tachycardia is when our heart rate exceeds 100 beats per minute. Beta-blockers tend to slow our heart rate, and alcohol has the opposite effect. These conflicting actions can lead to tachycardia, irregular heartbeat, or heart palpitations. 
  • Worsened heart conditions. If we are on beta-blockers, we are likely prescribed them to manage issues of the heart. Alcohol consumption can make our heart conditions worse and interferes with the progress we made with the medication. 
  • Liver function. Alcohol is toxic to our liver and can cause long-term damage. Beta-blockers can also negatively impact our liver function, so mixing the two can compound the risks. 

If the associated risks haven’t deterred you, the question remains: can you drink on beta-blockers? While it is likely not life-threatening, most physicians won’t recommend it; however, it will largely depend on the type of beta-blocker in question. If we are using it for heart-related problems, alcohol probably isn’t safe. It’s always best to seek medical advice before we drink alcohol while on beta-blockers. 

Managing Our Relationship With Alcohol While on Beta-Blockers

Even if we know the associated risks, it may be hard to quit our current drinking habits. Let’s go through some tips on how we can have a healthy relationship with alcohol while we are on beta-blockers: 

  • Drink in moderation. Having one or two drinks while on beta-blockers is likely not life-threatening. However, make sure you consult with your prescribing physician before you drink any alcohol. 
  • Don’t skip your beta-blocker! You should never skip a dose of your beta-blocker to drink alcohol. Abruptly stopping beta-blockers can result in a thyroid storm, heart attack, anxiety, or hypertension. A thyroid storm can increase your heart rate, blood pressure, and body temperature to abnormally high levels and be life-threatening. 
  • Skip the alcohol. Instead of drinking alcohol, try alcohol-free alternatives such as mocktails or non-alcoholic beer
  • Plan ahead. If you are going to drink while on beta-blockers, make sure you prepare in advance. You can expect a stronger reaction to alcohol and may become extremely dizzy or drowsy. Make sure you have a trusted person to help you if you need it. 

Remember to consult your doctor before you drink alcohol while on beta-blockers.

The Bottom Line

Although not immediately life-threatening, it’s safest not to drink alcohol while taking beta-blockers. The mix of beta-blockers and alcohol can enhance the effects of alcohol and the side effects of the medication. Never skip a dose of your beta-blockers to drink alcohol, but drink in moderation if you want to drink while on beta-blockers.

Alcohol and Medications
2024-04-27 9:00
Alcohol and Medications
Can You Drink on Macrobid? What Are the Risks?
This is some text inside of a div block.

Macrobid and alcohol don't directly interact. However, mixing the two can still be risky. Check out our latest blog for info on why drinking on Macrobid is not recommended.

15 min read

Prioritize Your Health With Reframe!

Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!

The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.

You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.

Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol. 

And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).

The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today! 

Read Full Article  →

You’ve just been prescribed Macrobid, and you’re ready to finally kick this infection. Especially because tomorrow is your friend’s birthday party — and it’s going to be lit! You’re looking forward to having a few drinks, and you’ve already preordered your Uber for the drive home.

A quick glance at the leaflet from the pharmacy says you should be okay to drink on Macrobid, so you don’t need to worry — right?

Just because we can eat all the cookies in the cookie jar doesn’t mean it’s healthy to do so. Even though there aren’t any direct interactions between alcohol and Macrobid, there can be adverse effects to mixing the two. Let’s examine these effects further; well-informed decisions require well-formed knowledge!

What Is Macrobid?

woman holding a glass of alcohol and a pill

Macrobid (a.k.a., nitrofurantoin) is an antibiotic that is used to treat bacterial infections, most commonly urinary tract infections (UTIs). The antibiotic is different from other, more common antibiotics; it collects in the urine, making it a good choice for infections involving the lower urinary tract. It’s one of the most common prescriptions in the United States with roughly 4 million prescriptions per year. Macrobid only works against bacterial infections, not viral infections of the urinary tract (such as BK virus, adenovirus, or herpes simplex virus). 

The medication starts working within a couple of hours, and it is typically taken for 5-7 days. Several side effects are associated with Macrobid:

  • Nausea 
  • Headache
  • Dizziness
  • Joint or muscle pain
  • Swelling
  • Shortness of breath
  • General discomfort (malaise)

In very rare cases, Macrobid can cause damage to lungs, liver, and nerves. However, Macrobid is regarded as generally safe to use.

Are Macrobid and Nitrofurantoin the Same Thing?

Macrobid is the brand-name version of the generic drug nitrofurantoin. Brand-name Macrobid contains nitrofurantoin in both slow-release macrocrystal form and a quick-acting liquid monohydrate form. Together, this attacks an acute UTI from two angles. (Other nitrofurantoin formulations contain only macrocrystals and are usually used as a preventative to avoid UTIs.)

Our doctor will prescribe the appropriate form of nitrofurantoin to treat our specific circumstances. The most important thing is to take it as prescribed and read all directions and warning labels.

Systemic Effects of Macrobid and Alcohol

So, can you drink alcohol while taking nitrofurantoin? The answer is complicated. Although Macrobid and alcohol don't have any direct interactions, mixing them can interfere with the drug’s effectiveness, damage our liver, and slow down our recovery from infection.

  • Liver metabolization. Most drugs are metabolized by the liver — including Macrobid. Using both at the same time can stress out the liver and inhibit its ability to effectively eliminate the toxic byproducts of alcohol metabolism, possibly leaving us with a nasty hangover. Proper liver function is crucial in helping break down toxins at an appropriate rate to prevent them from causing negative effects on other organs and systems in our body.
  • Decreased immune function. Our immune system’s main role is to help fight infection and keep us healthy. When recovering from a UTI, a strong immune system is critical to eliminating the infection because the Macrobid is only a boost to our body’s natural bacteria-fighting power. Alcohol dampens the function of our immune system, taking away precious resources and prolonging recovery. 

  • Dehydration. Alcohol is a diuretic, meaning it makes us pee. Hydration is essential for treating a UTI because peeing regularly prevents further bacteria growth. While alcohol can cause us to urinate a lot in the short term, the result is that we’re left dehydrated and playing catchup to restore our fluid levels.
  • Medication adherence. Nitrofurantoin is prescribed for 5-7 days to ensure the infection is completely eliminated. Although symptoms may start to go away before then, the entire round of antibiotics is recommended for full effectiveness. Alcohol is correlated with decreased inhibitions and impacted judgment. Research has shown that drinking may influence a patient's adherence to taking daily medication, which may increase the risk of UTI recurrence. 

Despite no acute interactions, it’s clear that alcohol can still interfere with nitrofurantoin. While the above conditions can complicate UTI treatment, there are also some ways that .

Risks of Drinking Alcohol While On Macrobid

Risks of Drinking on Nitrofurantoin

To make more mindful decisions when drinking while on nitrofurantoin, it’s important to know what we may be getting into:

  • Increased side effects. UTIs are painful and unpleasant. Alcohol can further exacerbate symptoms, increase side effects from medication, and heighten the risk of experiencing hangover symptoms — compounding the uncomfortable experience. Choosing to drink while on nitrofurantoin is like holding up a big welcome sign to usher in unpleasant symptoms such as nausea, vomiting, headache, and stomach pain.
  • Decreased effectiveness. Alcohol’s impact on our immune system and hormones can affect our body’s ability to fight against infection — indirectly dampening the effectiveness of nitrofurantoin.
  • Risk of liver damage. Prolonged and excessive drinking is associated with liver damage and disease. When our liver is in overdrive trying to break down alcohol and other drugs in our system, it’s less efficient at eliminating toxic substances that cause damage to our cells and organs. While on nitrofurantoin, alcohol can create the perfect storm that may lead to liver damage or disease.

We may have missed the tiny print on the back of the bottle warning us of these potential risks. If we’ve already had a drink or two while taking nitrofurantoin, should we be concerned?

What To Do If You’ve Already Consumed Alcohol With Nitrofurantoin

First of all: don’t panic! You’re going to be okay; plus, high stress levels can negatively impact recovery and lead us to make rash decisions through black-and-white thinking

Avoid further drinking and make sure to continue taking the medication as directed. Immediate symptoms may not show up after drinking, and it shouldn’t cause any immediate risk to health. If symptoms do arise, keep track of them and reach out to a doctor.

How Long After Taking Nitrofurantoin Can You Drink Alcohol?

Drinking while on nitrofurantoin isn’t recommended, but what about after? Similar to drinking while on the medication, drinking after finishing treatment may not cause immediate risks or direct impacts. However, it’s recommended to wait at least 48 hours after finishing nitrofurantoin to resume drinking.

Even after finishing the round of antibiotics, there’s still the chance of a lingering infection. Take it easy on alcohol — or better yet, avoid it all together — for a week or two after finishing treatment. This allows the body a better chance to fight off any infection that could still be present. Drinking immediately after finishing treatment will not cause any significant dangers (beyond the regular dangers of alcohol), but making intentional choices sets us up for the most successful and safe recovery.

Approaching Safe Consumption of Nitrofurantoin and Alcohol 

If we choose to drink, mindful practices can help minimize potential negative consequences to our recovery from infection. Actioning these four strategies can lead to safer and speedier healing:

  • Practice moderation. Avoid drinking alcohol as much as possible while on nitrofurantoin. Opt for light or non-alcoholic beverages or mocktails, and set limits for yourself when you do go out. Avoiding triggers and standing up to peer pressure are other great ways to reduce overall alcohol consumption. 
  • Monitor symptoms. Tracking your alcohol consumption helps you connect any dots between your drinking and symptoms, and it can help you communicate clearly with your physician. They can offer personalized advice based on your unique health needs.
  • Adhere to the medication cycle. Completing the entire cycle of antibiotics is necessary to ensure the best chance of completely eliminating the infection. Always take your medication as prescribed. If you know we’ll be out for the night and may forget to take it the morning after, it’s helpful to set an alarm or designate an accountability buddy.
  • Maintain nutrition and hydration. Proper nutrition and hydration are key for fighting off infections. If you’re planning to drink, prioritize eating a balanced meal that supports your liver and consider giving your liver a boost with a next-day liver detox drink. Maintain hydration by keeping a water bottle handy and supplementing with electrolytes.

Moving Forward

Macrobid and nitrofurantoin are short-term antibiotics that help to treat UTIs. Although not immediately dangerous, mixing alcohol and Macrobid puts unnecessary stress on our body and increases the possibility of unpleasant symptoms and complications.

If we choose to drink, implementing mindful drinking practices can minimize risks. Keeping these strategies in our back pocket can be helpful for practicing safe alcohol consumption in other scenarios as well. Here’s to a healthy tomorrow!

You’ve just been prescribed Macrobid, and you’re ready to finally kick this infection. Especially because tomorrow is your friend’s birthday party — and it’s going to be lit! You’re looking forward to having a few drinks, and you’ve already preordered your Uber for the drive home.

A quick glance at the leaflet from the pharmacy says you should be okay to drink on Macrobid, so you don’t need to worry — right?

Just because we can eat all the cookies in the cookie jar doesn’t mean it’s healthy to do so. Even though there aren’t any direct interactions between alcohol and Macrobid, there can be adverse effects to mixing the two. Let’s examine these effects further; well-informed decisions require well-formed knowledge!

What Is Macrobid?

woman holding a glass of alcohol and a pill

Macrobid (a.k.a., nitrofurantoin) is an antibiotic that is used to treat bacterial infections, most commonly urinary tract infections (UTIs). The antibiotic is different from other, more common antibiotics; it collects in the urine, making it a good choice for infections involving the lower urinary tract. It’s one of the most common prescriptions in the United States with roughly 4 million prescriptions per year. Macrobid only works against bacterial infections, not viral infections of the urinary tract (such as BK virus, adenovirus, or herpes simplex virus). 

The medication starts working within a couple of hours, and it is typically taken for 5-7 days. Several side effects are associated with Macrobid:

  • Nausea 
  • Headache
  • Dizziness
  • Joint or muscle pain
  • Swelling
  • Shortness of breath
  • General discomfort (malaise)

In very rare cases, Macrobid can cause damage to lungs, liver, and nerves. However, Macrobid is regarded as generally safe to use.

Are Macrobid and Nitrofurantoin the Same Thing?

Macrobid is the brand-name version of the generic drug nitrofurantoin. Brand-name Macrobid contains nitrofurantoin in both slow-release macrocrystal form and a quick-acting liquid monohydrate form. Together, this attacks an acute UTI from two angles. (Other nitrofurantoin formulations contain only macrocrystals and are usually used as a preventative to avoid UTIs.)

Our doctor will prescribe the appropriate form of nitrofurantoin to treat our specific circumstances. The most important thing is to take it as prescribed and read all directions and warning labels.

Systemic Effects of Macrobid and Alcohol

So, can you drink alcohol while taking nitrofurantoin? The answer is complicated. Although Macrobid and alcohol don't have any direct interactions, mixing them can interfere with the drug’s effectiveness, damage our liver, and slow down our recovery from infection.

  • Liver metabolization. Most drugs are metabolized by the liver — including Macrobid. Using both at the same time can stress out the liver and inhibit its ability to effectively eliminate the toxic byproducts of alcohol metabolism, possibly leaving us with a nasty hangover. Proper liver function is crucial in helping break down toxins at an appropriate rate to prevent them from causing negative effects on other organs and systems in our body.
  • Decreased immune function. Our immune system’s main role is to help fight infection and keep us healthy. When recovering from a UTI, a strong immune system is critical to eliminating the infection because the Macrobid is only a boost to our body’s natural bacteria-fighting power. Alcohol dampens the function of our immune system, taking away precious resources and prolonging recovery. 

  • Dehydration. Alcohol is a diuretic, meaning it makes us pee. Hydration is essential for treating a UTI because peeing regularly prevents further bacteria growth. While alcohol can cause us to urinate a lot in the short term, the result is that we’re left dehydrated and playing catchup to restore our fluid levels.
  • Medication adherence. Nitrofurantoin is prescribed for 5-7 days to ensure the infection is completely eliminated. Although symptoms may start to go away before then, the entire round of antibiotics is recommended for full effectiveness. Alcohol is correlated with decreased inhibitions and impacted judgment. Research has shown that drinking may influence a patient's adherence to taking daily medication, which may increase the risk of UTI recurrence. 

Despite no acute interactions, it’s clear that alcohol can still interfere with nitrofurantoin. While the above conditions can complicate UTI treatment, there are also some ways that .

Risks of Drinking Alcohol While On Macrobid

Risks of Drinking on Nitrofurantoin

To make more mindful decisions when drinking while on nitrofurantoin, it’s important to know what we may be getting into:

  • Increased side effects. UTIs are painful and unpleasant. Alcohol can further exacerbate symptoms, increase side effects from medication, and heighten the risk of experiencing hangover symptoms — compounding the uncomfortable experience. Choosing to drink while on nitrofurantoin is like holding up a big welcome sign to usher in unpleasant symptoms such as nausea, vomiting, headache, and stomach pain.
  • Decreased effectiveness. Alcohol’s impact on our immune system and hormones can affect our body’s ability to fight against infection — indirectly dampening the effectiveness of nitrofurantoin.
  • Risk of liver damage. Prolonged and excessive drinking is associated with liver damage and disease. When our liver is in overdrive trying to break down alcohol and other drugs in our system, it’s less efficient at eliminating toxic substances that cause damage to our cells and organs. While on nitrofurantoin, alcohol can create the perfect storm that may lead to liver damage or disease.

We may have missed the tiny print on the back of the bottle warning us of these potential risks. If we’ve already had a drink or two while taking nitrofurantoin, should we be concerned?

What To Do If You’ve Already Consumed Alcohol With Nitrofurantoin

First of all: don’t panic! You’re going to be okay; plus, high stress levels can negatively impact recovery and lead us to make rash decisions through black-and-white thinking

Avoid further drinking and make sure to continue taking the medication as directed. Immediate symptoms may not show up after drinking, and it shouldn’t cause any immediate risk to health. If symptoms do arise, keep track of them and reach out to a doctor.

How Long After Taking Nitrofurantoin Can You Drink Alcohol?

Drinking while on nitrofurantoin isn’t recommended, but what about after? Similar to drinking while on the medication, drinking after finishing treatment may not cause immediate risks or direct impacts. However, it’s recommended to wait at least 48 hours after finishing nitrofurantoin to resume drinking.

Even after finishing the round of antibiotics, there’s still the chance of a lingering infection. Take it easy on alcohol — or better yet, avoid it all together — for a week or two after finishing treatment. This allows the body a better chance to fight off any infection that could still be present. Drinking immediately after finishing treatment will not cause any significant dangers (beyond the regular dangers of alcohol), but making intentional choices sets us up for the most successful and safe recovery.

Approaching Safe Consumption of Nitrofurantoin and Alcohol 

If we choose to drink, mindful practices can help minimize potential negative consequences to our recovery from infection. Actioning these four strategies can lead to safer and speedier healing:

  • Practice moderation. Avoid drinking alcohol as much as possible while on nitrofurantoin. Opt for light or non-alcoholic beverages or mocktails, and set limits for yourself when you do go out. Avoiding triggers and standing up to peer pressure are other great ways to reduce overall alcohol consumption. 
  • Monitor symptoms. Tracking your alcohol consumption helps you connect any dots between your drinking and symptoms, and it can help you communicate clearly with your physician. They can offer personalized advice based on your unique health needs.
  • Adhere to the medication cycle. Completing the entire cycle of antibiotics is necessary to ensure the best chance of completely eliminating the infection. Always take your medication as prescribed. If you know we’ll be out for the night and may forget to take it the morning after, it’s helpful to set an alarm or designate an accountability buddy.
  • Maintain nutrition and hydration. Proper nutrition and hydration are key for fighting off infections. If you’re planning to drink, prioritize eating a balanced meal that supports your liver and consider giving your liver a boost with a next-day liver detox drink. Maintain hydration by keeping a water bottle handy and supplementing with electrolytes.

Moving Forward

Macrobid and nitrofurantoin are short-term antibiotics that help to treat UTIs. Although not immediately dangerous, mixing alcohol and Macrobid puts unnecessary stress on our body and increases the possibility of unpleasant symptoms and complications.

If we choose to drink, implementing mindful drinking practices can minimize risks. Keeping these strategies in our back pocket can be helpful for practicing safe alcohol consumption in other scenarios as well. Here’s to a healthy tomorrow!

Alcohol and Medications
2024-04-27 9:00
Alcohol and Medications
Can You Drink on Metronidazole?
This is some text inside of a div block.

Taking metronidazole and wondering what happens if you mix it with alcohol? Our latest blog has the answers!

18 min read

Ready To Meet the Healthiest Version of Yourself? Try Reframe!

Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!

The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.

You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.

Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol. 

And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).

The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today! 

Read Full Article  →

It’s a common story: you go to a doctor, walk away with a prescription for your condition, then drive to your local pharmacy to pick it up. You’re excited, thinking how much better you’ll feel soon. You take it out of the crinkly paper bag, tear off what seems like an entire stack of papers with information in tiny print stapled onto it, and glance at it before tossing it into the recycling bin. Then something on the orange bottle catches your eye — that little wine glass with a line across it: “Don’t consume with alcohol!”

Yikes. It’s too late to get all those papers back to find out why, so you take your questions to Google: “Can you drink on metronidazole?” It’s probably not that bad, right? What’s all this about the Disulfiram-like reaction between metronidazole and booze? Before you give yourself a panic attack searching for things like “Can metronidazole and alcohol kill you?” let’s get the facts straight. What exactly happens if you accidentally drink alcohol while taking metronidazole?

What Is Metronidazole?

A person's hand holding a glass of whiskey with ice cubes

According to the National Library of Medicine, Metronidazole (better known by the brand name Flagyl) is one of the go-to drugs for the treatment of infections. It’s equipped to handle several conditions:

  • Intestinal amebiases
  • Liver amebiasis
  • Bacterial septicemia
  • Bone and joint infections
  • Meningitis
  • Brain abscess
  • Endocarditis
  • Endometritis
  • Bacterial vaginosis
  • Intra-abdominal infections
  • Lower respiratory tract infections
  • Skin structure infections
  • Surgical prophylaxis colorectal surgeries

That’s quite a long job description! And there’s even more. Topical metronidazole can treat a few gnarly infections, such as rosacea and bacterial vaginosis. Plus, it has several off-label uses:

  • Bite wound infections from animal
  • Infections from human bites (eek!)
  • Clostridioides (formerly Clostridium difficile)
  • Crohn’s disease
  • Post-surgical resection management
  • Giardiasis
  • Periodontitis
  • Tetanus

How Does Metronidazole Work?

Flagyl works by attacking bacterial DNA through a 4-step process. Here’s the gist:

  1. Breaking the barrier and taking out the anaerobes. Metronidazole breaks through the cell barriers of anaerobic and aerobic bacteria but only kills the first type of pathogen.
  2. Upgrading equipment. With the anaerobes out of the way, it’s time to attack the second enemy! However, this requires different equipment. Metronidazole undergoes reductive activation by special proteins which change its chemical structure to allow it to torpedo the aerobes.
  3. Storming the command center. The next step? Destroying the “enemy’s” DNA. Metronidazole interacts with the host cells’ DNA, resulting in breakage and “fatal destabilization.”
  4. Cleaning up the mess. Final step? Breaking down the toxic byproducts of the reaction.

While Metronidazole is quickly absorbed, it might take a couple of days to start feeling better. However, once it gets going, the medication does a powerful job of clearing out the infection.

Can You Drink On Metronidazole?

In general, Flagyl doesn’t mix well with other substances, including alcohol. This isn’t all that surprising — for one thing, alcohol tends to intensify the side effects of many medications. Here are the side effects of metronidazole:

  • Headaches. Many people on metronidazole experience headaches. Since alcohol is known for causing the notorious “cocktail headaches,” adding it to the mix isn’t doing us any favors.
  • Digestive disruption. Some have gastrointestinal effects, including loss of appetite, nausea and vomiting, diarrhea, heartburn, or cramping in the stomach area, and constipation while taking metronidazole. Alcohol can disrupt digestion, causing nausea, heartburn, and even leading to gastritis. Needless to say, this makes for a potentially stomach-turning combo!
  • Metallic taste. Metronidazole might also cause a metallic taste in our mouth — so whatever we’re drinking might not taste that great.

In addition to these common side effects, there are some potentially serious (but rare) side effects of metronidazole that don’t mix well with booze:

  • Seizures. The potentially serious side effects of Metronidazole include seizures. In large amounts, alcohol has been known to induce seizures as well (as does alcohol withdrawal), so combining the two could be even more dangerous. It’s important to stay vigilant and be aware of tell-tale symptoms such as unusual behaviors or sensations, uncontrollable movements, or, in severe cases, loss of consciousness.
  • Cancer risk. As the warning label on metronidazole says, it may also be carcinogenic based on animal studies. Given that alcohol is a known carcinogen as well, the combo isn’t great.
  • Possible brain damage. If used for a long time, metronidazole could be neurotoxic. Knowing what alcohol does to our brain, the mixture of the two could cause serious trouble.
Staying Safe When Drinking on Metronidazole

How Long After Taking Metronidazole Can I Drink Alcohol?

Still, disulfiram-like reaction or not, metronidazole does interact with alcohol in potentially problematic ways, so the recommended wait period is at least two weeks for disulfiram and three days for alcohol after taking it.

Metronidazole and Alcohol: What Else Is Behind the Warning?

If you’re taking disulfiram — a medication used to treat alcohol use disorder (AUD) — there’s yet another reason to pause and reconsider before taking metronidazole.

Disulfiram works by causing extremely unpleasant side effects, such as facial flushing, nausea, and cardiovascular abnormalities. The idea is that taking disulfiram will make drinking so unenjoyable we won’t want to do it anymore. (For more details, check out our blog: “How Does Disulfiram Work?”)

What does any of this have to do with Flagyl? As it turns out, metronidazole has a negative, and potentially dangerous interaction with both alcohol and disulfiram.

Let’s look at both effects in a bit more detail:

  1. Metronidazole is thought to induce a “Disulfiram-like” reaction when mixed with alcohol. When we combine alcohol with metronidazole, we might experience nausea, vomiting, stomach cramps, headaches, and facial flushing. According to a recent study, it doesn’t make much to trigger the reaction!
  2. Metronidazole also doesn't mix well with disulfiram. Taking both medications puts us at risk of hallucinations and psychosis (definitely not what we want, especially when we’re already not feeling our best!).

Negative Interactions Between Metronidazole and Alcohol: Myth or Science?

Some scientists now think that the side effects of mixing metronidazole and alcohol are a myth.

According to an Emergency Medical News article, doctors have been warning patients against mixing the two for years to avoid a “disulfiram-like reaction.” And yet, the author asks:

“If this interaction is so important, where were the cases? Millions of prescriptions for metronidazole are written each year. Despite clear warnings, it's inevitable that a significant number of patients would continue to consume alcohol with the drug. Yet I've never seen a patient come in with a disulfiram-like reaction from that combination. Is the metronidazole-ethanol drug interaction really a thing?”

The author goes on to explain how the accumulation of acetaldehyde is responsible for the disulfiram reaction, and how the “original thinking” was that metronidazole also blocked its breakdown. However, as he points out, recent evidence shows that this might not be the case. When 18 patients who were on metronidazole were compared with a control group who had a similar blood alcohol concentration, none seemed to show any signs of a disulfiram-like reaction.

Likewise, a study in WMJ set out to investigate whether or not there was any truth to the disulfiram-like reaction claims and found that the answer isn’t as clear as scientists once thought. Their findings suggest that there’s no increase in acetaldehyde when both substances are present in our system.

What If I Already Had a Drink?

Some of us might be thinking, “Oh no! What if I accidentally drank alcohol while taking metronidazole?” That warning label on the medicine package could be easy to miss.

First of all, don’t panic. This probably happens quite often, and usually leads to no harmful effects, according to the Emergency Medical News study. However, it’s good to keep in mind that this is just one study arguing against the negative effects, and even if the “metronidazole and alcohol myth” is responsible for the alcohol warning, there are still other reasons why Flagyl and alcohol are not a good mix.

So, can metronidazole and alcohol kill you? It almost certainly won’t, especially given the evidence that there might not be a disulfiram-like reaction at play after all.

Still, it’s best to stay vigilant and avoid mixing metronidazole and alcohol. And if there’s any doubt in your mind at all that you’re having a dangerous reaction, please don’t hesitate to call your doctor immediately! There are many individual factors at play here, so erring on the side of safety is key.

Tips To Stay Safe

So how can we stay safe while taking metronidazole and trying to stay away from booze for the time being (or, perhaps, for even longer)? Here are a few ideas:

  1. Avoid the mix. Mixing alcohol and metronidazole is asking for trouble. Instead, focus on healing and nourishing your body with plenty of water and vitamin-rich foods. You’ll heal faster and your body will thank you!
  2. Follow your doctor’s advice. Always follow your physician’s advice about taking medications, and don’t hesitate to ask if you have questions. They’re there to help!
  3. Get support. If you’re having trouble staying booze-free, find like-minded people who will be happy to support you. They can be friends, family members, or others just like you who are already part of the Reframe community! Everyone’s alcohol journey is different, so whatever your goals are, you’re bound to find helpful advice and support.
  4. Get sober curious. Use this time as an opportunity to explore a sober curious lifestyle. Approach it as an experiment — what if instead of having a glass of wine with dinner you had a fun mocktail instead? Who knows, you might find a new favorite! Plus, a hydrating, nutritious drink is bound to make you feel better as you heal.

Summing Up

In the end, as with any situation that compels us to set alcohol aside for a bit, it’s always best to see the situation as an opportunity. Perhaps it’s even a blessing in disguise! Who knows, by going booze-free for a few days or weeks, you might discover new activities you love or find that you enjoy waking up feeling refreshed. Maybe your skin looks better, or maybe you’ve even dropped some weight. All in all, you might see that cutting back is something you want to continue in the long run to see what new benefits are waiting for you (and trust us, there are lots!). If so, Reframe is here to help you and cheer you on every step of the way.

It’s a common story: you go to a doctor, walk away with a prescription for your condition, then drive to your local pharmacy to pick it up. You’re excited, thinking how much better you’ll feel soon. You take it out of the crinkly paper bag, tear off what seems like an entire stack of papers with information in tiny print stapled onto it, and glance at it before tossing it into the recycling bin. Then something on the orange bottle catches your eye — that little wine glass with a line across it: “Don’t consume with alcohol!”

Yikes. It’s too late to get all those papers back to find out why, so you take your questions to Google: “Can you drink on metronidazole?” It’s probably not that bad, right? What’s all this about the Disulfiram-like reaction between metronidazole and booze? Before you give yourself a panic attack searching for things like “Can metronidazole and alcohol kill you?” let’s get the facts straight. What exactly happens if you accidentally drink alcohol while taking metronidazole?

What Is Metronidazole?

A person's hand holding a glass of whiskey with ice cubes

According to the National Library of Medicine, Metronidazole (better known by the brand name Flagyl) is one of the go-to drugs for the treatment of infections. It’s equipped to handle several conditions:

  • Intestinal amebiases
  • Liver amebiasis
  • Bacterial septicemia
  • Bone and joint infections
  • Meningitis
  • Brain abscess
  • Endocarditis
  • Endometritis
  • Bacterial vaginosis
  • Intra-abdominal infections
  • Lower respiratory tract infections
  • Skin structure infections
  • Surgical prophylaxis colorectal surgeries

That’s quite a long job description! And there’s even more. Topical metronidazole can treat a few gnarly infections, such as rosacea and bacterial vaginosis. Plus, it has several off-label uses:

  • Bite wound infections from animal
  • Infections from human bites (eek!)
  • Clostridioides (formerly Clostridium difficile)
  • Crohn’s disease
  • Post-surgical resection management
  • Giardiasis
  • Periodontitis
  • Tetanus

How Does Metronidazole Work?

Flagyl works by attacking bacterial DNA through a 4-step process. Here’s the gist:

  1. Breaking the barrier and taking out the anaerobes. Metronidazole breaks through the cell barriers of anaerobic and aerobic bacteria but only kills the first type of pathogen.
  2. Upgrading equipment. With the anaerobes out of the way, it’s time to attack the second enemy! However, this requires different equipment. Metronidazole undergoes reductive activation by special proteins which change its chemical structure to allow it to torpedo the aerobes.
  3. Storming the command center. The next step? Destroying the “enemy’s” DNA. Metronidazole interacts with the host cells’ DNA, resulting in breakage and “fatal destabilization.”
  4. Cleaning up the mess. Final step? Breaking down the toxic byproducts of the reaction.

While Metronidazole is quickly absorbed, it might take a couple of days to start feeling better. However, once it gets going, the medication does a powerful job of clearing out the infection.

Can You Drink On Metronidazole?

In general, Flagyl doesn’t mix well with other substances, including alcohol. This isn’t all that surprising — for one thing, alcohol tends to intensify the side effects of many medications. Here are the side effects of metronidazole:

  • Headaches. Many people on metronidazole experience headaches. Since alcohol is known for causing the notorious “cocktail headaches,” adding it to the mix isn’t doing us any favors.
  • Digestive disruption. Some have gastrointestinal effects, including loss of appetite, nausea and vomiting, diarrhea, heartburn, or cramping in the stomach area, and constipation while taking metronidazole. Alcohol can disrupt digestion, causing nausea, heartburn, and even leading to gastritis. Needless to say, this makes for a potentially stomach-turning combo!
  • Metallic taste. Metronidazole might also cause a metallic taste in our mouth — so whatever we’re drinking might not taste that great.

In addition to these common side effects, there are some potentially serious (but rare) side effects of metronidazole that don’t mix well with booze:

  • Seizures. The potentially serious side effects of Metronidazole include seizures. In large amounts, alcohol has been known to induce seizures as well (as does alcohol withdrawal), so combining the two could be even more dangerous. It’s important to stay vigilant and be aware of tell-tale symptoms such as unusual behaviors or sensations, uncontrollable movements, or, in severe cases, loss of consciousness.
  • Cancer risk. As the warning label on metronidazole says, it may also be carcinogenic based on animal studies. Given that alcohol is a known carcinogen as well, the combo isn’t great.
  • Possible brain damage. If used for a long time, metronidazole could be neurotoxic. Knowing what alcohol does to our brain, the mixture of the two could cause serious trouble.
Staying Safe When Drinking on Metronidazole

How Long After Taking Metronidazole Can I Drink Alcohol?

Still, disulfiram-like reaction or not, metronidazole does interact with alcohol in potentially problematic ways, so the recommended wait period is at least two weeks for disulfiram and three days for alcohol after taking it.

Metronidazole and Alcohol: What Else Is Behind the Warning?

If you’re taking disulfiram — a medication used to treat alcohol use disorder (AUD) — there’s yet another reason to pause and reconsider before taking metronidazole.

Disulfiram works by causing extremely unpleasant side effects, such as facial flushing, nausea, and cardiovascular abnormalities. The idea is that taking disulfiram will make drinking so unenjoyable we won’t want to do it anymore. (For more details, check out our blog: “How Does Disulfiram Work?”)

What does any of this have to do with Flagyl? As it turns out, metronidazole has a negative, and potentially dangerous interaction with both alcohol and disulfiram.

Let’s look at both effects in a bit more detail:

  1. Metronidazole is thought to induce a “Disulfiram-like” reaction when mixed with alcohol. When we combine alcohol with metronidazole, we might experience nausea, vomiting, stomach cramps, headaches, and facial flushing. According to a recent study, it doesn’t make much to trigger the reaction!
  2. Metronidazole also doesn't mix well with disulfiram. Taking both medications puts us at risk of hallucinations and psychosis (definitely not what we want, especially when we’re already not feeling our best!).

Negative Interactions Between Metronidazole and Alcohol: Myth or Science?

Some scientists now think that the side effects of mixing metronidazole and alcohol are a myth.

According to an Emergency Medical News article, doctors have been warning patients against mixing the two for years to avoid a “disulfiram-like reaction.” And yet, the author asks:

“If this interaction is so important, where were the cases? Millions of prescriptions for metronidazole are written each year. Despite clear warnings, it's inevitable that a significant number of patients would continue to consume alcohol with the drug. Yet I've never seen a patient come in with a disulfiram-like reaction from that combination. Is the metronidazole-ethanol drug interaction really a thing?”

The author goes on to explain how the accumulation of acetaldehyde is responsible for the disulfiram reaction, and how the “original thinking” was that metronidazole also blocked its breakdown. However, as he points out, recent evidence shows that this might not be the case. When 18 patients who were on metronidazole were compared with a control group who had a similar blood alcohol concentration, none seemed to show any signs of a disulfiram-like reaction.

Likewise, a study in WMJ set out to investigate whether or not there was any truth to the disulfiram-like reaction claims and found that the answer isn’t as clear as scientists once thought. Their findings suggest that there’s no increase in acetaldehyde when both substances are present in our system.

What If I Already Had a Drink?

Some of us might be thinking, “Oh no! What if I accidentally drank alcohol while taking metronidazole?” That warning label on the medicine package could be easy to miss.

First of all, don’t panic. This probably happens quite often, and usually leads to no harmful effects, according to the Emergency Medical News study. However, it’s good to keep in mind that this is just one study arguing against the negative effects, and even if the “metronidazole and alcohol myth” is responsible for the alcohol warning, there are still other reasons why Flagyl and alcohol are not a good mix.

So, can metronidazole and alcohol kill you? It almost certainly won’t, especially given the evidence that there might not be a disulfiram-like reaction at play after all.

Still, it’s best to stay vigilant and avoid mixing metronidazole and alcohol. And if there’s any doubt in your mind at all that you’re having a dangerous reaction, please don’t hesitate to call your doctor immediately! There are many individual factors at play here, so erring on the side of safety is key.

Tips To Stay Safe

So how can we stay safe while taking metronidazole and trying to stay away from booze for the time being (or, perhaps, for even longer)? Here are a few ideas:

  1. Avoid the mix. Mixing alcohol and metronidazole is asking for trouble. Instead, focus on healing and nourishing your body with plenty of water and vitamin-rich foods. You’ll heal faster and your body will thank you!
  2. Follow your doctor’s advice. Always follow your physician’s advice about taking medications, and don’t hesitate to ask if you have questions. They’re there to help!
  3. Get support. If you’re having trouble staying booze-free, find like-minded people who will be happy to support you. They can be friends, family members, or others just like you who are already part of the Reframe community! Everyone’s alcohol journey is different, so whatever your goals are, you’re bound to find helpful advice and support.
  4. Get sober curious. Use this time as an opportunity to explore a sober curious lifestyle. Approach it as an experiment — what if instead of having a glass of wine with dinner you had a fun mocktail instead? Who knows, you might find a new favorite! Plus, a hydrating, nutritious drink is bound to make you feel better as you heal.

Summing Up

In the end, as with any situation that compels us to set alcohol aside for a bit, it’s always best to see the situation as an opportunity. Perhaps it’s even a blessing in disguise! Who knows, by going booze-free for a few days or weeks, you might discover new activities you love or find that you enjoy waking up feeling refreshed. Maybe your skin looks better, or maybe you’ve even dropped some weight. All in all, you might see that cutting back is something you want to continue in the long run to see what new benefits are waiting for you (and trust us, there are lots!). If so, Reframe is here to help you and cheer you on every step of the way.

Alcohol and Medications
2024-04-26 9:00
Alcohol and Medications
Can You Drink on Mucinex?
This is some text inside of a div block.

Taking Mucinex this cold season and wondering if drinking on Mucinex is a bad idea? Find out why the two are not a great mix in our latest blog!

17 min read

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Mucinex and Alcohol: The Risks

Mucinex used to run commercials featuring “Mr. Mucus,” the lovable green and slimy antihero that the sinus-saving, cold-clearing medicine promises to sweep out of your nasal passages. So when you wake up clogged up and groggy, your eyes stinging and your m’s sounding like b’s when you talk, reaching for that trusty bottle of Mucinex can bring much-needed relief. But then you remember that beer you had before bed. Is it safe to take Mucinex after drinking? Should you wait? Let’s find out more!

What Is Mucinex and What Is It Used For?

As Mr. Mucus shows us, Mucinex is quite the multitasker. The active ingredient, guaifenesin, helps loosen up mucus to flush it out of the body.

A woman sitting on a bed, blowing her nose into a tissue

While it might sound like something that came out of test tubes in the lab, guaifenesin is as natural as it gets. According to The Encyclopedia of Toxicology, it was “originally derived from the guaiac tree and used by Native Americans for health purposes.” Having caught on to its medicinal magic, scientists began to synthesize it in 1912. However, it took 77 years for the FDA to officially approve Mucinex in 1989 and another 15 for Mr. Mucus to officially enter the scene as its mascot in 2004.

From pills to syrups, Mucinex comes in all shapes and sizes. It also “plays well” with other meds and is often combined with antihistamines, cough suppressants, and decongestants.

While Mucinex is a very popular version of guaifenesin (thanks in part to Mr. Mucus and his marketing power), the medication comes under many other brand aliases:

  • Air Power (the dairy-free, vegan version produced by Nature’s Way)
  • Cough Out (just guaifenesin under a different name) 
  • Equaline Tussin and Equate Tussin (also containing dextromethorphan)
  • Good Neighbor Pharmacy Tussin (a “neighborly” mix of dextromethorphan hydrobromide, guaifenesin, and phenylephrine hydrochloride)
  • Good Sense Tussin (guaifenesin with dextromethorphan)
  • Guiatuss (combined with codeine, available by prescription)
  • Leader Adult Tussin (another guaifenesin and dextromethorphan combo) 
  • Leader Mucus Relief (a mix of guaifenesin, hypromellose, magnesium stearate, maltodextrin, microcrystalline cellulose, polyethylene glycol, povidone, silicon dioxide, sodium starch glycolate, stearic acid)
  • Liqufruta (herbal garlic cough syrup with guaifenesin)
  • Refenesen Chest Congestion Relief (also contains phenylephrine)
  • Robitussin Chest Congestion (also contains dextromethorphan)
  • Siltussin (a liquid form of guaifenesin with a twist — this one tastes like strawberries)
  • Wal Tussin (Walgreens’ take on the dextromethorphan-guaifenesin combo)

Many other pharmacies and stores might have their own brand as well; it’s a tried-and-true remedy for congestion!

Can You Drink on Mucinex?

In short, alcohol and Mucinex are not a great mix. To understand why, let’s first take a look at the common side effects Mucinex is known for:

  • Nausea and vomiting. Mucinex can irritate the stomach lining, making us feel queasy or even causing us to throw up. 
  • Drowsiness. Like many other cold medications, Mucinex can make us nod off or feel a bit more drowsy than usual.
  • Headaches. Another pesky side effect some folks experience is headaches. Hint: staying hydrated can help!
  • Dizziness. Mucinex can affect our inner ear, temporarily throwing us off balance. It could also tweak our blood pressure a bit, causing minor fluctuations. Neither of these is a huge deal — it’s a bit like the feeling of standing up too quickly.


None of these are a huge deal on their own, but what happens when we mix them with alcohol? Let’s find out why combining the two is asking for trouble.

Alcohol and Mucinex: Worsened Side Effects 

Now that we have an idea of the side effects of Mucinex, we can see that adding alcohol to the mix isn’t the best idea. When we drink alcohol alongside Mucinex, we run the risk of worsening side effects: 

  • Sedation struggles. Alcohol is a known depressant, which slows down our central nervous system (CNS). And while guaifenesin’s CNS effects with guaifenesin are minimal, the mix could potentially make us extra drowsy and dizzy.
  • Hefty headaches. Both alcohol and Mucinex can cause headaches, so putting the two together is asking for trouble. As if having a cold doesn’t dehydrate us enough, alcohol can cause further dehydration and, consequently, headaches. Alcohol also causes vasodilation, increasing blood flow (and pressure) to the brain. The buildup of acetaldehyde — a toxic byproduct of alcohol metabolism — turns up the headache dial even more.
  • Tummy troubles. We know that Mucinex can be hard on the stomach, and alcohol is even worse. Alcohol amps up stomach acid production, leading to irritation, nausea, and acid reflux. Over time, it could cause problems such as gastritis or stomach ulcers! (For a deeper look, check out our blog: “5 Ways Alcohol Affects the Stomach and Digestive System.”)

All of these symptoms can only make us more miserable when we are sick. But there are even more dangers to drinking alcohol with Mucinex. Let’s take a look. 

Alcohol, Mucinex, and the Liver 

Guaifenesin and alcohol are both metabolized by the liver, which can get overwhelmed by the dual task of digesting both. Even worse, overtasking the liver can lead to a buildup of acetaldehyde, which contributes to hangovers and can even cause serious illnesses in the long run.

Beyond Guaifenesin: Additional Ingredients in Mucinex

Another potential pitfall with combining Mucinex and alcohol? Guaifenesin may not be the only med in the mix. Many formulas that contain it have other ingredients to tackle all those additional cold-related symptoms, such as body aches and pains, cough, headaches, and sinus pain. And once again, most of them are not booze-friendly either: 

  • Dextromethorphan (DXM). According to WebMD, DXM is used to ease cough caused by infections of the air passages triggered by sinusitis or colds. It’s often included in Mucinex as one of the ingredients. 

    The problem with mixing DXM and alcohol? According to Drugs.com, on the lighter side, we could be looking at dizziness, drowsiness, and concentration difficulties. And if things get more serious, there’s a chance of more serious “impairment in thinking and judgment.”
  • Acetaminophen. This one is a bad match for alcohol as well. The liver metabolizes both, so combining the two could lead to toxicity. (For more insight into liver damage from alcohol, take a look at “How Much Alcohol Causes Liver Damage?”).
  • Pseudoephedrine and phenylephrine. These two are great at helping us breathe more easily, but together with alcohol, pseudoephedrine in particular can be bad news. As a central nervous stimulant, it clashes with the depressant effects of booze and strains the heart. Moreover, the dizziness caused by all three — guaifenesin, pseudoephedrine, and alcohol — is a trip-and-fall waiting to happen, especially when we’re already under the weather.

If we’re nursing a cold, it’s better to avoid alcohol altogether. It will not only keep us safe but help us recover faster!

Get Well Later: Alcohol, Mucinex, and the Immune System

Finally, mixing alcohol and Mucinex doesn’t do us any favors when it comes to the reason we’re taking Mucinex in the first place.

For one thing, alcohol can throw a wrench in the workings of our immune system and isn’t the best ally in recovery from illness in general. (For more details, take a look at our blog “Alcohol's Impact on the Immune System.”)

Moreover, alcohol is a notorious diuretic that inhibits the release of the hormone in charge of telling our kidneys to hold onto water. And while Mucinex isn’t dehydrating per se, the cold itself is. So, adding booze to the mix dries up our body — and especially our sensitive nasal passages — even more.

How Many Hours After Taking Mucinex Should I Wait To Drink Alcohol? 

Doctors say to wait at least 12 hours to be safe. But if you have any concerns or are taking additional medications, always check with yours! They know you best and will be able to offer advice that’s tailored to your needs and situation.

How much alcohol is too much? Michigan State professor and physician James J. Galligan said in an interview with Self, “There are many drugs that can interact with alcohol resulting in loss of memory and consciousness … Even one or two drinks can interact with some drugs to produce severe intoxication and potentially loss of consciousness in some people.”

Another physician, David Cutler, clarifies that having a single drink probably won’t be the end of the world. Still, it’s not a great idea: “The problem is that people often think that if they feel OK after having one drink, they can have two, and things go downhill from there. Also, just because you’re probably OK if you stick with one drink doesn’t mean you can’t have a bad reaction. ‘It’s not that you’ll never have one, it’s just unlikely.’”

Tips To Stay Safe and Get Well When Taking Mucinex

Tips To Stay Safe and Get Well

To help you stay safe while taking Mucinex — as well as after you recover — consider these tips:

  1. Watch your intake. If alcohol has become a frequent habit, taking a break might seem a bit tough at first, but look at it as an opportunity to explore a healthier lifestyle! It’s best to avoid mixing alcohol and Mucinex to avoid a potentially dangerous mix of side effects, among other reasons.
  2. Hydrate. Hydration is crucial every day, but it’s especially important when we’re sick. Dehydration can also make Mucinex side effects such as nausea and headaches worse, so drink up!
  3. Nourish your body. Remember how your mom told you to “feed a cold”? Nutritious food is always important, but it’s especially crucial when we’re under the weather. Chicken soup is an old favorite for a reason — the warm brew is soothing for the throat and sinuses, while the chicken provides some much-needed energy. And those vitamin-packed veggies? An added boost for your immune system!
  4. Try some ginger tea. Ginger tea is known for its anti-nausea properties, plus it’s soothing! So if your cold (and Mucinex) are making you queasy, this time-tested cure could work wonders!
  5. Take time to heal. Take this time as an opportunity to enjoy some booze-free downtime. There are plenty of relaxing activities to enjoy — maybe a project (such as putting together a photo collage) that has been on the back burner for a while. Or a feel-good show marathon if you’re not up for getting up from the couch. Creative, comforting activities that feel like a “treat” serve as natural ways to release dopamine, keeping those alcohol cravings at bay.

Once you’re feeling better, you’ll be glad that alcohol didn’t mess with the healing process. Plus, you now have some tools to help you navigate alcohol-related situations well into the post-Mucinex future.

Respecting Your Future Self

In the end, we all get a visit from Mr. Mucus sometimes — it’s part of life. However, adding alcohol to the mix will only make the situation worse. As writer A.J. Jacobs observes in Drop Dead Healthy: One Man's Humble Quest for Bodily Perfection, “The key to making healthy decisions is to respect your future self. Honor him or her. Treat him or her like you would treat a friend or a loved one.” Let’s appreciate the body that does so much for us and give it the love and care it deserves — our future self will thank us!

Mucinex and Alcohol: The Risks

Mucinex used to run commercials featuring “Mr. Mucus,” the lovable green and slimy antihero that the sinus-saving, cold-clearing medicine promises to sweep out of your nasal passages. So when you wake up clogged up and groggy, your eyes stinging and your m’s sounding like b’s when you talk, reaching for that trusty bottle of Mucinex can bring much-needed relief. But then you remember that beer you had before bed. Is it safe to take Mucinex after drinking? Should you wait? Let’s find out more!

What Is Mucinex and What Is It Used For?

As Mr. Mucus shows us, Mucinex is quite the multitasker. The active ingredient, guaifenesin, helps loosen up mucus to flush it out of the body.

A woman sitting on a bed, blowing her nose into a tissue

While it might sound like something that came out of test tubes in the lab, guaifenesin is as natural as it gets. According to The Encyclopedia of Toxicology, it was “originally derived from the guaiac tree and used by Native Americans for health purposes.” Having caught on to its medicinal magic, scientists began to synthesize it in 1912. However, it took 77 years for the FDA to officially approve Mucinex in 1989 and another 15 for Mr. Mucus to officially enter the scene as its mascot in 2004.

From pills to syrups, Mucinex comes in all shapes and sizes. It also “plays well” with other meds and is often combined with antihistamines, cough suppressants, and decongestants.

While Mucinex is a very popular version of guaifenesin (thanks in part to Mr. Mucus and his marketing power), the medication comes under many other brand aliases:

  • Air Power (the dairy-free, vegan version produced by Nature’s Way)
  • Cough Out (just guaifenesin under a different name) 
  • Equaline Tussin and Equate Tussin (also containing dextromethorphan)
  • Good Neighbor Pharmacy Tussin (a “neighborly” mix of dextromethorphan hydrobromide, guaifenesin, and phenylephrine hydrochloride)
  • Good Sense Tussin (guaifenesin with dextromethorphan)
  • Guiatuss (combined with codeine, available by prescription)
  • Leader Adult Tussin (another guaifenesin and dextromethorphan combo) 
  • Leader Mucus Relief (a mix of guaifenesin, hypromellose, magnesium stearate, maltodextrin, microcrystalline cellulose, polyethylene glycol, povidone, silicon dioxide, sodium starch glycolate, stearic acid)
  • Liqufruta (herbal garlic cough syrup with guaifenesin)
  • Refenesen Chest Congestion Relief (also contains phenylephrine)
  • Robitussin Chest Congestion (also contains dextromethorphan)
  • Siltussin (a liquid form of guaifenesin with a twist — this one tastes like strawberries)
  • Wal Tussin (Walgreens’ take on the dextromethorphan-guaifenesin combo)

Many other pharmacies and stores might have their own brand as well; it’s a tried-and-true remedy for congestion!

Can You Drink on Mucinex?

In short, alcohol and Mucinex are not a great mix. To understand why, let’s first take a look at the common side effects Mucinex is known for:

  • Nausea and vomiting. Mucinex can irritate the stomach lining, making us feel queasy or even causing us to throw up. 
  • Drowsiness. Like many other cold medications, Mucinex can make us nod off or feel a bit more drowsy than usual.
  • Headaches. Another pesky side effect some folks experience is headaches. Hint: staying hydrated can help!
  • Dizziness. Mucinex can affect our inner ear, temporarily throwing us off balance. It could also tweak our blood pressure a bit, causing minor fluctuations. Neither of these is a huge deal — it’s a bit like the feeling of standing up too quickly.


None of these are a huge deal on their own, but what happens when we mix them with alcohol? Let’s find out why combining the two is asking for trouble.

Alcohol and Mucinex: Worsened Side Effects 

Now that we have an idea of the side effects of Mucinex, we can see that adding alcohol to the mix isn’t the best idea. When we drink alcohol alongside Mucinex, we run the risk of worsening side effects: 

  • Sedation struggles. Alcohol is a known depressant, which slows down our central nervous system (CNS). And while guaifenesin’s CNS effects with guaifenesin are minimal, the mix could potentially make us extra drowsy and dizzy.
  • Hefty headaches. Both alcohol and Mucinex can cause headaches, so putting the two together is asking for trouble. As if having a cold doesn’t dehydrate us enough, alcohol can cause further dehydration and, consequently, headaches. Alcohol also causes vasodilation, increasing blood flow (and pressure) to the brain. The buildup of acetaldehyde — a toxic byproduct of alcohol metabolism — turns up the headache dial even more.
  • Tummy troubles. We know that Mucinex can be hard on the stomach, and alcohol is even worse. Alcohol amps up stomach acid production, leading to irritation, nausea, and acid reflux. Over time, it could cause problems such as gastritis or stomach ulcers! (For a deeper look, check out our blog: “5 Ways Alcohol Affects the Stomach and Digestive System.”)

All of these symptoms can only make us more miserable when we are sick. But there are even more dangers to drinking alcohol with Mucinex. Let’s take a look. 

Alcohol, Mucinex, and the Liver 

Guaifenesin and alcohol are both metabolized by the liver, which can get overwhelmed by the dual task of digesting both. Even worse, overtasking the liver can lead to a buildup of acetaldehyde, which contributes to hangovers and can even cause serious illnesses in the long run.

Beyond Guaifenesin: Additional Ingredients in Mucinex

Another potential pitfall with combining Mucinex and alcohol? Guaifenesin may not be the only med in the mix. Many formulas that contain it have other ingredients to tackle all those additional cold-related symptoms, such as body aches and pains, cough, headaches, and sinus pain. And once again, most of them are not booze-friendly either: 

  • Dextromethorphan (DXM). According to WebMD, DXM is used to ease cough caused by infections of the air passages triggered by sinusitis or colds. It’s often included in Mucinex as one of the ingredients. 

    The problem with mixing DXM and alcohol? According to Drugs.com, on the lighter side, we could be looking at dizziness, drowsiness, and concentration difficulties. And if things get more serious, there’s a chance of more serious “impairment in thinking and judgment.”
  • Acetaminophen. This one is a bad match for alcohol as well. The liver metabolizes both, so combining the two could lead to toxicity. (For more insight into liver damage from alcohol, take a look at “How Much Alcohol Causes Liver Damage?”).
  • Pseudoephedrine and phenylephrine. These two are great at helping us breathe more easily, but together with alcohol, pseudoephedrine in particular can be bad news. As a central nervous stimulant, it clashes with the depressant effects of booze and strains the heart. Moreover, the dizziness caused by all three — guaifenesin, pseudoephedrine, and alcohol — is a trip-and-fall waiting to happen, especially when we’re already under the weather.

If we’re nursing a cold, it’s better to avoid alcohol altogether. It will not only keep us safe but help us recover faster!

Get Well Later: Alcohol, Mucinex, and the Immune System

Finally, mixing alcohol and Mucinex doesn’t do us any favors when it comes to the reason we’re taking Mucinex in the first place.

For one thing, alcohol can throw a wrench in the workings of our immune system and isn’t the best ally in recovery from illness in general. (For more details, take a look at our blog “Alcohol's Impact on the Immune System.”)

Moreover, alcohol is a notorious diuretic that inhibits the release of the hormone in charge of telling our kidneys to hold onto water. And while Mucinex isn’t dehydrating per se, the cold itself is. So, adding booze to the mix dries up our body — and especially our sensitive nasal passages — even more.

How Many Hours After Taking Mucinex Should I Wait To Drink Alcohol? 

Doctors say to wait at least 12 hours to be safe. But if you have any concerns or are taking additional medications, always check with yours! They know you best and will be able to offer advice that’s tailored to your needs and situation.

How much alcohol is too much? Michigan State professor and physician James J. Galligan said in an interview with Self, “There are many drugs that can interact with alcohol resulting in loss of memory and consciousness … Even one or two drinks can interact with some drugs to produce severe intoxication and potentially loss of consciousness in some people.”

Another physician, David Cutler, clarifies that having a single drink probably won’t be the end of the world. Still, it’s not a great idea: “The problem is that people often think that if they feel OK after having one drink, they can have two, and things go downhill from there. Also, just because you’re probably OK if you stick with one drink doesn’t mean you can’t have a bad reaction. ‘It’s not that you’ll never have one, it’s just unlikely.’”

Tips To Stay Safe and Get Well When Taking Mucinex

Tips To Stay Safe and Get Well

To help you stay safe while taking Mucinex — as well as after you recover — consider these tips:

  1. Watch your intake. If alcohol has become a frequent habit, taking a break might seem a bit tough at first, but look at it as an opportunity to explore a healthier lifestyle! It’s best to avoid mixing alcohol and Mucinex to avoid a potentially dangerous mix of side effects, among other reasons.
  2. Hydrate. Hydration is crucial every day, but it’s especially important when we’re sick. Dehydration can also make Mucinex side effects such as nausea and headaches worse, so drink up!
  3. Nourish your body. Remember how your mom told you to “feed a cold”? Nutritious food is always important, but it’s especially crucial when we’re under the weather. Chicken soup is an old favorite for a reason — the warm brew is soothing for the throat and sinuses, while the chicken provides some much-needed energy. And those vitamin-packed veggies? An added boost for your immune system!
  4. Try some ginger tea. Ginger tea is known for its anti-nausea properties, plus it’s soothing! So if your cold (and Mucinex) are making you queasy, this time-tested cure could work wonders!
  5. Take time to heal. Take this time as an opportunity to enjoy some booze-free downtime. There are plenty of relaxing activities to enjoy — maybe a project (such as putting together a photo collage) that has been on the back burner for a while. Or a feel-good show marathon if you’re not up for getting up from the couch. Creative, comforting activities that feel like a “treat” serve as natural ways to release dopamine, keeping those alcohol cravings at bay.

Once you’re feeling better, you’ll be glad that alcohol didn’t mess with the healing process. Plus, you now have some tools to help you navigate alcohol-related situations well into the post-Mucinex future.

Respecting Your Future Self

In the end, we all get a visit from Mr. Mucus sometimes — it’s part of life. However, adding alcohol to the mix will only make the situation worse. As writer A.J. Jacobs observes in Drop Dead Healthy: One Man's Humble Quest for Bodily Perfection, “The key to making healthy decisions is to respect your future self. Honor him or her. Treat him or her like you would treat a friend or a loved one.” Let’s appreciate the body that does so much for us and give it the love and care it deserves — our future self will thank us!

Alcohol and Medications
2024-04-25 9:00
Alcohol and Medications
Can You Drink Alcohol While Taking Omeprazole?
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Struggling with heartburn? Taking Prilosec? Planning on drinking this weekend? Here’s what you need to know about omeprazole and alcohol.

10 min read

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You just got back from lunch break, and you’ve got that familiar fire in your chest and bitter taste in your mouth. And you don’t dare bend over to pick up that paper you just dropped for fear your lunch will resurface. Ugh — heartburn again. It seems like you can’t eat or drink anything these days without instant regret. 

Your doctor recommended Prilosec, and it’s been helping so far, but you have a wedding to attend this weekend. Can you take omeprazole with alcohol? 

What Is Omeprazole? 

Omeprazole is a medicine —a proton pump inhibitor (PPI) to be precise — used to reduce the amount of acid in the stomach. Often known by the brand name Prilosec, omeprazole is used to treat frequent heartburn or conditions where too much acid is produced in the stomach: 

  • Gastric and duodenal ulcers 
  • Erosive esophagitis
  • Gastroesophageal reflux disease (GERD)
  • Gastroparesis 

In these conditions, there is too much acid in the stomach, and that acid is pushed from the stomach to the esophagus, causing us some unpleasant symptoms.

As a PPI, omeprazole slows gastric acid secretion by inhibiting an enzyme in the final step of the stomach’s acid secretion process. Does this mean that if we take PPIs we won’t have any stomach acid? No, PPIs only inhibit 66-80% of acid output in our stomach. Having less acid in our stomach can help reduce the instances of GERD, help our esophagus heal if we have erosive esophagitis, or rid us of gastric ulcers. 

Side Effects of Omeprazole

Prilosec is available to buy over-the-counter; however, it is not recommended to take it for more than 14 days without consulting a doctor first. While it is generally safe and effective, some people do experience side effects: 


  • Headaches
  • Abdominal pain
  • Diarrhea
  • Nausea and vomiting 

Extreme doses of 2400 mg (120 times higher than the recommended dose) can lead to more troublesome side effects: 

  • Confusion
  • Drowsiness
  • Tachycardia
  • Blurred vision
  • Diaphoresis 

These symptoms are typically short-lived and don’t cause serious harm, but it is always safest to stick to the recommended dose on the box. 

How To Drink Safely While on Omeprazole

Omeprazole and Alcohol Interaction

From a molecular standpoint, Prilosec and alcohol do not specifically interact. However, as we learned above, alcohol can make our stomach produce more acid. If we are taking omeprazole, we are likely trying to reduce the acid in our stomach, so drinking alcohol may counteract the purpose of the medication. Essentially, alcohol can worsen our underlying problem of having too much stomach acid. 

Furthermore, alcohol and omeprazole share side effects that can be heightened if we use them at the same time. For instance, both can cause headaches, dizziness, upset stomach, and nausea. 

So we know there are problematic interactions between Prilosec and alcohol, but the question remains: can we drink alcohol with omeprazole? 

Can You Drink Alcohol While Taking Omeprazole? 

The short answer is yes — there are no immediate dangers to drinking alcohol while taking omeprazole as there would be with sleeping pills. Drinking while on Prilosec doesn’t increase our chances of having severe side effects or an overdose of alcohol. However, most medical professionals suggest not drinking while on omeprazole since it can make our stomach issues worse. In the long run, continuously combining the two can lead to greater challenges:

  • Worsened acid reflux 
  • Increased chances of liver disease, injury, or cancer
  • Magnesium deficiency 

So, if we are on omeprazole and we want to drink, how long should we wait between the two of them? 

There is no straightforward answer, but we are supposed to take omeprazole 30-60 minutes before we eat. Likewise, we should wait at least 30-60 minutes before or after drinking alcohol.

How To Drink Alcohol Safely While on Prilosec

It is not recommended to drink alcohol while on Prilosec, but there is no risk to our immediate health if we do. Still, there are precautions we can take to drink alcohol safely while on omeprazole:

  • Drink in moderation. Whether you’re on omeprazole or not, this is always a good guideline.
  • Avoid spicy foods and carbonated drinks. Both can make our stomach acid worse.
  • Take a break from alcohol. If you are omeprazole for the 14-day, over-the-counter dose, hold off on alcohol while you get your acid production under control. 
  • Choose your booze carefully. Certain types of alcohol are less acidic than others. Generally, the higher the alcohol content, the worse we may react to it. A light beer may be better than a stronger spirit such as whiskey or scotch. Highly acidic drinks like ciders, white wines, and citrus cocktails can be harder on the stomach. 

The bottom line is that drinking alcohol while on omeprazole can make our acid reflux symptoms worse. If you’re experiencing daily discomfort due to heartburn, it is best to avoid alcohol altogether. 

The Bottom Line 

Ultimately, drinking alcohol while on omeprazole is safe but not recommended. There is no immediate risk of developing severe side effects or overdose, but if we are heavy drinkers and on PPIs long term, we are at greater risk for developing liver disease. Consult your prescribing physician before drinking alcohol if you are on Omeprazole for a chronic condition.

You just got back from lunch break, and you’ve got that familiar fire in your chest and bitter taste in your mouth. And you don’t dare bend over to pick up that paper you just dropped for fear your lunch will resurface. Ugh — heartburn again. It seems like you can’t eat or drink anything these days without instant regret. 

Your doctor recommended Prilosec, and it’s been helping so far, but you have a wedding to attend this weekend. Can you take omeprazole with alcohol? 

What Is Omeprazole? 

Omeprazole is a medicine —a proton pump inhibitor (PPI) to be precise — used to reduce the amount of acid in the stomach. Often known by the brand name Prilosec, omeprazole is used to treat frequent heartburn or conditions where too much acid is produced in the stomach: 

  • Gastric and duodenal ulcers 
  • Erosive esophagitis
  • Gastroesophageal reflux disease (GERD)
  • Gastroparesis 

In these conditions, there is too much acid in the stomach, and that acid is pushed from the stomach to the esophagus, causing us some unpleasant symptoms.

As a PPI, omeprazole slows gastric acid secretion by inhibiting an enzyme in the final step of the stomach’s acid secretion process. Does this mean that if we take PPIs we won’t have any stomach acid? No, PPIs only inhibit 66-80% of acid output in our stomach. Having less acid in our stomach can help reduce the instances of GERD, help our esophagus heal if we have erosive esophagitis, or rid us of gastric ulcers. 

Side Effects of Omeprazole

Prilosec is available to buy over-the-counter; however, it is not recommended to take it for more than 14 days without consulting a doctor first. While it is generally safe and effective, some people do experience side effects: 


  • Headaches
  • Abdominal pain
  • Diarrhea
  • Nausea and vomiting 

Extreme doses of 2400 mg (120 times higher than the recommended dose) can lead to more troublesome side effects: 

  • Confusion
  • Drowsiness
  • Tachycardia
  • Blurred vision
  • Diaphoresis 

These symptoms are typically short-lived and don’t cause serious harm, but it is always safest to stick to the recommended dose on the box. 

How To Drink Safely While on Omeprazole

Omeprazole and Alcohol Interaction

From a molecular standpoint, Prilosec and alcohol do not specifically interact. However, as we learned above, alcohol can make our stomach produce more acid. If we are taking omeprazole, we are likely trying to reduce the acid in our stomach, so drinking alcohol may counteract the purpose of the medication. Essentially, alcohol can worsen our underlying problem of having too much stomach acid. 

Furthermore, alcohol and omeprazole share side effects that can be heightened if we use them at the same time. For instance, both can cause headaches, dizziness, upset stomach, and nausea. 

So we know there are problematic interactions between Prilosec and alcohol, but the question remains: can we drink alcohol with omeprazole? 

Can You Drink Alcohol While Taking Omeprazole? 

The short answer is yes — there are no immediate dangers to drinking alcohol while taking omeprazole as there would be with sleeping pills. Drinking while on Prilosec doesn’t increase our chances of having severe side effects or an overdose of alcohol. However, most medical professionals suggest not drinking while on omeprazole since it can make our stomach issues worse. In the long run, continuously combining the two can lead to greater challenges:

  • Worsened acid reflux 
  • Increased chances of liver disease, injury, or cancer
  • Magnesium deficiency 

So, if we are on omeprazole and we want to drink, how long should we wait between the two of them? 

There is no straightforward answer, but we are supposed to take omeprazole 30-60 minutes before we eat. Likewise, we should wait at least 30-60 minutes before or after drinking alcohol.

How To Drink Alcohol Safely While on Prilosec

It is not recommended to drink alcohol while on Prilosec, but there is no risk to our immediate health if we do. Still, there are precautions we can take to drink alcohol safely while on omeprazole:

  • Drink in moderation. Whether you’re on omeprazole or not, this is always a good guideline.
  • Avoid spicy foods and carbonated drinks. Both can make our stomach acid worse.
  • Take a break from alcohol. If you are omeprazole for the 14-day, over-the-counter dose, hold off on alcohol while you get your acid production under control. 
  • Choose your booze carefully. Certain types of alcohol are less acidic than others. Generally, the higher the alcohol content, the worse we may react to it. A light beer may be better than a stronger spirit such as whiskey or scotch. Highly acidic drinks like ciders, white wines, and citrus cocktails can be harder on the stomach. 

The bottom line is that drinking alcohol while on omeprazole can make our acid reflux symptoms worse. If you’re experiencing daily discomfort due to heartburn, it is best to avoid alcohol altogether. 

The Bottom Line 

Ultimately, drinking alcohol while on omeprazole is safe but not recommended. There is no immediate risk of developing severe side effects or overdose, but if we are heavy drinkers and on PPIs long term, we are at greater risk for developing liver disease. Consult your prescribing physician before drinking alcohol if you are on Omeprazole for a chronic condition.

Alcohol and Medications