A team of researchers and psychologists who specialize in behavioral health and neuroscience. This group collaborates to produce insightful and evidence-based content.
Certified recovery coach specialized in helping everyone redefine their relationship with alcohol. His approach in coaching focuses on habit formation and addressing the stress in our lives.
Recognized by Fortune and Fast Company as a top innovator shaping the future of health and known for his pivotal role in helping individuals change their relationship with alcohol.
April 6, 2024
·
14 min read
Reframe Content Team
April 6, 2024
·
14 min read
The Dangerous Mix of Tramadol and Alcohol
Tramadol is an opioid medication that is used to relieve pain. Drinking alcohol while on Tramadol is dangerous because it enhances the effects of each substance and increases the chance an overdose.
Quitting alcohol and Tramadol is best done by addressing both substances at the same time. It is best to detox under the supervision of medical professionals.
Reframe can help you quit or cut back on alcohol! Start now to improve your health by working with peers and coaches.
Pain from a recent surgery or injury can be a burden. For relief, we may be prescribed an opioid such as Tramadol. As we start to recover, we might be tempted to start our normal routines and activities. That Friday night happy hour with coworkers sounds like the perfect way to unwind after a long week! But wait … what about that Tramadol? What happens if we have just one drink? Is it safe?
In this blog, we will learn that it is not safe to drink alcohol while taking Tramadol. Keep reading to learn the science behind the dangers of mixing alcohol and Tramadol. Learn some tips for cutting back on both substances and when it is safe to drink alcohol after we stop taking Tramadol.
What Is Tramadol?
Tramadol is a prescription medication used to relieve moderate to severe pain. It is in the class of medications called opioids, which are derived from or mimic the opium poppy plant. Opioids are prescribed by physicians for pain management but are known for being highly addictive. Tramadol is a synthetic opioid and has a lower level of opioid content than other opioids such as morphine, oxycodone, or fentanyl, so it is thought to have lower addiction potential than others. Taking Tramadol outside of the prescription parameters is illegal and has dangerous consequences!
How Tramadol Works
Tramadol is a depressant drug, meaning it slows down the central nervous system by acting on opioid receptors and neurotransmitters in our brains. Our brains have an endogenous (built-in) opioid-production system that helps us cope with stress and pain while increasing feelings of pleasure, relaxation, and contentment.
Endogenous opioids also control our breathing, coughing, and that warm, relaxed, satisfied feeling following exercise. When we take Tramadol, it partially binds to our opioid receptors, which then release endorphins (euphoria hormones) that reduce the sensation of pain.
Tramadol vs. Other Opioids
Tramadol is not one of the strongest opioids, because it doesn’t bind as strongly to opioid receptors. However, Tramadol affects other neurotransmitters in our brain. Neurotransmitters are chemicals in the brain that are responsible for communication between the cells (neurons).
Tramadol impacts the neurotransmitters norepinephrine and serotonin. Norepinephrine is known as the body's “fight-or-flight” chemical and is responsible for the regulation of arousal, attention, cognitive function, and stress reaction. That rapid increase in heart rate after hearing a loud noise comes from norepinephrine. Serotonin is referred to as the “happy” chemical because it regulates feelings of satisfaction, happiness, and optimism.
Tramadol increases the release of serotonin and blocks the reabsorption of serotonin and norepinephrine to neurons. By blocking reabsorption of excess serotonin and norepinephrine, there are more feel-good chemicals to act on nearby neurons and change our thoughts or behavior and reduce our pain.
Side Effects of Tramadol
Tramadol is effective at reducing moderate to severe pain, but it does come at a cost. Let’s review some common side effects associated with Tramadol.
Dizziness
Headaches
Sleepiness, tired, “spaced out”
Nausea, vomiting, heartburn
Constipation
Dry mouth
Sweating
Low energy
Serious (and less common) side effects include the following:
Extreme dizziness
Hallucinations
Confusion
Extreme fatigue
There is a risk for overdose with Tramadol if we do not follow the medically prescribed doses. If you notice any of the following signs of overdose, immediately seek emergency medical care!
Loss or change of consciousness
Lack of awareness or unresponsive
Difficulty breathing
Lack of muscle tone
Lightheadedness
Pinpointed pupils
Severe sleepiness or drowsiness
Slow or irregular heart rate
Tramadol misuse can be dangerous to our health. If we take Tramadol as prescribed, we might only experience minor side effects. Before we decide to have a drink while we are on Tramadol, let’s figure out how alcohol and Tramadol might interact.
Is It Dangerous To Mix Tramadol and Alcohol?
You should never drink alcohol while on Tramadol or other opioids! It doesn’t matter if it's beer, wine, or your favorite spirit — even a low amount of alcohol can have life-threatening consequences! Let’s go through some of the dangers of having alcohol and Tramadol.
Increased chance of overdose. Tramadol and alcohol slow our brains down, which can impact key functions such as breathing and heart rate. If the effects are severe enough, the combination can result in unconsciousness or death.
Enhanced side effects. Drinking alcohol while on Tramadol can intensify the reaction to both substances. The mix can lead to atypical reactions such as nausea, vomiting, confusion, disorientation, dizziness, blurred vision, increased blood pressure, insomnia, coma, or seizures.
Increased risk of accidents or injury. The intense lack of alertness, coordination, or impaired judgment can lead to risky decision-making that can result in injury to ourselves or others.
Damage to the liver. Alcohol and Tramadol are both metabolized in the liver. Both substances can cause extra strain on the liver and lead to liver-related diseases. When paired, the liver has to work overtime, amplifying the stress.
Drinking alcohol while on Tramadol is not advised! It can lead to severe consequences such as injury or death!
Treating Comorbid Substance Use Disorders
Treatment for polysubstance drug dependence (misusing more than one drug at once) must focus on treating both substances at once to have the best success. It’s not easy quitting multiple substances at once, but thankfully there are ways to make quitting alcohol and Tramadol more manageable.
Detox. The first step to quitting both substances is ridding them from the body through a detoxification process. During this time, the body will go through withdrawal symptoms for both substances. Detoxing at a hospital or medical facility is the safest option due to the risks associated with withdrawal.
Therapy. Talk therapy or counseling can help along the way to sobriety. There are many options for therapy such as cognitive behavioral, art, or psychotherapy. Finding one that is best for you can help with the road to recovery.
Support groups. Support groups can be a great resource — they offer validation and encouragement during the recovery process. A supportive community is a pivotal factor in successful recovery.
Abruptly stopping Tramadol and alcohol can be dangerous! Quitting alcohol cold turkey can result in life-threatening withdrawal symptoms such as seizures or delirium tremens. Seek advice from medical professionals before attempting to quit Tramadol and alcohol use.
Other Medications To Avoid Mixing With Tramadol
There are many other medications that are unsafe to mix with Tramadol. In general, sedatives or medications that slow the brain, medications that raise serotonin levels, or other opioids should be avoided while taking Tramadol. Let’s review some other substances that you should not mix with Tramadol.
Antidepressants (e.g., bupropion (Wellbutrin), fluoxetine (Prozac), or paroxetine (Paxil))
Benzodiazepines (e.g., Xanax, Valium, or Klonopin)
Other opioids (oxycodone, hydrocodone, morphine, codeine)
Always consult your physician and a pharmacist before adding any medications to your regimen.
How To Wait Before Drinking After Tramadol
We learned that drinking alcohol while taking Tramadol can be extremely dangerous, but you may be wondering, “How long after taking Tramadol can I drink alcohol?”
Tramadol has a half-life of six to eight hours. A half-life is the amount of time our bodies take to reduce the amount of drug by one half. It takes the body about four or five half-lives to fully get rid of Tramadol. It’s safest to wait 30-40 hours after our last dose of Tramadol before we start drinking. That’s about a day and a half.
Key Takeaways
Tramadol is an opioid medication used to treat pain. Alcohol and Tramadol are both depressants and when taken together, they can intensify one another’s side effects. We should not drink alcohol while on Tramadol because it can lead to serious side effects and increase our chances of overdose. Trying to quit both substances at once can be dangerous and it’s advised to seek medical attention while detoxing.
Summary FAQs
1. Can I take Tramadol if I've been drinking?
It’s not recommended to take Tramadol if you’ve been drinking because it can increase the risk of overdose or other serious health conditions.
2. How long after Tramadol can I drink?
You should wait 30-40 hours (a day and a half to two days) after your last dose of Tramadol before drinking. Tramadol’s half-life is 4 to 6 hours, but takes about 4 or 5 half-life cycles before it’s fully removed from the body.
3. What medications can I not mix with Tramadol?
Do not mix other opioids, medications that raise serotonin levels, sleep aids, benzodiazepines, or barbiturates.
4. Is Tramadol hard on the liver?
At normal prescription doses, Tramadol alone does not usually cause liver damage. But since alcohol and Tramadol are both metabolized in the liver, mixing them can strain the liver and cause damage.
5. What kinds of alcohol are okay to mix with Tramadol?
You really shouldn’t mix any alcohol with Tramadol — as mentioned, any alcohol is dangerous. Tramadol and wine? Nope! Tramadol and beer? Not today! Stick with water, soda, or juice. If you’re going to an event with alcohol, consider a mocktail!
Drink Less and Thrive With Reframe!
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually, with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet hundreds of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!
Reframe has helped over 2 millions people to build healthier drinking habits globally
At Reframe, we do science, not stigma. We base our articles on the latest peer-reviewed research in psychology, neuroscience, and behavioral science. We follow the Reframe Content Creation Guidelines, to ensure that we share accurate and actionable information with our readers. This aids them in making informed decisions on their wellness journey. Learn more
Updated Regularly
Our articles undergo frequent updates to present the newest scientific research and changes in expert consensus in an easily understandable and implementable manner.